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WIREs Syst Biol Med
Impact Factor: 3.542

Biological Mechanisms

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Growth control in the Drosophila wing disk

Advanced Review
Hans G. Othmer, Jay A. Stotsky, Jia Gou
Published Online: Jan 09 2020
DOI:10.1002/wsbm.1478

Abstract Full article on Wiley Online Library:   HTML | PDF
Single‐cell analysis of CD8 T lymphocyte diversity during adaptive immunity

Focus Article
Janilyn Arsenio
Published Online: Dec 26 2019
DOI:10.1002/wsbm.1475

Abstract Full article on Wiley Online Library:   HTML | PDF
Lactate: Fueling the fire starter

Advanced Review
Valentina Pucino, Claudio Mauro, Amato Paulis, Giancarlo Marone, Michelangelo Certo
Published Online: Dec 16 2019
DOI:10.1002/wsbm.1474

Abstract Full article on Wiley Online Library:   HTML | PDF
Theory of cell fate

Primer
Ben D. MacArthur, Patrick S. Stumpf, Michael J. Casey
Published Online: Dec 12 2019
DOI:10.1002/wsbm.1471

Abstract Full article on Wiley Online Library:   HTML | PDF
Applications of stable isotope‐based metabolomics and fluxomics toward synthetic biology of cyanobacteria

Advanced Review
Jamey D. Young, Piyoosh Kumar Babele
Published Online: Dec 09 2019
DOI:10.1002/wsbm.1472

Abstract Full article on Wiley Online Library:   HTML | PDF
Network architecture and regulatory logic in neural crest development

Focus Article
Marcos Simoes‐Costa, Megan Rothstein, Austin S. Hovland
Published Online: Nov 08 2019
DOI:10.1002/wsbm.1468

Abstract Full article on Wiley Online Library:   HTML | PDF
Going low to reach high: Small‐scale ChIP‐seq maps new terrain

Advanced Review
Madeleine Fosslie, Adeel Manaf, Mads Lerdrup, Klaus Hansen, Gregor D. Gilfillan, John Arne Dahl
Published Online: Sep 03 2019
DOI:10.1002/wsbm.1465

Abstract Full article on Wiley Online Library:   HTML | PDF
Decoding pluripotency: Genetic screens to interrogate the acquisition, maintenance, and exit of pluripotency

Overview
Qing V. Li, Bess P. Rosen, Danwei Huangfu
Published Online: Aug 13 2019
DOI:10.1002/wsbm.1464

Abstract Full article on Wiley Online Library:   HTML | PDF
Neutrophils in innate immunity and systems biology‐level approaches

UPDATE
Viktoria Rungelrath, Scott D. Kobayashi, Frank R. DeLeo
Published Online: Jun 20 2019
DOI:10.1002/wsbm.1458

Abstract Full article on Wiley Online Library:   HTML | PDF
IL7 receptor signaling in T cells: A mathematical modeling perspective

Overview
Jung‐Hyun Park, Adam T. Waickman, Joseph Reynolds, Mario Castro, Carmen Molina‐París
Published Online: May 28 2019
DOI:10.1002/wsbm.1447

Abstract Full article on Wiley Online Library:   HTML | PDF
Circadian rhythms and proteomics: It's all about posttranslational modifications!

Focus Article
Daniel Mauvoisin
Published Online: Apr 29 2019
DOI:10.1002/wsbm.1450

Abstract Full article on Wiley Online Library:   HTML | PDF
Essential contributions of enhancer genomic regulatory elements to microglial cell identity and functions

Focus Article
André Machado Xavier, Sarah Belhocine, David Gosselin
Published Online: Apr 23 2019
DOI:10.1002/wsbm.1449

Abstract Full article on Wiley Online Library:   HTML | PDF
Calcium signals that determine vascular resistance

Focus Article
Matteo Ottolini, Kwangseok Hong, Swapnil K. Sonkusare
Published Online: Mar 18 2019
DOI:10.1002/wsbm.1448

Abstract Full article on Wiley Online Library:   HTML | PDF
Towards multiscale modeling of the CD8+ T cell response to viral infections

Advanced Review
Subhasish Baral, Rubesh Raja, Pramita Sen, Narendra M. Dixit
Published Online: Feb 27 2019
DOI:10.1002/wsbm.1446

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrating molecular networks with genetic variant interpretation for precision medicine

Overview
Hannah Carter, Kivilcim Ozturk, Emidio Capriotti
Published Online: Dec 12 2018
DOI:10.1002/wsbm.1443

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of robustness and homeostatic mechanisms

Overview
H. Frederik Nijhout, Janet A. Best, Michael C. Reed
Published Online: Oct 29 2018
DOI:10.1002/wsbm.1440

Abstract Full article on Wiley Online Library:   HTML | PDF
Context‐dependent regulation of receptor tyrosine kinases: Insights from systems biology approaches

Focus Article
Inez Lam, Christina M. Pickering, Feilim Mac Gabhann
Published Online: Sep 26 2018
DOI:10.1002/wsbm.1437

Abstract Full article on Wiley Online Library:   HTML | PDF
Committing the primordial germ cell: An updated molecular perspective

Advanced Review
Haihan Tan, Wee‐Wei Tee
Published Online: Sep 17 2018
DOI:10.1002/wsbm.1436

Abstract Full article on Wiley Online Library:   HTML | PDF
The mechanistic basis for chromatin regulation by pioneer transcription factors

Advanced Review
Makiko Iwafuchi‐Doi
Published Online: Jun 27 2018
DOI:10.1002/wsbm.1427

Abstract Full article on Wiley Online Library:   HTML | PDF
Cell cycle regulation of folate‐mediated one‐carbon metabolism

Advanced Review
Xu Lan, Martha S. Field, Patrick J. Stover
Published Online: Jun 11 2018
DOI:10.1002/wsbm.1426

Abstract Full article on Wiley Online Library:   HTML | PDF
Diversification of transcription factor–DNA interactions and the evolution of gene regulatory networks

Advanced Review
Julia M. Rogers, Martha L. Bulyk
Published Online: Apr 25 2018
DOI:10.1002/wsbm.1423

Abstract Full article on Wiley Online Library:   HTML | PDF
Mechanisms of Wnt signaling and control

Overview
Stephanie Grainger, Karl Willert
Published Online: Mar 30 2018
DOI:10.1002/wsbm.1422

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale systems biology of trauma‐induced coagulopathy

Focus Article
Scott L. Diamond, Talid Sinno, Carrie Sims, Evan Tsiklidis
Published Online: Feb 27 2018
DOI:10.1002/wsbm.1418

Abstract Full article on Wiley Online Library:   HTML | PDF
Chromatin modifications in metabolic disease: Potential mediators of long‐term disease risk

Focus Article
Dustin E. Schones, Kevin R. Costello
Published Online: Jan 25 2018
DOI:10.1002/wsbm.1416

Abstract Full article on Wiley Online Library:   HTML | PDF
Genome‐scale metabolic models applied to human health and disease

Advanced Review
Jens Nielsen, Daniel J Cook
Published Online: Jun 23 2017
DOI:10.1002/wsbm.1393

Abstract Full article on Wiley Online Library:   HTML | PDF
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