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WIREs Syst Biol Med
Impact Factor: 2.385

Laboratory Methods and Technologies

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Immunity to CRISPR Cas9 and Cas12a therapeutics

Focus Article
Wei Leong Chew
Published Online: Oct 30 2017
DOI:10.1002/wsbm.1408

Abstract Full article on Wiley Online Library:   HTML | PDF
Targeting epidermal growth factor receptor co‐dependent signaling pathways in glioblastoma

Opinion
Feng Liu, Paul S. Mischel
Published Online: Sep 11 2017
DOI:10.1002/wsbm.1398

Abstract Full article on Wiley Online Library:   HTML | PDF
Crosstalk between transcription and metabolism: how much enzyme is enough for a cell?

Focus Article
Stefano Donati, Timur Sander, Hannes Link
Published Online: Aug 15 2017
DOI:10.1002/wsbm.1396

Abstract Full article on Wiley Online Library:   HTML | PDF
Dynamic enhancer function in the chromatin context

Focus Article
Ido Goldstein, Gordon L. Hager
Published Online: May 22 2017
DOI:10.1002/wsbm.1390

Abstract Full article on Wiley Online Library:   HTML | PDF
Genome organization during the cell cycle: unity in division

Focus Article
Rosela Golloshi, Jacob T. Sanders, Rachel Patton McCord
Published Online: May 16 2017
DOI:10.1002/wsbm.1389

Abstract Full article on Wiley Online Library:   HTML | PDF
Imaging mass spectrometry for metabolites: technical progress, multimodal imaging, and biological interactions

Advanced Review
Ying‐Ning Ho, Lin‐Jie Shu, Yu‐Liang Yang
Published Online: May 10 2017
DOI:10.1002/wsbm.1387

Abstract Full article on Wiley Online Library:   HTML | PDF
Therapeutic genome engineering via CRISPR ‐Cas systems

Advanced Review
Ana M. Moreno, Prashant Mali
Published Online: Feb 15 2017
DOI:10.1002/wsbm.1380

Abstract Full article on Wiley Online Library:   HTML | PDF
Regulatory elements in molecular networks

Advanced Review
Ashley S. Doane, Olivier Elemento
Published Online: Jan 17 2017
DOI:10.1002/wsbm.1374

Abstract Full article on Wiley Online Library:   HTML | PDF
Insights into nuclear dynamics using live‐cell imaging approaches

Advanced Review
Rachel B. Bigley, Alexander Y. Payumo, Jeffrey M. Alexander, Guo N. Huang
Published Online: Jan 12 2017
DOI:10.1002/wsbm.1372

Abstract Full article on Wiley Online Library:   HTML | PDF
Quantitative approaches for investigating the spatial context of gene expression

Focus Article
Je H. Lee
Published Online: Dec 21 2016
DOI:10.1002/wsbm.1369

Abstract Full article on Wiley Online Library:   HTML | PDF
Network dynamics: quantitative analysis of complex behavior in metabolism, organelles, and cells, from experiments to models and back

Advanced Review
Felix T. Kurz, Jackelyn M. Kembro, Ana G. Flesia, Antonis A. Armoundas, Sonia Cortassa, Miguel A. Aon, David Lloyd
Published Online: Sep 07 2016
DOI:10.1002/wsbm.1352

Abstract Full article on Wiley Online Library:   HTML | PDF
Data sources for in vivo molecular profiling of human phenotypes

Advanced Review
Timothy Cardozo, Priyanka Gupta, Eric Ni, Lauren M. Young, Doreen Tivon, Klara Felsovalyi
Published Online: Sep 07 2016
DOI:10.1002/wsbm.1354

Abstract Full article on Wiley Online Library:   HTML | PDF
CRISPR /Cas9 genome editing throws descriptive 3‐D genome folding studies for a loop

Advanced Review
Jonathan A. Beagan, Jennifer E. Phillips‐Cremins
Published Online: Jun 06 2016
DOI:10.1002/wsbm.1338

Abstract Full article on Wiley Online Library:   HTML | PDF
Accelerated genome engineering through multiplexing

Advanced Review
Zehua Bao, Ryan E. Cobb, Huimin Zhao
Published Online: Sep 22 2015
DOI:10.1002/wsbm.1319

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems approaches to design of targeted therapeutic delivery

Overview
Jacob W. Myerson, Jacob S. Brenner, Colin F. Greineder, Vladimir R. Muzykantov
Published Online: May 06 2015
DOI:10.1002/wsbm.1304

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of host–microbe metabolomics

Advanced Review
Almut Heinken, Ines Thiele
Published Online: Apr 30 2015
DOI:10.1002/wsbm.1301

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems medicine: evolution of systems biology from bench to bedside

Overview
Rui‐Sheng Wang, Bradley A. Maron, Joseph Loscalzo
Published Online: Apr 17 2015
DOI:10.1002/wsbm.1297

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of polycystic kidney disease: a critical review

Focus Article
Luis Fernando Menezes, Gregory G. Germino
Published Online: Feb 02 2015
DOI:10.1002/wsbm.1289

Abstract Full article on Wiley Online Library:   HTML | PDF
Network representations of immune system complexity

Overview
Naeha Subramanian, Parizad Torabi‐Parizi, Rachel A. Gottschalk, Ronald N. Germain, Bhaskar Dutta
Published Online: Jan 27 2015
DOI:10.1002/wsbm.1288

Abstract Full article on Wiley Online Library:   HTML | PDF
Comparative epigenomics: defining and utilizing epigenomic variations across species, time‐course, and individuals

Opinion
Shu Xiao, Xiaoyi Cao, Sheng Zhong
Published Online: Jul 15 2014
DOI:10.1002/wsbm.1274

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrating omics into the cardiac differentiation of human pluripotent stem cells

Focus Article
Agustin Rojas‐Muñoz, Mano R. Maurya, Frederick Lo, Erik Willems
Published Online: Apr 21 2014
DOI:10.1002/wsbm.1268

Abstract Full article on Wiley Online Library:   HTML | PDF
Subdiffractive microscopy: techniques, applications, and challenges

Advanced Review
Brian R. Long, Danielle C. Robinson, Haining Zhong
Published Online: Jan 17 2014
DOI:10.1002/wsbm.1259

Abstract Full article on Wiley Online Library:   HTML | PDF
Genome network medicine: innovation to overcome huge challenges in cancer therapy

Focus Article
Dimitrios H. Roukos
Published Online: Dec 06 2013
DOI:10.1002/wsbm.1254

Abstract Full article on Wiley Online Library:   HTML | PDF
Using systems biology approaches to understand cardiac inflammation and extracellular matrix remodeling in the setting of myocardial infarction

Advanced Review
Omid Ghasemi, Yonggang Ma, Merry L. Lindsey, Yu‐Fang Jin
Published Online: Nov 08 2013
DOI:10.1002/wsbm.1248

Abstract Full article on Wiley Online Library:   HTML | PDF
miRNA regulation in the context of functional protein networks: principles and applications

Focus Article
Mohammed Alshalalfa
Published Online: Nov 08 2013
DOI:10.1002/wsbm.1251

Abstract Full article on Wiley Online Library:   HTML | PDF
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In the Spotlight

Jens Nielsen

Jens Nielsen
is a Professor in the Department of Biology and Biological Engineering at Chalmers University of Technology in Göteborg, Sweden. His research focus is on systems biology of metabolism. The yeast Saccharomyces cerevisiae is the lab’s key organism for experimental research, but they also work with Aspergilli oryzae.

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