The cause of Parkinson's disease (PD) remains unknown despite it being the second most prevalent neurodegenerative condition. Indeed, there is a growing consensus that there is no single cause, and that PD is a multifactorial systemic condition, in which a number of factors may determine its etiopathogenesis. We describe a systems approach that addresses the multifactorial aspects of PD and overcomes constraints on conventional experimentation imposed by PD's causal complexity, its long temporal duration, and its uniqueness to human brains. Specifically, a mathematical model of brain energy metabolism is used as a core module to which other modules describing cellular processes thought to be associated with PD can be attached and studied in an integrative environment. Employing brain energy usage as the core of a systems approach also enables the potential role that compromised energy metabolism may have in the etiology of PD. Although developed for PD, it has not escaped our attention that the energy systems approach outlined here could also be applied to other neurodegenerative disorders—most notably Alzheimer's disease. WIREs Syst Biol Med 2011 3 1–6 DOI: 10.1002/wsbm.107
WIREs Syst Biol Med
An energy systems approach to Parkinson's disease
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earned her Ph.D. at the University of Pennsylvania and has been at Duke University since 1993. She earned her endowed professorship, the James B. Duke Professor of Cell Biology, for the meaningful discoveries she has made since her postdoctoral work in genetics at the National Institute for Medical Research in London. The broad goal of the research in Dr. Capel’s laboratory is to characterize the cellular and molecular basis of morphogenesis – how the body forms. She uses gonadal (gender/sex) development in the mouse as her model system and investigates a gene she helped discover, Sry, the male sex determining gene. Gonad development is unique in that a single rudimentary tissue can be induced to form one of two different organs, an ovary or testis, and she is learning all she can about this central mystery of biology.Learn More