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WIREs Syst Biol Med
Impact Factor: 4.275

Computational Methods

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Molecular networks in Network Medicine: Development and applications

Advanced Review
Jan Baumbach, Kimberly Glass, Gemma Vilahur, Davide Viggiano, Paolo Tieri, John Quackenbush, Manuela Petti, Paola Paci, Claudio Napoli, Cinzia Marchese, Joseph Loscalzo, Michele Gentili, Laurent Gatto, Giulia Fiscon, Lorenzo Farina, Antonella Di Costanzo, Federica Conte, Giovambattista Capasso, Giuditta Benincasa, Jean‐Luc Balligand, Lina Badimon, Marco Angelini, Lucia Altucci, Eleni Anastasiadou, Harald H. H. W. Schmidt, Edwin K. Silverman
Published Online: Apr 20 2020
DOI:10.1002/wsbm.1489

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale modeling of vertebrate limb development

Advanced Review
Tilmann Glimm, Ramray Bhat, Stuart A. Newman
Published Online: Mar 24 2020
DOI:10.1002/wsbm.1485

Abstract Full article on Wiley Online Library:   HTML | PDF
Computational models to explore the complexity of the epithelial to mesenchymal transition in cancer

Focus Article
Marilisa Cortesi, Chiara Liverani, Laura Mercatali, Toni Ibrahim, Emanuele Giordano
Published Online: Mar 24 2020
DOI:10.1002/wsbm.1488

Abstract Full article on Wiley Online Library:   HTML | PDF
Aspirin and the chemoprevention of cancers: A mathematical and evolutionary dynamics perspective

Advanced Review
Dominik Wodarz, Ajay Goel, C. Richard Boland, Natalia L. Komarova
Published Online: Mar 12 2020
DOI:10.1002/wsbm.1487

Abstract Full article on Wiley Online Library:   HTML | PDF
Calibration of ionic and cellular cardiac electrophysiology models

Advanced Review
Dominic G. Whittaker, Michael Clerx, Chon Lok Lei, David J. Christini, Gary R. Mirams
Published Online: Feb 21 2020
DOI:10.1002/wsbm.1482

Abstract Full article on Wiley Online Library:   HTML | PDF
Cholesterol interaction motifs in G protein‐coupled receptors: Slippery hot spots?

Advanced Review
Parijat Sarkar, Amitabha Chattopadhyay
Published Online: Feb 07 2020
DOI:10.1002/wsbm.1481

Abstract Full article on Wiley Online Library:   HTML | PDF
How personalized heart modeling can help treatment of lethal arrhythmias: A focus on ventricular tachycardia ablation strategies in post‐infarction patients

Advanced Review
Natalia A. Trayanova, Ashish N. Doshi, Adityo Prakosa
Published Online: Jan 09 2020
DOI:10.1002/wsbm.1477

Abstract Full article on Wiley Online Library:   HTML | PDF
Hybrid modeling frameworks of tumor development and treatment

UPDATE
Ibrahim M. Chamseddine, Katarzyna A. Rejniak
Published Online: Jul 17 2019
DOI:10.1002/wsbm.1461

Abstract Full article on Wiley Online Library:   HTML | PDF
Stochastic simulation algorithms for computational systems biology: Exact, approximate, and hybrid methods

Advanced Review
Luca Marchetti, Corrado Priami, Federico Reali, Giulia Simoni
Published Online: Jul 01 2019
DOI:10.1002/wsbm.1459

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale modeling of the neuromuscular system: Coupling neurophysiology and skeletal muscle mechanics

Advanced Review
Oliver Röhrle, Utku Ş. Yavuz, Thomas Klotz, Francesco Negro, Thomas Heidlauf
Published Online: Jun 24 2019
DOI:10.1002/wsbm.1457

Abstract Full article on Wiley Online Library:   HTML | PDF
IL7 receptor signaling in T cells: A mathematical modeling perspective

Overview
Jung‐Hyun Park, Adam T. Waickman, Joseph Reynolds, Mario Castro, Carmen Molina‐París
Published Online: May 28 2019
DOI:10.1002/wsbm.1447

Abstract Full article on Wiley Online Library:   HTML | PDF
Towards multiscale modeling of the CD8+ T cell response to viral infections

Advanced Review
Subhasish Baral, Rubesh Raja, Pramita Sen, Narendra M. Dixit
Published Online: Feb 27 2019
DOI:10.1002/wsbm.1446

Abstract Full article on Wiley Online Library:   HTML | PDF
Models of polymer physics for the architecture of the cell nucleus

Focus Article
Andrea Esposito, Carlo Annunziatella, Simona Bianco, Andrea M. Chiariello, Luca Fiorillo, Mario Nicodemi
Published Online: Dec 19 2018
DOI:10.1002/wsbm.1444

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrating molecular networks with genetic variant interpretation for precision medicine

Overview
Hannah Carter, Kivilcim Ozturk, Emidio Capriotti
Published Online: Dec 12 2018
DOI:10.1002/wsbm.1443

Abstract Full article on Wiley Online Library:   HTML | PDF
Computational methods for analyzing and modeling genome structure and organization

Focus Article
Dejun Lin, Giancarlo Bonora, Galip Gürkan Yardımcı, William S. Noble
Published Online: Jul 18 2018
DOI:10.1002/wsbm.1435

Abstract Full article on Wiley Online Library:   HTML | PDF
Computational anatomy and diffeomorphometry: A dynamical systems model of neuroanatomy in the soft condensed matter continuum

Advanced Review
Michael I. Miller, Sylvain Arguillère, Daniel J. Tward, Laurent Younes
Published Online: Jun 04 2018
DOI:10.1002/wsbm.1425

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems approaches to optimizing deep brain stimulation therapies in Parkinson’s disease

Overview
Sabato Santaniello, John T. Gale, Sridevi V. Sarma
Published Online: Mar 20 2018
DOI:10.1002/wsbm.1421

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale systems biology of trauma‐induced coagulopathy

Focus Article
Evan Tsiklidis, Carrie Sims, Talid Sinno, Scott L. Diamond
Published Online: Feb 27 2018
DOI:10.1002/wsbm.1418

Abstract Full article on Wiley Online Library:   HTML | PDF
Genome‐scale metabolic models applied to human health and disease

Advanced Review
Jens Nielsen, Daniel J Cook
Published Online: Jun 23 2017
DOI:10.1002/wsbm.1393

Abstract Full article on Wiley Online Library:   HTML | PDF
Image‐based computational fluid dynamics in the lung: virtual reality or new clinical practice?

Advanced Review
Kelly S. Burrowes, Jan De Backer, Haribalan Kumar
Published Online: Jun 13 2017
DOI:10.1002/wsbm.1392

Abstract Full article on Wiley Online Library:   HTML | PDF
Biomechanics of the human uterus

Focus Article
Kristin M. Myers, David Elad
Published Online: May 12 2017
DOI:10.1002/wsbm.1388

Abstract Full article on Wiley Online Library:   HTML | PDF
Virtual endovascular treatment of intracranial aneurysms: models and uncertainty

Advanced Review
Alejandro F. Frangi, Toni Lassila, Ali Sarrami‐Foroushani
Published Online: May 10 2017
DOI:10.1002/wsbm.1385

Abstract Full article on Wiley Online Library:   HTML | PDF
Trends in high‐throughput and functional neuroimaging in Caenorhabditis elegans

Focus Article
Yongmin Cho, Charles L. Zhao, Hang Lu
Published Online: Feb 21 2017
DOI:10.1002/wsbm.1376

Abstract Full article on Wiley Online Library:   HTML | PDF
Multiscale modeling methods in biomechanics

Advanced Review
Pinaki Bhattacharya, Marco Viceconti
Published Online: Jan 19 2017
DOI:10.1002/wsbm.1375

Abstract Full article on Wiley Online Library:   HTML | PDF
Regulatory elements in molecular networks

Advanced Review
Ashley S. Doane, Olivier Elemento
Published Online: Jan 17 2017
DOI:10.1002/wsbm.1374

Abstract Full article on Wiley Online Library:   HTML | PDF
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