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WIREs Comput Mol Sci
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Software for predicting the 3D structure of RNA molecules

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RNA is not regarded anymore as a simple transfer molecule between DNA and proteins. Indeed, over the past decades a plethora of new functional roles have been assigned to RNA molecules. Such functions are carried out either by RNA molecules alone or through interactions with DNA, other RNA molecules, or proteins. In all cases, the structure that the RNA molecule adopts will impact its function, as it happens with proteins. Therefore, to fully characterize the function of an RNA molecule, its structure needs to be either determined by experiments or predicted by computation. Unfortunately, our knowledge of the atomic mechanism by which RNA molecules adopt their biological active structures is still limited. Such hurdle is now being addressed by the development of new computational methods for RNA structure prediction, which complement experimental methods such as X‐ray crystallography, nuclear magnetic resonance, small‐angle X‐ray scattering, and cryo‐electron microscopy. This software focus is not dedicated to a single computational method but aims at outlining the most adopted methods for computational RNA structure prediction. WIREs Comput Mol Sci 2015, 5:56–61. doi: 10.1002/wcms.1198

RNA structure deposition in the PDB database. The green bars (left y axis) indicate yearly new PDB entries and the red line (right y axis) represents the total number of RNA structures in the PDB database. The data ends in December 2013.
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Software > Simulation Methods
Structure and Mechanism > Computational Biochemistry and Biophysics

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