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WIREs Dev Biol

Fertilization to Gastrulation

Cytoplasmic localization and reorganization in ascidian eggs: role of postplasmic/PEM RNAs in axis formation and fate determination

Advanced Review
Kazuhiro W. Makabe, Hiroki Nishida
Published Online: Apr 09 2012

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Cortical rotation and messenger RNA localization in Xenopus axis formation

Advanced Review
Douglas W. Houston
Published Online: Jan 19 2012

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The maternal muscle determinant in the ascidian egg

Focus Article
Hiroki Nishida
Published Online: Dec 27 2011

Abstract Full article on Wiley Online Library:   HTML | PDF
Early development of cephalochordates (amphioxus)

Linda Z. Holland, Takayuki Onai
Published Online: Dec 05 2011

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In the Spotlight

William J. Pavan

William J. Pavan

is interested in using genomic tools to understand how an embryo develops into a functioning organism. His group focuses on neural crest cells, a group of stem cells that differentiate into a wide variety of tissues in the bodys. Issues with the development of the neural crest cells can cause many diseases, ranging from Waardenburg syndrome to cleft lip and palate. Using genomic research tools, Dr. Pavan seeks to identify the genes necessary for normal neural crest cell development, specifically the ones which differentiate into melanocytes. At least 15 genes have been recognized as important in the development of neural crest cells, but there are likely hundreds of genes involved in total. Dr. Pavan’s lab often uses the models of neural crest cell disorders in mice in order to identify the genes needed for normal development. They then study how these genes function, and whether there are corresponding genes in humans that can cause human diseases.

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