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WIREs Syst Biol Med
Impact Factor: 2.385

Translational, Genomic, and Systems Medicine

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Immunity to CRISPR Cas9 and Cas12a therapeutics

Focus Article
Wei Leong Chew
Published Online: Oct 30 2017
DOI:10.1002/wsbm.1408

Abstract Full article on Wiley Online Library:   HTML | PDF
Small molecule signaling, regulation, and potential applications in cellular therapeutics

Advanced Review
Monica P. McNerney, Mark P. Styczynski
Published Online: Sep 28 2017
DOI:10.1002/wsbm.1405

Abstract Full article on Wiley Online Library:   HTML | PDF
Targeting epidermal growth factor receptor co‐dependent signaling pathways in glioblastoma

Opinion
Feng Liu, Paul S. Mischel
Published Online: Sep 11 2017
DOI:10.1002/wsbm.1398

Abstract Full article on Wiley Online Library:   HTML | PDF
Biomechanics of the human uterus

Focus Article
Kristin M. Myers, David Elad
Published Online: May 12 2017
DOI:10.1002/wsbm.1388

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrated precision medicine: the role of electronic health records in delivering personalized treatment

Focus Article
Amy Sitapati, Hyeoneui Kim, Barbara Berkovich, Rebecca Marmor, Siddharth Singh, Robert El‐Kareh, Brian Clay, Lucila Ohno‐Machado
Published Online: Feb 16 2017
DOI:10.1002/wsbm.1378

Abstract Full article on Wiley Online Library:   HTML | PDF
Therapeutic genome engineering via CRISPR ‐Cas systems

Advanced Review
Ana M. Moreno, Prashant Mali
Published Online: Feb 15 2017
DOI:10.1002/wsbm.1380

Abstract Full article on Wiley Online Library:   HTML | PDF
Modified mRNA as a therapeutic tool to induce cardiac regeneration in ischemic heart disease

Focus Article
Yoav Hadas, Michael G. Katz, Charles R. Bridges, Lior Zangi
Published Online: Dec 02 2016
DOI:10.1002/wsbm.1367

Abstract Full article on Wiley Online Library:   HTML | PDF
Computational approaches for the identification of cancer genes and pathways

Advanced Review
Christos M. Dimitrakopoulos, Niko Beerenwinkel
Published Online: Nov 11 2016
DOI:10.1002/wsbm.1364

Abstract Full article on Wiley Online Library:   HTML | PDF
Blood type biochemistry and human disease

Focus Article
D. Rose Ewald, Susan C.J. Sumner
Published Online: Sep 07 2016
DOI:10.1002/wsbm.1355

Abstract Full article on Wiley Online Library:   HTML | PDF
Omics‐based approaches to understand mechanosensitive endothelial biology and atherosclerosis

Advanced Review
Rachel D. Simmons, Sandeep Kumar, Salim Raid Thabet, Sanjoli Sur, Hanjoong Jo
Published Online: Jun 24 2016
DOI:10.1002/wsbm.1344

Abstract Full article on Wiley Online Library:   HTML | PDF
Engineering of synthetic gene circuits for (re‐)balancing physiological processes in chronic diseases

Advanced Review
Lina Schukur, Martin Fussenegger
Published Online: Jun 24 2016
DOI:10.1002/wsbm.1345

Abstract Full article on Wiley Online Library:   HTML | PDF
Mathematical models of breast and ovarian cancers

Advanced Review
Dana‐Adriana Botesteanu, Stanley Lipkowitz, Jung‐Min Lee, Doron Levy
Published Online: Jun 03 2016
DOI:10.1002/wsbm.1343

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems medicine in colorectal cancer: from a mathematical model toward a new type of clinical trial

Advanced Review
Nicoletta Castagnino, Massimo Maffei, Lorenzo Tortolina, Gabriele Zoppoli, Daniela Piras, Alessio Nencioni, Eva Moran, Alberto Ballestrero, Franco Patrone, Silvio Parodi
Published Online: May 30 2016
DOI:10.1002/wsbm.1342

Abstract Full article on Wiley Online Library:   HTML | PDF
In silico methods for drug repurposing and pharmacology

Overview
Rachel A. Hodos, Brian A. Kidd, Khader Shameer, Ben P. Readhead, Joel T. Dudley
Published Online: Apr 15 2016
DOI:10.1002/wsbm.1337

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology approaches for identifying adverse drug reactions and elucidating their underlying biological mechanisms

Advanced Review
Mary Regina Boland, Alexandra Jacunski, Tal Lorberbaum, Joseph D. Romano, Robert Moskovitch, Nicholas P. Tatonetti
Published Online: Nov 12 2015
DOI:10.1002/wsbm.1323

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrative biomarker discovery in neurodegenerative diseases

Overview
André V. Carreiro, Alexandre Mendonça, Mamede de Carvalho, Sara C. Madeira
Published Online: Jul 02 2015
DOI:10.1002/wsbm.1310

Abstract Full article on Wiley Online Library:   HTML | PDF
Genome‐wide association studies in biliary atresia

Advanced Review
Mylarappa Ningappa, Jun Min, Brandon W. Higgs, Chethan Ashokkumar, Sarangarajan Ranganathan, Rakesh Sindhi
Published Online: May 11 2015
DOI:10.1002/wsbm.1303

Abstract Full article on Wiley Online Library:   HTML | PDF
Parsing interindividual drug variability: an emerging role for systems pharmacology

Advanced Review
Richard M. Turner, B. Kevin Park, Munir Pirmohamed
Published Online: May 07 2015
DOI:10.1002/wsbm.1302

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems approaches to design of targeted therapeutic delivery

Overview
Jacob W. Myerson, Jacob S. Brenner, Colin F. Greineder, Vladimir R. Muzykantov
Published Online: May 06 2015
DOI:10.1002/wsbm.1304

Abstract Full article on Wiley Online Library:   HTML | PDF
Network pharmacodynamic models for customized cancer therapy

Focus Article
James M. Gallo, Marc R. Birtwistle
Published Online: Apr 24 2015
DOI:10.1002/wsbm.1300

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems medicine: evolution of systems biology from bench to bedside

Overview
Rui‐Sheng Wang, Bradley A. Maron, Joseph Loscalzo
Published Online: Apr 17 2015
DOI:10.1002/wsbm.1297

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems engineering meets quantitative systems pharmacology: from low‐level targets to engaging the host defenses

Opinion
Ioannis P. Androulakis
Published Online: Mar 16 2015
DOI:10.1002/wsbm.1294

Abstract Full article on Wiley Online Library:   HTML | PDF
A practical model for economic evaluation of tissue‐engineered therapies

Focus Article
Tien‐En Tan, Gary S. L. Peh, Eric A. Finkelstein, Jodhbir S. Mehta
Published Online: Feb 17 2015
DOI:10.1002/wsbm.1292

Abstract Full article on Wiley Online Library:   HTML | PDF
Exploring hypertension genome‐wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics

Advanced Review
Claudia P Cabrera, Fu Liang Ng, Helen R Warren, Michael R Barnes, Patricia B Munroe, Mark J Caulfield
Published Online: Feb 06 2015
DOI:10.1002/wsbm.1290

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of polycystic kidney disease: a critical review

Focus Article
Luis Fernando Menezes, Gregory G. Germino
Published Online: Feb 02 2015
DOI:10.1002/wsbm.1289

Abstract Full article on Wiley Online Library:   HTML | PDF
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In the Spotlight

Jens Nielsen

Jens Nielsen
is a Professor in the Department of Biology and Biological Engineering at Chalmers University of Technology in Göteborg, Sweden. His research focus is on systems biology of metabolism. The yeast Saccharomyces cerevisiae is the lab’s key organism for experimental research, but they also work with Aspergilli oryzae.

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