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Translational Medicine

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Structural neuroimaging of the altered brain stemming from pediatric and adolescent hearing loss—Scientific and clinical challenges

Advanced Review
J. Tilak Ratnanather
Published Online: Dec 05 2019
DOI:10.1002/wsbm.1469

Abstract Full article on Wiley Online Library:   HTML | PDF
Agent‐based models of inflammation in translational systems biology: A decade later

UPDATE
Gary An, Yoram Vodovotz
Published Online: Jul 01 2019
DOI:10.1002/wsbm.1460

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrating molecular networks with genetic variant interpretation for precision medicine

Overview
Emidio Capriotti, Kivilcim Ozturk, Hannah Carter
Published Online: Dec 12 2018
DOI:10.1002/wsbm.1443

Abstract Full article on Wiley Online Library:   HTML | PDF
PharmGKB: A worldwide resource for pharmacogenomic information

Advanced Review
Julia M. Barbarino, Michelle Whirl‐Carrillo, Russ B. Altman, Teri E. Klein
Published Online: Feb 23 2018
DOI:10.1002/wsbm.1417

Abstract Full article on Wiley Online Library:   HTML | PDF
Human microbiota, blood group antigens, and disease

Advanced Review
D. Rose Ewald, Susan C.J. Sumner
Published Online: Jan 09 2018
DOI:10.1002/wsbm.1413

Abstract Full article on Wiley Online Library:   HTML | PDF
Biomechanics of the human uterus

Focus Article
David Elad, Kristin M. Myers
Published Online: May 12 2017
DOI:10.1002/wsbm.1388

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrated precision medicine: the role of electronic health records in delivering personalized treatment

Focus Article
Amy Sitapati, Hyeoneui Kim, Barbara Berkovich, Rebecca Marmor, Siddharth Singh, Robert El‐Kareh, Brian Clay, Lucila Ohno‐Machado
Published Online: Feb 16 2017
DOI:10.1002/wsbm.1378

Abstract Full article on Wiley Online Library:   HTML | PDF
Modified mRNA as a therapeutic tool to induce cardiac regeneration in ischemic heart disease

Focus Article
Yoav Hadas, Michael G. Katz, Charles R. Bridges, Lior Zangi
Published Online: Dec 02 2016
DOI:10.1002/wsbm.1367

Abstract Full article on Wiley Online Library:   HTML | PDF
Computational approaches for the identification of cancer genes and pathways

Advanced Review
Christos M. Dimitrakopoulos, Niko Beerenwinkel
Published Online: Nov 11 2016
DOI:10.1002/wsbm.1364

Abstract Full article on Wiley Online Library:   HTML | PDF
Engineering of synthetic gene circuits for (re‐)balancing physiological processes in chronic diseases

Advanced Review
Lina Schukur, Martin Fussenegger
Published Online: Jun 24 2016
DOI:10.1002/wsbm.1345

Abstract Full article on Wiley Online Library:   HTML | PDF
Mathematical models of breast and ovarian cancers

Advanced Review
Dana‐Adriana Botesteanu, Stanley Lipkowitz, Jung‐Min Lee, Doron Levy
Published Online: Jun 03 2016
DOI:10.1002/wsbm.1343

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems medicine in colorectal cancer: from a mathematical model toward a new type of clinical trial

Advanced Review
Nicoletta Castagnino, Massimo Maffei, Lorenzo Tortolina, Gabriele Zoppoli, Daniela Piras, Alessio Nencioni, Eva Moran, Alberto Ballestrero, Franco Patrone, Silvio Parodi
Published Online: May 30 2016
DOI:10.1002/wsbm.1342

Abstract Full article on Wiley Online Library:   HTML | PDF
In silico methods for drug repurposing and pharmacology

Overview
Rachel A. Hodos, Brian A. Kidd, Khader Shameer, Ben P. Readhead, Joel T. Dudley
Published Online: Apr 15 2016
DOI:10.1002/wsbm.1337

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology approaches for identifying adverse drug reactions and elucidating their underlying biological mechanisms

Advanced Review
Mary Regina Boland, Alexandra Jacunski, Tal Lorberbaum, Joseph D. Romano, Robert Moskovitch, Nicholas P. Tatonetti
Published Online: Nov 12 2015
DOI:10.1002/wsbm.1323

Abstract Full article on Wiley Online Library:   HTML | PDF
Integrative biomarker discovery in neurodegenerative diseases

Overview
André V. Carreiro, Alexandre Mendonça, Mamede de Carvalho, Sara C. Madeira
Published Online: Jul 02 2015
DOI:10.1002/wsbm.1310

Abstract Full article on Wiley Online Library:   HTML | PDF
Genome‐wide association studies in biliary atresia

Advanced Review
Mylarappa Ningappa, Jun Min, Brandon W. Higgs, Chethan Ashokkumar, Sarangarajan Ranganathan, Rakesh Sindhi
Published Online: May 11 2015
DOI:10.1002/wsbm.1303

Abstract Full article on Wiley Online Library:   HTML | PDF
Parsing interindividual drug variability: an emerging role for systems pharmacology

Advanced Review
Richard M. Turner, B. Kevin Park, Munir Pirmohamed
Published Online: May 07 2015
DOI:10.1002/wsbm.1302

Abstract Full article on Wiley Online Library:   HTML | PDF
Network pharmacodynamic models for customized cancer therapy

Focus Article
James M. Gallo, Marc R. Birtwistle
Published Online: Apr 24 2015
DOI:10.1002/wsbm.1300

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems medicine: evolution of systems biology from bench to bedside

Overview
Rui‐Sheng Wang, Bradley A. Maron, Joseph Loscalzo
Published Online: Apr 17 2015
DOI:10.1002/wsbm.1297

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems engineering meets quantitative systems pharmacology: from low‐level targets to engaging the host defenses

Opinion
Ioannis P. Androulakis
Published Online: Mar 16 2015
DOI:10.1002/wsbm.1294

Abstract Full article on Wiley Online Library:   HTML | PDF
A practical model for economic evaluation of tissue‐engineered therapies

Focus Article
Tien‐En Tan, Gary S. L. Peh, Eric A. Finkelstein, Jodhbir S. Mehta
Published Online: Feb 17 2015
DOI:10.1002/wsbm.1292

Abstract Full article on Wiley Online Library:   HTML | PDF
Exploring hypertension genome‐wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics

Advanced Review
Claudia P Cabrera, Fu Liang Ng, Helen R Warren, Michael R Barnes, Patricia B Munroe, Mark J Caulfield
Published Online: Feb 06 2015
DOI:10.1002/wsbm.1290

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of polycystic kidney disease: a critical review

Focus Article
Luis Fernando Menezes, Gregory G. Germino
Published Online: Feb 02 2015
DOI:10.1002/wsbm.1289

Abstract Full article on Wiley Online Library:   HTML | PDF
Personalizing oncology treatments by predicting drug efficacy, side‐effects, and improved therapy: mathematics, statistics, and their integration

Advanced Review
Zvia Agur, Moran Elishmereni, Yuri Kheifetz
Published Online: Mar 06 2014
DOI:10.1002/wsbm.1263

Abstract Full article on Wiley Online Library:   HTML | PDF
Recent advances in computational methodology for simulation of mechanical circulatory assist devices

Advanced Review
Alison L. Marsden, Yuri Bazilevs, Christopher C. Long, Marek Behr
Published Online: Jan 21 2014
DOI:10.1002/wsbm.1260

Abstract Full article on Wiley Online Library:   HTML | PDF
Using systems approaches to address challenges for clinical implementation of pharmacogenomics

Advanced Review
Jason H. Karnes, Sara Van Driest, Erica A. Bowton, Peter E. Weeke, Jonathan D. Mosley, Josh F. Peterson, Joshua C. Denny, Dan M. Roden
Published Online: Dec 06 2013
DOI:10.1002/wsbm.1255

Abstract Full article on Wiley Online Library:   HTML | PDF
Advances in modeling ventricular arrhythmias: from mechanisms to the clinic

Focus Article
Natalia A. Trayanova, Patrick M. Boyle
Published Online: Dec 06 2013
DOI:10.1002/wsbm.1256

Abstract Full article on Wiley Online Library:   HTML | PDF
Using systems biology approaches to understand cardiac inflammation and extracellular matrix remodeling in the setting of myocardial infarction

Advanced Review
Omid Ghasemi, Yonggang Ma, Merry L. Lindsey, Yu‐Fang Jin
Published Online: Nov 08 2013
DOI:10.1002/wsbm.1248

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology‐embedded target validation: improving efficacy in drug discovery

Opinion
Walter Kolch, Boris N. Kholodenko, William Fitzmaurice, Benedikt A. Minke, Drieke Vandamme
Published Online: Nov 08 2013
DOI:10.1002/wsbm.1253

Abstract Full article on Wiley Online Library:   HTML | PDF
Vascular tissue engineering: from in vitro to in situ

Advanced Review
Song Li, Debanti Sengupta, Shu Chien
Published Online: Oct 22 2013
DOI:10.1002/wsbm.1246

Abstract Full article on Wiley Online Library:   HTML | PDF
Agent‐based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity

Advanced Review
C. Anthony Hunt, Ryan C. Kennedy, Sean H. J. Kim, Glen E. P. Ropella
Published Online: Jun 04 2013
DOI:10.1002/wsbm.1222

Abstract Full article on Wiley Online Library:   HTML | PDF
Branched‐chain amino acid supplementation: impact on signaling and relevance to critical illness

Advanced Review
John S. A. Mattick, Kubra Kamisoglu, Marianthi G. Ierapetritou, Ioannis P. Androulakis, Francois Berthiaume
Published Online: Mar 29 2013
DOI:10.1002/wsbm.1219

Abstract Full article on Wiley Online Library:   HTML | PDF
Lower urinary tract development and disease

Advanced Review
Hila Milo Rasouly, Weining Lu
Published Online: Feb 13 2013
DOI:10.1002/wsbm.1212

Abstract Full article on Wiley Online Library:   HTML | PDF
Genomics and epigenomics of colorectal cancer

Advanced Review
Michal‐Ruth Schweiger, Michelle Hussong, Christina Röhr, Hans Lehrach
Published Online: Jan 16 2013
DOI:10.1002/wsbm.1206

Abstract Full article on Wiley Online Library:   HTML | PDF
Can a systems biology approach unlock the mysteries of Kawasaki disease?

Focus Article
Anne H. Rowley
Published Online: Jan 04 2013
DOI:10.1002/wsbm.1202

Abstract Full article on Wiley Online Library:   HTML | PDF
Pharmacogenomics discovery and implementation in genome‐wide association studies era

Opinion
Xiuqin Ni, Wei Zhang, R. Stephanie Huang
Published Online: Nov 27 2012
DOI:10.1002/wsbm.1199

Abstract Full article on Wiley Online Library:   HTML | PDF
Promise of personalized omics to precision medicine

Advanced Review
Rui Chen, Michael Snyder
Published Online: Nov 26 2012
DOI:10.1002/wsbm.1198

Abstract Full article on Wiley Online Library:   HTML | PDF
Mechanisms of memory enhancement

Advanced Review
Sarah A. Stern, Cristina M. Alberini
Published Online: Nov 13 2012
DOI:10.1002/wsbm.1196

Abstract Full article on Wiley Online Library:   HTML | PDF
Stem cell bioengineering at the interface of systems‐based models and high‐throughput platforms

Overview
Gregory H. Underhill
Published Online: Aug 23 2012
DOI:10.1002/wsbm.1189

Abstract Full article on Wiley Online Library:   HTML | PDF
From base pair to bedside: molecular simulation and the translation of genomics to personalized medicine

Advanced Review
David W. Wright, Shunzhou Wan, Nour Shublaq, Stefan J. Zasada, Peter V. Coveney
Published Online: Aug 15 2012
DOI:10.1002/wsbm.1186

Abstract Full article on Wiley Online Library:   HTML | PDF
The role of regulatory T cells in neurodegenerative diseases

Advanced Review
Feng He, Rudi Balling
Published Online: Aug 15 2012
DOI:10.1002/wsbm.1187

Abstract Full article on Wiley Online Library:   HTML | PDF
Recent approaches to the prioritization of candidate disease genes

Advanced Review
Nadezhda T. Doncheva, Tim Kacprowski, Mario Albrecht
Published Online: Jun 11 2012
DOI:10.1002/wsbm.1177

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems pharmacology, pharmacogenetics, and clinical trial design in network medicine

Advanced Review
Joseph Loscalzo, Scott Weiss, Elliott Antman
Published Online: May 11 2012
DOI:10.1002/wsbm.1173

Abstract Full article on Wiley Online Library:   HTML | PDF
Deciphering the complexities of human diseases and disorders by coupling induced‐pluripotent stem cells and systems genetics

Advanced Review
Wing Y. Chang, Kamal Garcha, Janet L. Manias, William L. Stanford
Published Online: Apr 10 2012
DOI:10.1002/wsbm.1170

Abstract Full article on Wiley Online Library:   HTML | PDF
Integration of proteomics into systems biology of cancer

Advanced Review
S. Hanash, M. Schliekelman, Q. Zhang, A. Taguchi
Published Online: Mar 08 2012
DOI:10.1002/wsbm.1169

Abstract Full article on Wiley Online Library:   HTML | PDF
The virtual liver: a multidisciplinary, multilevel challenge for systems biology

Overview
Hermann‐Georg Holzhütter, Dirk Drasdo, Tobias Preusser, Jörg Lippert, Adriano M. Henney
Published Online: Jan 13 2012
DOI:10.1002/wsbm.1158

Abstract Full article on Wiley Online Library:   HTML | PDF
Engineered tissue grafts: opportunities and challenges in regenerative medicine

Focus Article
Adam W. Feinberg
Published Online: Oct 19 2011
DOI:10.1002/wsbm.164

Abstract Full article on Wiley Online Library:   HTML | PDF
A systems biology approach to synovial joint lubrication in health, injury, and disease

Overview
Alexander Y. Hui, William J. McCarty, Koichi Masuda, Gary S. Firestein, Robert L. Sah
Published Online: Aug 08 2011
DOI:10.1002/wsbm.157

Abstract Full article on Wiley Online Library:   HTML | PDF
Pathways, networks, and systems medicine—the meeting place of the Aegean and the mind

Editorial Commentary
Shankar Subramaniam, Joseph H. Nadeau
Published Online: Apr 01 2011
DOI:10.1002/wsbm.153

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology and the future of medicine

Opinion
Joseph Loscalzo, Albert‐Laszlo Barabasi
Published Online: Feb 24 2011
DOI:10.1002/wsbm.144

Abstract Full article on Wiley Online Library:   HTML | PDF
Estrogen receptor‐positive breast cancer: a multidisciplinary challenge

Focus Article
Wilbert Zwart, Vasiliki Theodorou, Jason S. Carroll
Published Online: Feb 08 2011
DOI:10.1002/wsbm.109

Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling of blood flow in arterial trees

Focus Article
Tomer Anor, Leopold Grinberg, Hyoungsu Baek, Joseph R. Madsen, Mahesh V. Jayaraman, George E. Karniadakis
Published Online: Aug 04 2010
DOI:10.1002/wsbm.90

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems medicine—viewed through the real and computing lenses

Editorial Commentary
Shankar Subramaniam, Joseph H. Nadeau
Published Online: Jun 15 2010
DOI:10.1002/wsbm.103

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems Biology and Medicine—Metazoan Life and Processes

Editorial Commentary
Shankar Subramaniam, Joseph H. Nadeau
Published Online: Apr 09 2010
DOI:10.1002/wsbm.99

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of pro‐angiogenic therapies targeting the VEGF system

Focus Article
Feilim Mac Gabhann, Amina A. Qutub, Brian H. Annex, Aleksander S. Popel
Published Online: Apr 07 2010
DOI:10.1002/wsbm.92

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems Biology and Medicine—Meta‐Issues and Frameworks

Editorial Commentary
Shankar Subramaniam, Joseph H. Nadeau
Published Online: Mar 26 2010
DOI:10.1002/wsbm.98

Abstract Full article on Wiley Online Library:   HTML | PDF
Toward a VPH/Physiome ToolKit

Overview
Alan Garny, Jonathan Cooper, Peter J. Hunter
Published Online: Mar 26 2010
DOI:10.1002/wsbm.63

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology—old wine in a new bottle or is the bottle changing the wine?

Editorial Commentary
Joseph H. Nadeau, Shankar Subramaniam
Published Online: Jan 15 2010
DOI:10.1002/wsbm.91

Abstract Full article on Wiley Online Library:   HTML | PDF
Pharmacogenomics: a systems approach

Overview
Liewei Wang
Published Online: Jan 15 2010
DOI:10.1002/wsbm.42

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems Biology and Medicine—Plunging into the Unknown

Editorial Commentary
Shankar Subramaniam, Joseph H. Nadeau
Published Online: Nov 17 2009
DOI:10.1002/wsbm.80

Abstract Full article on Wiley Online Library:   HTML | PDF
Kidney modeling and systems physiology

Advanced Review
S. Randall Thomas
Published Online: Sep 22 2009
DOI:10.1002/wsbm.14

Abstract Full article on Wiley Online Library:   HTML | PDF
Computational modeling of epithelial tissues

Advanced Review
Rod Smallwood
Published Online: Sep 22 2009
DOI:10.1002/wsbm.18

Abstract Full article on Wiley Online Library:   HTML | PDF
Parts of the Whole

Editorial Commentary
Joseph H. Nadeau, Shankar Subramaniam
Published Online: Sep 22 2009
DOI:10.1002/wsbm.66

Abstract Full article on Wiley Online Library:   HTML | PDF
The lung physiome: merging imaging‐based measures with predictive computational models

Advanced Review
Merryn H. Tawhai, Eric A. Hoffman, Ching‐Long Lin
Published Online: May 05 2009
DOI:10.1002/wsbm.17

Abstract Full article on Wiley Online Library:   HTML | PDF
Systems Biology and Medicine: A New Take on an Old Paradigm

Editorial Commentary
Joseph H. Nadeau, Shankar Subramaniam
Published Online: May 05 2009
DOI:10.1002/wsbm.34

Abstract Full article on Wiley Online Library:   HTML | PDF
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