This Title All WIREs
How to cite this WIREs title:
WIREs Syst Biol Med
Impact Factor: 3.027

Central dopaminergic circuitry controlling food intake and reward: implications for the regulation of obesity

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Prevalence of obesity in the general population has increased in the past 15 years from 15% to 35%. With increasing obesity, the coincident medical and social consequences are becoming more alarming. Control over food intake is crucial for the maintenance of body weight and represents an important target for the treatment of obesity. Central nervous system mechanisms responsible for control of food intake have evolved to sense the nutrient and energy levels in the organism and to coordinate appropriate responses to adjust energy intake and expenditure. This homeostatic system is crucial for maintenance of stable body weight over long periods of time of uneven energy availability. However, not only the caloric and nutritional value of food but also hedonic and emotional aspects of feeding affect food intake. In modern society, the increased availability of highly palatable and rewarding (fat, sweet) food can significantly affect homeostatic balance, resulting in dysregulated food intake. This review will focus on the role of hypothalamic and mesolimbic/mesocortical dopaminergic (DA) circuitry in coding homeostatic and hedonic signals for the regulation of food intake and maintenance of caloric balance. The interaction of dopamine with peripheral and central indices of nutritional status (e.g., leptin, ghrelin, neuropeptide Y), and the susceptibility of the dopamine system to prenatal insults will be discussed. Additionally, the importance of alterations in dopamine signaling that occur coincidently with obesity will be addressed. Copyright © 2010 John Wiley & Sons, Inc.

This WIREs title offers downloadable PowerPoint presentations of figures for non-profit, educational use, provided the content is not modified and full credit is given to the author and publication.

Download a PowerPoint presentation of all images

Figure 1.

Dopamine interactions in the CNS. Dopamine cells in the VTA express receptors for numerous molecules important in the central regulation of food intake. Dopamine neurons project widely to numerous areas that express D1 and D2 dopamine receptors. There are extensive interactions between these regions. *Note: Receptor colocalization has not been experimentally examined for each receptor subtype.

[ Normal View | Magnified View ]

Browse by Topic

Physiology > Mammalian Physiology in Health and Disease

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts

In the Spotlight

Merryn Tawhai

Merryn Tawhai

Dr. Tawhai is PI for lung modeling activities at the Auckland Bioengineering Institute and adjunct Associate Professor of Biomedical Engineering at the University of Iowa. Her research centers on developing multi-scale and multi-physics computational models of structure and function in the lung. A theme that runs through all of her work is the relationship between regional changes in lung structure or function and standard integrated measurements of the lung that are made at the mouth.

Learn More

Twitter: molecular Follow us on Twitter

    Don’t miss Cytometry Part A Special Issue on Quantitative Phase Imaging for Label-Free Cytometry!… https://t.co/A2CDWOhs6y
    RT @emboreports: Burn whatever you have: Mitofusin 2 deletion protects from insulin resistance. More --> https://t.co/Jpm8nwjsZ5 and https…
    RT @embojournal: Is magnetogenetics the new optogenetics? Nimpf and Keays discuss technology potential and technical hurdles https://t.co/D…