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WIREs Syst Biol Med
Impact Factor: 3.676

Cellular Models

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Modeling the intracellular organization of calcium signaling

Advanced Review
Geneviève Dupont
Published Online: Mar 06 2014
DOI:10.1002/wsbm.1261

Abstract Full article on Wiley Online Library:   HTML | PDF
Apolipoprotein E receptor pathways in Alzheimer disease

Advanced Review
Vanessa Schmidt, Anne‐Sophie Carlo, Thomas E. Willnow
Published Online: Mar 06 2014
DOI:10.1002/wsbm.1262

Abstract Full article on Wiley Online Library:   HTML | PDF
Endothelial cell motility, coordination and pattern formation during vasculogenesis

Advanced Review
Andras Czirok
Published Online: Jul 15 2013
DOI:10.1002/wsbm.1233

Abstract Full article on Wiley Online Library:   HTML | PDF
Excitable behavior in amoeboid chemotaxis

Focus Article
Changji Shi, Pablo A. Iglesias
Published Online: Jun 11 2013
DOI:10.1002/wsbm.1230

Abstract Full article on Wiley Online Library:   HTML | PDF
Toward the virtual stomach: progress in multiscale modeling of gastric electrophysiology and motility

Focus Article
Peng Du, Gregory O'Grady, Jerry Gao, Shameer Sathar, Leo K. Cheng
Published Online: Mar 05 2013
DOI:10.1002/wsbm.1218

Abstract Full article on Wiley Online Library:   HTML | PDF
Hierarchical approaches for systems modeling in cardiac development

Overview
Russell A. Gould, Lina M. Aboulmouna, Jeffrey D. Varner, Jonathan T. Butcher
Published Online: Mar 05 2013
DOI:10.1002/wsbm.1217

Abstract Full article on Wiley Online Library:   HTML | PDF
Engineered genetic information processing circuits

Overview
Hao Qi, Andrew Blanchard, Ting Lu
Published Online: Feb 26 2013
DOI:10.1002/wsbm.1216

Abstract Full article on Wiley Online Library:   HTML | PDF
Mechano‐sensing and transduction by endothelial surface glycocalyx: composition, structure, and function

Focus Article
Bingmei M. Fu, John M. Tarbell
Published Online: Feb 07 2013
DOI:10.1002/wsbm.1211

Abstract Full article on Wiley Online Library:   HTML | PDF
Model‐based design of experiments for cellular processes

Advanced Review
Ankush Chakrabarty, Gregery T. Buzzard, Ann E. Rundell
Published Online: Jan 04 2013
DOI:10.1002/wsbm.1204

Abstract Full article on Wiley Online Library:   HTML | PDF
Stem cell bioengineering at the interface of systems‐based models and high‐throughput platforms

Overview
Gregory H. Underhill
Published Online: Aug 23 2012
DOI:10.1002/wsbm.1189

Abstract Full article on Wiley Online Library:   HTML | PDF
Mitochondrial network energetics in the heart

Advanced Review
Miguel A. Aon, Sonia Cortassa
Published Online: Aug 15 2012
DOI:10.1002/wsbm.1188

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology approaches to toll‐like receptor signaling

Focus Article
Alexis Vandenbon, Shunsuke Teraguchi, Shizuo Akira, Kiyoshi Takeda, Daron M. Standley
Published Online: Jun 19 2012
DOI:10.1002/wsbm.1178

Abstract Full article on Wiley Online Library:   HTML | PDF
Hydrogels for in vivo ‐like three‐dimensional cellular studies

Advanced Review
Ross DeVolder, Hyun‐Joon Kong
Published Online: May 21 2012
DOI:10.1002/wsbm.1174

Abstract Full article on Wiley Online Library:   HTML | PDF
Deciphering the complexities of human diseases and disorders by coupling induced‐pluripotent stem cells and systems genetics

Advanced Review
Wing Y. Chang, Kamal Garcha, Janet L. Manias, William L. Stanford
Published Online: Apr 10 2012
DOI:10.1002/wsbm.1170

Abstract Full article on Wiley Online Library:   HTML | PDF
Isotope labeling experiments in metabolomics and fluxomics

Advanced Review
Sebastian Klein, Elmar Heinzle
Published Online: Mar 23 2012
DOI:10.1002/wsbm.1167

Abstract Full article on Wiley Online Library:   HTML | PDF
Theoretical insights into bacterial chemotaxis

Advanced Review
Marcus J. Tindall, Eamonn A. Gaffney, Philip K. Maini, Judith P. Armitage
Published Online: Mar 12 2012
DOI:10.1002/wsbm.1168

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale models of thrombogenesis

Advanced Review
Zhiliang Xu, Oleg Kim, Malgorzata Kamocka, Elliot D. Rosen, Mark Alber
Published Online: Jan 13 2012
DOI:10.1002/wsbm.1160

Abstract Full article on Wiley Online Library:   HTML | PDF
The virtual liver: a multidisciplinary, multilevel challenge for systems biology

Overview
Hermann‐Georg Holzhütter, Dirk Drasdo, Tobias Preusser, Jörg Lippert, Adriano M. Henney
Published Online: Jan 13 2012
DOI:10.1002/wsbm.1158

Abstract Full article on Wiley Online Library:   HTML | PDF
Virtual Cell: computational tools for modeling in cell biology

Advanced Review
Diana C. Resasco, Fei Gao, Frank Morgan, Igor L. Novak, James C. Schaff, Boris M. Slepchenko
Published Online: Dec 02 2011
DOI:10.1002/wsbm.165

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems vaccinology: learning to compute the behavior of vaccine induced immunity

Focus Article
Helder I. Nakaya, Shuzhao Li, Bali Pulendran
Published Online: Oct 19 2011
DOI:10.1002/wsbm.163

Abstract Full article on Wiley Online Library:   HTML | PDF
A multifaceted approach to modeling the immune response in tuberculosis

Focus Article
Simeone Marino, Jennifer J. Linderman, Denise E. Kirschner
Published Online: Dec 31 2010
DOI:10.1002/wsbm.131

Abstract Full article on Wiley Online Library:   HTML | PDF
Simulation of cellular biochemical system kinetics

Opinion
Daniel A. Beard
Published Online: Dec 17 2010
DOI:10.1002/wsbm.116

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrative modeling of the cardiac ventricular myocyte

Advanced Review
Raimond L. Winslow, Sonia Cortassa, Brian O'Rourke, Yasmin L. Hashambhoy, John Jeremy Rice, Joseph L. Greenstein
Published Online: Sep 23 2010
DOI:10.1002/wsbm.122

Abstract Full article on Wiley Online Library:   HTML | PDF
Signaling pathways that control cell migration: models and analysis

Focus Article
Erik S. Welf, Jason M. Haugh
Published Online: Aug 02 2010
DOI:10.1002/wsbm.110

Abstract Full article on Wiley Online Library:   HTML | PDF
Estrogen receptor‐positive breast cancer: a multidisciplinary challenge

Focus Article
Wilbert Zwart, Vasiliki Theodorou, Jason S. Carroll
Published Online: Jul 26 2010
DOI:10.1002/wsbm.109

Abstract Full article on Wiley Online Library:   HTML | PDF
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In the Spotlight

William J. Pavan

William J. Pavan

is interested in using genomic tools to understand how an embryo develops into a functioning organism. His group focuses on neural crest cells, a group of stem cells that differentiate into a wide variety of tissues in the bodys. Issues with the development of the neural crest cells can cause many diseases, ranging from Waardenburg syndrome to cleft lip and palate. Using genomic research tools, Dr. Pavan seeks to identify the genes necessary for normal neural crest cell development, specifically the ones which differentiate into melanocytes. At least 15 genes have been recognized as important in the development of neural crest cells, but there are likely hundreds of genes involved in total. Dr. Pavan’s lab often uses the models of neural crest cell disorders in mice in order to identify the genes needed for normal development. They then study how these genes function, and whether there are corresponding genes in humans that can cause human diseases.

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