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WIREs Syst Biol Med
Impact Factor: 2.385

Physiology

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Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape

Advanced Review
Gianmarco Rinaldi, Matteo Rossi, Sarah‐Maria Fendt
Published Online: Aug 30 2017
DOI:10.1002/wsbm.1397

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of oxygen homeostasis

Advanced Review
Debangshu Samanta, Nanduri R. Prabhakar, Gregg L. Semenza
Published Online: Feb 21 2017
DOI:10.1002/wsbm.1382

Abstract Full article on Wiley Online Library:   HTML | PDF
Traditional and novel tools to probe the mitochondrial metabolism in health and disease

Advanced Review
Yanfei Zhang, José L. Avalos
Published Online: Jan 09 2017
DOI:10.1002/wsbm.1373

Abstract Full article on Wiley Online Library:   HTML | PDF
Computational models of the neural control of breathing

Advanced Review
Yaroslav I. Molkov, Jonathan E. Rubin, Ilya A. Rybak, Jeffrey C. Smith
Published Online: Dec 23 2016
DOI:10.1002/wsbm.1371

Abstract Full article on Wiley Online Library:   HTML | PDF
Cancer and inflammation

Overview
Lance L. Munn
Published Online: Dec 12 2016
DOI:10.1002/wsbm.1370

Abstract Full article on Wiley Online Library:   HTML | PDF
Mathematical modeling of the female reproductive system: from oocyte to delivery

Overview
Alys R Clark, Jennifer A Kruger
Published Online: Sep 09 2016
DOI:10.1002/wsbm.1353

Abstract Full article on Wiley Online Library:   HTML | PDF
Network dynamics: quantitative analysis of complex behavior in metabolism, organelles, and cells, from experiments to models and back

Advanced Review
Felix T. Kurz, Jackelyn M. Kembro, Ana G. Flesia, Antonis A. Armoundas, Sonia Cortassa, Miguel A. Aon, David Lloyd
Published Online: Sep 07 2016
DOI:10.1002/wsbm.1352

Abstract Full article on Wiley Online Library:   HTML | PDF
In silico bone mechanobiology: modeling a multifaceted biological system

Advanced Review
Mario Giorgi, Stefaan W. Verbruggen, Damien Lacroix
Published Online: Sep 07 2016
DOI:10.1002/wsbm.1356

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems physiology of the airways in health and obstructive pulmonary disease

Advanced Review
Jason H.T. Bates
Published Online: Jun 24 2016
DOI:10.1002/wsbm.1347

Abstract Full article on Wiley Online Library:   HTML | PDF
Mitochondrial metabolic remodeling in response to genetic and environmental perturbations

Advanced Review
Kate E.R. Hollinshead, Daniel A. Tennant
Published Online: May 19 2016
DOI:10.1002/wsbm.1334

Abstract Full article on Wiley Online Library:   HTML | PDF
Adaptive resistance to antibiotics in bacteria: a systems biology perspective

Advanced Review
Santiago Sandoval‐Motta, Maximino Aldana
Published Online: Apr 21 2016
DOI:10.1002/wsbm.1335

Abstract Full article on Wiley Online Library:   HTML | PDF
Signaling via the NFκB system

Advanced Review
Simon Mitchell, Jesse Vargas, Alexander Hoffmann
Published Online: Mar 16 2016
DOI:10.1002/wsbm.1331

Abstract Full article on Wiley Online Library:   HTML | PDF
Dynamics of the mammalian cell cycle in physiological and pathological conditions

Focus Article
Claude Gérard, Albert Goldbeter
Published Online: Nov 27 2015
DOI:10.1002/wsbm.1325

Abstract Full article on Wiley Online Library:   HTML | PDF
The virtual intestine: in silico modeling of small intestinal electrophysiology and motility and the applications

Advanced Review
Peng Du, Niranchan Paskaranandavadivel, Timothy R. Angeli, Leo K. Cheng, Gregory O'Grady
Published Online: Nov 12 2015
DOI:10.1002/wsbm.1324

Abstract Full article on Wiley Online Library:   HTML | PDF
Measurement and modeling of coronary blood flow

Overview
Matthew D. Sinclair, Jack Lee, Andrew N. Cookson, Simone Rivolo, Eoin R. Hyde, Nicolas P. Smith
Published Online: Jun 30 2015
DOI:10.1002/wsbm.1309

Abstract Full article on Wiley Online Library:   HTML | PDF
Implementation of integral feedback control in biological systems

Advanced Review
Pramod R. Somvanshi, Anilkumar K. Patel, Sharad Bhartiya, K. V. Venkatesh
Published Online: Jun 02 2015
DOI:10.1002/wsbm.1307

Abstract Full article on Wiley Online Library:   HTML | PDF
The role of the microbiota in ageing: current state and perspectives

Focus Article
Denise B. Lynch, Ian B. Jeffery, Paul W. O'Toole
Published Online: Mar 16 2015
DOI:10.1002/wsbm.1293

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems engineering meets quantitative systems pharmacology: from low‐level targets to engaging the host defenses

Opinion
Ioannis P. Androulakis
Published Online: Mar 16 2015
DOI:10.1002/wsbm.1294

Abstract Full article on Wiley Online Library:   HTML | PDF
Experience‐sensitive epigenetic mechanisms, developmental plasticity, and the biological embedding of chronic disease risk

Overview
Vincent T. Cunliffe
Published Online: Feb 20 2015
DOI:10.1002/wsbm.1291

Abstract Full article on Wiley Online Library:   HTML | PDF
Tactile sensory system: encoding from the periphery to the cortex

Focus Article
Lynette A. Jones, Allan M. Smith
Published Online: Mar 19 2014
DOI:10.1002/wsbm.1267

Abstract Full article on Wiley Online Library:   HTML | PDF
Apolipoprotein E receptor pathways in Alzheimer disease

Advanced Review
Vanessa Schmidt, Anne‐Sophie Carlo, Thomas E. Willnow
Published Online: Mar 06 2014
DOI:10.1002/wsbm.1262

Abstract Full article on Wiley Online Library:   HTML | PDF
Axes of differentiation in breast cancer: untangling stemness, lineage identity, and the epithelial to mesenchymal transition

Advanced Review
Roy Z. Granit, Michal Slyper, Ittai Ben‐Porath
Published Online: Nov 08 2013
DOI:10.1002/wsbm.1252

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrative approaches for modeling regulation and function of the respiratory system

Overview
Alona Ben‐Tal, Merryn H. Tawhai
Published Online: Sep 09 2013
DOI:10.1002/wsbm.1244

Abstract Full article on Wiley Online Library:   HTML | PDF
Mathematical modeling of kidney transport

Advanced Review
Anita T. Layton
Published Online: Jul 12 2013
DOI:10.1002/wsbm.1232

Abstract Full article on Wiley Online Library:   HTML | PDF
Fatty acid oxidation: systems analysis and applications

Focus Article
Angela Cintolesi, María Rodríguez‐Moyá, Ramon Gonzalez
Published Online: May 09 2013
DOI:10.1002/wsbm.1226

Abstract Full article on Wiley Online Library:   HTML | PDF
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In the Spotlight

Jens Nielsen

Jens Nielsen
is a Professor in the Department of Biology and Biological Engineering at Chalmers University of Technology in Göteborg, Sweden. His research focus is on systems biology of metabolism. The yeast Saccharomyces cerevisiae is the lab’s key organism for experimental research, but they also work with Aspergilli oryzae.

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