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WIREs Syst Biol Med
Impact Factor: 3.542

Models of Systems Properties and Processes

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Regulating cellular cyclic adenosine monophosphate: “Sources,” “sinks,” and now, “tunable valves”

Focus Article
Michael Getz, Padmini Rangamani, Pradipta Ghosh
Published Online: Apr 23 2020
DOI:10.1002/wsbm.1490

Abstract Full article on Wiley Online Library:   HTML | PDF
Molecular networks in Network Medicine: Development and applications

Advanced Review
Jan Baumbach, Kimberly Glass, Gemma Vilahur, Davide Viggiano, Paolo Tieri, John Quackenbush, Manuela Petti, Paola Paci, Claudio Napoli, Cinzia Marchese, Joseph Loscalzo, Michele Gentili, Laurent Gatto, Giulia Fiscon, Lorenzo Farina, Antonella Di Costanzo, Federica Conte, Giovambattista Capasso, Giuditta Benincasa, Jean‐Luc Balligand, Lina Badimon, Marco Angelini, Lucia Altucci, Eleni Anastasiadou, Harald H. H. W. Schmidt, Edwin K. Silverman
Published Online: Apr 20 2020
DOI:10.1002/wsbm.1489

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale modeling of vertebrate limb development

Advanced Review
Tilmann Glimm, Ramray Bhat, Stuart A. Newman
Published Online: Mar 25 2020
DOI:10.1002/wsbm.1485

Abstract Full article on Wiley Online Library:   HTML | PDF
Aspirin and the chemoprevention of cancers: A mathematical and evolutionary dynamics perspective

Advanced Review
Dominik Wodarz, Ajay Goel, C. Richard Boland, Natalia L. Komarova
Published Online: Mar 12 2020
DOI:10.1002/wsbm.1487

Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling immune cell behavior across scales in cancer

Advanced Review
Stacey D. Finley, Colin G. Cess, Sahak Z. Makaryan
Published Online: Mar 04 2020
DOI:10.1002/wsbm.1484

Abstract Full article on Wiley Online Library:   HTML | PDF
Calibration of ionic and cellular cardiac electrophysiology models

Advanced Review
Gary R. Mirams, David J. Christini, Chon Lok Lei, Michael Clerx, Dominic G. Whittaker
Published Online: Feb 21 2020
DOI:10.1002/wsbm.1482

Abstract Full article on Wiley Online Library:   HTML | PDF
Intracellular signaling dynamics and their role in coordinating tissue repair

Focus Article
Samuel J. Ghilardi, Breanna M. O'Reilly, Allyson E. Sgro
Published Online: Feb 08 2020
DOI:10.1002/wsbm.1479

Abstract Full article on Wiley Online Library:   HTML | PDF
Cholesterol interaction motifs in G protein‐coupled receptors: Slippery hot spots?

Advanced Review
Amitabha Chattopadhyay, Parijat Sarkar
Published Online: Feb 07 2020
DOI:10.1002/wsbm.1481

Abstract Full article on Wiley Online Library:   HTML | PDF
How personalized heart modeling can help treatment of lethal arrhythmias: A focus on ventricular tachycardia ablation strategies in post‐infarction patients

Advanced Review
Natalia A. Trayanova, Ashish N. Doshi, Adityo Prakosa
Published Online: Jan 09 2020
DOI:10.1002/wsbm.1477

Abstract Full article on Wiley Online Library:   HTML | PDF
Growth control in the Drosophila wing disk

Advanced Review
Jia Gou, Jay A. Stotsky, Hans G. Othmer
Published Online: Jan 09 2020
DOI:10.1002/wsbm.1478

Abstract Full article on Wiley Online Library:   HTML | PDF
Theory of cell fate

Primer
Michael J. Casey, Patrick S. Stumpf, Ben D. MacArthur
Published Online: Dec 12 2019
DOI:10.1002/wsbm.1471

Abstract Full article on Wiley Online Library:   HTML | PDF
Exploring cardiac form and function: A length‐scale computational biology approach

Advanced Review
William F. Sherman, Anna Grosberg
Published Online: Dec 02 2019
DOI:10.1002/wsbm.1470

Abstract Full article on Wiley Online Library:   HTML | PDF
Network architecture and regulatory logic in neural crest development

Focus Article
Marcos Simoes‐Costa, Megan Rothstein, Austin S. Hovland
Published Online: Nov 08 2019
DOI:10.1002/wsbm.1468

Abstract Full article on Wiley Online Library:   HTML | PDF
Skeletal muscle: A review of molecular structure and function, in health and disease

Advanced Review
Kavitha Mukund, Shankar Subramaniam
Published Online: Aug 13 2019
DOI:10.1002/wsbm.1462

Abstract Full article on Wiley Online Library:   HTML | PDF
Hybrid modeling frameworks of tumor development and treatment

UPDATE
Ibrahim M. Chamseddine, Katarzyna A. Rejniak
Published Online: Jul 17 2019
DOI:10.1002/wsbm.1461

Abstract Full article on Wiley Online Library:   HTML | PDF
Stochastic simulation algorithms for computational systems biology: Exact, approximate, and hybrid methods

Advanced Review
Luca Marchetti, Corrado Priami, Federico Reali, Giulia Simoni
Published Online: Jul 01 2019
DOI:10.1002/wsbm.1459

Abstract Full article on Wiley Online Library:   HTML | PDF
Agent‐based models of inflammation in translational systems biology: A decade later

UPDATE
Yoram Vodovotz, Gary An
Published Online: Jul 01 2019
DOI:10.1002/wsbm.1460

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale modeling of the neuromuscular system: Coupling neurophysiology and skeletal muscle mechanics

Advanced Review
Thomas Heidlauf, Francesco Negro, Thomas Klotz, Utku Ş. Yavuz, Oliver Röhrle
Published Online: Jun 24 2019
DOI:10.1002/wsbm.1457

Abstract Full article on Wiley Online Library:   HTML | PDF
IL7 receptor signaling in T cells: A mathematical modeling perspective

Overview
Jung‐Hyun Park, Adam T. Waickman, Joseph Reynolds, Mario Castro, Carmen Molina‐París
Published Online: May 28 2019
DOI:10.1002/wsbm.1447

Abstract Full article on Wiley Online Library:   HTML | PDF
Essential contributions of enhancer genomic regulatory elements to microglial cell identity and functions

Focus Article
André Machado Xavier, Sarah Belhocine, David Gosselin
Published Online: Apr 23 2019
DOI:10.1002/wsbm.1449

Abstract Full article on Wiley Online Library:   HTML | PDF
Calcium signals that determine vascular resistance

Focus Article
Matteo Ottolini, Kwangseok Hong, Swapnil K. Sonkusare
Published Online: Mar 18 2019
DOI:10.1002/wsbm.1448

Abstract Full article on Wiley Online Library:   HTML | PDF
Towards multiscale modeling of the CD8+ T cell response to viral infections

Advanced Review
Subhasish Baral, Rubesh Raja, Pramita Sen, Narendra M. Dixit
Published Online: Feb 27 2019
DOI:10.1002/wsbm.1446

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrating molecular networks with genetic variant interpretation for precision medicine

Overview
Emidio Capriotti, Kivilcim Ozturk, Hannah Carter
Published Online: Dec 12 2018
DOI:10.1002/wsbm.1443

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of robustness and homeostatic mechanisms

Overview
H. Frederik Nijhout, Janet A. Best, Michael C. Reed
Published Online: Oct 29 2018
DOI:10.1002/wsbm.1440

Abstract Full article on Wiley Online Library:   HTML | PDF
Mathematical modeling of circadian rhythms

Focus Article
Ameneh Asgari‐Targhi, Elizabeth B. Klerman
Published Online: Oct 17 2018
DOI:10.1002/wsbm.1439

Abstract Full article on Wiley Online Library:   HTML | PDF
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