1 Dinsmore, CE. Urodele limb and tail regeneration in early biological thought: an essay on scientific controversy and social change. Int J Dev Biol 1996, 40:621–627.
2 Nieuwkoop, P, Faber, J. Normal Table of Xenopus laevis (Daudin)
. Garland Publishing, New York, NY: Garland Publishing
3 Dent, JN. Limb regeneration in larvae and metamorphosing individuals of the South African clawed toad. J Morphol 1962, 110:61–77.
4 Stocum, DL, Cameron, JA. Looking proximally and distally: 100 years of limb regeneration and beyond. Dev Dyn 2011, 240:943–968.
5 Page, RB, Voss, SR. Induction of metamorphosis in axolotls (Ambystoma mexicanum
). Cold Spring Harb Protoc 2009, 2009:pdb prot5268.
6 Simon, A, Berg, D, Kirkham, M. Not lost in translation. Sensing the loss and filling the gap during regeneration. Semin Cell Dev Biol 2009, 20:691–696.
7 Grogg, MW, Call, MK, Okamoto, M, Vergara, MN, Del Rio‐Tsonis, K, Tsonis, PA. BMP inhibition‐driven regulation of six‐3 underlies induction of newt lens regeneration. Nature 2005, 438:858–862.
8 Goss, RJ. Principles of Regeneration. New York: Academic Press
9 Mauro, A. Satellite cell of skeletal muscle fibers. J Biophys Biochem Cytol 1961, 9:493–495.
10 Peadon, AM, Singer, M. A quantitative study of forelimb innervation in relation to regenerative capacity in the larval, land stage, and adult forms of Triturus viridescens
. J Exp Zool 1965, 159:337–345.
11 Filoni, S, Paglialunga, L. Effect of denervation on hindlimb regeneration in Xenopus laevis
larvae. Differentiation 1990, 43:10–19.
12 Suzuki, M, Satoh, A, Ide, H, Tamura, K. Nerve‐dependent and ‐independent events in blastema formation during Xenopus froglet
limb regeneration. Dev Biol 2005, 286:361–375.
13 Echeverri, K, Tanaka, EM. Proximodistal patterning during limb regeneration. Dev Biol 2005, 279:391–401.
14 Echeverri, K, Tanaka, EM. Ectoderm to mesoderm lineage switching during axolotl tail regeneration. Science 2002, 298:1993–1996.
15 McHedlishvili, L, Epperlein, HH, Telzerow, A, Tanaka, EM. A clonal analysis of neural progenitors during axolotl spinal cord regeneration reveals evidence for both spatially restricted and multipotent progenitors. Development 2007, 134:2083–2093.
16 Gargioli, C, Slack, JM. Cell lineage tracing during Xenopus
tail regeneration. Development 2004, 131:2669–2679.
17 Amaya, E, Kroll, K. Production of transgenic Xenopus laevis
by restriction enzyme mediated integration and nuclear transplantation. J Vis Exp 2010, 42.
18 Casco‐Robles, MM, Yamada, S, Miura, T, et al. Expressing exogenous genes in newts by transgenesis. Nat Protoc 2011, 6:600–608.
19 Khattak, S, Richter, T, Tanaka, EM. Generation of transgenic axolotls (Ambystoma mexicanum
). Cold Spring Harb Protoc 2009, 2009:pdb prot5264.
20 Ogino, H, McConnell, WB, Grainger, RM. High‐throughput transgenesis in Xenopus
using I‐SceI meganuclease. Nat Protoc 2006, 1:1703–1710.
21 Ferretti, P, Brockes, JP. Culture of newt cells from different tissues and their expression of a regeneration‐associated antigen. J Exp Zool 1988, 247:77–91.
22 Tanaka, EM. Regeneration: if they can do it, why can`t we? Cell 2003, 113:559–562.
23 Nye, HL, Cameron, JA, Chernoff, EA, Stocum, DL. Regeneration of the urodele limb: a review. Dev Dyn 2003, 226:280–294.
24 Iten, LE, Bryant, SV. Forelimb regeneration from different levels of amputation in the newt, Notophthalmus viridescens
: length, rate and stages. Roux` Arch Entwickl Mech Org 1973, 173:263–282.
25 Brockes, JP, Kumar, A. Plasticity and reprogramming of differentiated cells in amphibian regeneration. Nat Rev Mol Cell Biol 2002, 3:566–574.
26 Scharner, J, Zammit, PS. The muscle satellite cell at 50: the formative years. Skelet Muscle 2011, 1:28.
27 Cameron, JA, Hilgers, AR, Hinterberger, TJ. Evidence that reserve cells are a source of regenerated sdult newt muscle in vitro. Nature 1986, 321:607–610.
28 Kragl, M, Knapp, D, Nacu, E, et al. Cells keep a memory of their tissue origin during axolotl limb regeneration. Nature 2009, 460:60–65.
29 Morrison, JI, Loof, S, He, P, Simon, A. Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population. J Cell Biol 2006, 172:433–440.
30 Hay, ED. Electron microscopic observations of muscle dedifferentiation in regenerating Amblystoma
limbs. Dev Biol 1959, 1:555–585.
31 Mauro, A, Shafiq, SA, Milhorat, AT. Regeneration of Striated Muscle and Myogenesis. Amsterdam: Excerpta Medica
32 Calve, S, Simon, HG. High resolution three‐dimensional imaging: evidence for cell cycle reentry in regenerating skeletal muscle. Dev Dyn 2011, 240:1233–1239.
33 Hay, ED, Fischman, DA. Origin of the blastema in regenerating limbs of the newt Triturus viridescens
. Dev Biol 1961, 3:26–59.
34 Kumar, A, Velloso, CP, Imokawa, Y, Brockes, JP. Plasticity of retrovirus‐labelled myotubes in the newt limb regeneration blastema. Dev Biol 2000, 218:125–136.
35 Lo, DC, Allen, F, Brockes, JP. Reversal of muscle differentiation during urodele limb regeneration. Proc Natl Acad Sci U S A 1993, 1:7230–7234.
36 Lepilina, A, Coon, AN, Kikuchi, K, Holdway, JE, Roberts, RW, Burns, CG, Poss, KD. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell Nov 2006,127:607–619.
37 Kikuchi, K, Holdway, JE, Werdich, AA, Anderson, RM, Fang, Y, Egnaczyk, GF, Evans, T, MacRae, CA, Stainier, DYR, Poss, KD. Primary contribution to zebrafish heart regeneration by gata4+
cardiomyocytes. Nature 2010, 464:601–605.
38 Jopling, C, Sleep, E, Raya, M, Marti, M, Raya, A, Belmonte, JC. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature 2010, 464:606–609.
39 Knopf, F, Hammond, C, Chekuru, A, et al. Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Dev Cell 2011, 17:713–724.
40 Sousa, S, Afonso, N, Bensimon‐Brito, A, et al. Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration. Development 2011, 138:3897–3905.
41 Tanaka, EM, Reddien, PW. The cellular basis for animal regeneration. Dev Cell 2011, 21:172–185.
42 Morrison, JI, Borg, P, Simon, A. Plasticity and recovery of skeletal muscle satellite cells during limb regeneration. Faseb J 2010, 24:750–756.
43 Borgens, RB. Mice regrow the tips of their foretoes. Science 1982, 217:747–750.
44 Neufeld, DA, Zhao, W. Bone regrowth after digit tip amputation in mice is equivalent in adults and neonates. Wound Repair Regen 1995, 3:461–466.
45 Reginelli, AD, Wang, YQ, Sassoon, D, Muneoka, K. Digit tip regeneration correlates with regions of Msx1 (Hox 7) expression in fetal and newborn mice. Development 1995, 121:1065–1076.
46 Rinkevich, Y, Lindau, P, Ueno, H, Longaker, MT, Weissman, IL. Germ‐layer and lineage‐restricted stem/progenitors regenerate the mouse digit tip. Nature 2011, 476:409–413.
47 Lehoczky, JA, Robert, B, Tabin, CJ. Mouse digit tip regeneration is mediated by fate‐restricted progenitor cells. Proc Natl Acad Sci U S A 2011, 108:20609–20614.
48 Chalkley, DT. A quantitative histological analysis of forelimb regeneration in Triturus visidescens
. J Morphol 1954, 94:21–70.
49 Thornton, CS, Thornton, MT. The regeneration of accessory limb parts following epidermal cap transplantation in urodeles. Experimentia 1965, 21:146–148.
50 Nacu, E, Tanaka, EM. Limb regeneration: a new development? Annu Rev Cell Dev Biol 2011, 27:409–440.
51 Yokoyama, H, Ogino, H, Stoick‐Cooper, CL, Grainger, RM, Moon, RT. Wnt/beta‐catenin signaling has an essential role in the initiation of limb regeneration. Dev Biol 2007, 306:170–178.
52 Kawakami, Y, Rodriguez Esteban, C, Raya, M, et al. Wnt/beta‐catenin signaling regulates vertebrate limb regeneration. Genes Dev 2006, 20:3232–3237.
53 Yokoyama, H, Maruoka, T, Ochi, H, et al. Different requirement for Wnt/beta‐catenin signaling in limb regeneration of larval and adult Xenopus
. PLoS One 2011, 6:e21721.
54 Beck, CW, Christen, B, Barker, D, Slack, JM. Temporal requirement for bone morphogenetic proteins in regeneration of the tail and limb of Xenopus
tadpoles. Mech Dev 2006, 123:674–688.
55 Guimond, JC, Levesque, M, Michaud, PL, et al. BMP‐2 functions independently of SHH signaling and triggers cell condensation and apoptosis in regenerating axolotl limbs. BMC Dev Biol 2010, 10:15.
56 Imokawa, Y, Yoshizato, K. Expression of sonic hedgehog gene in regenerating newt limb blastemas recapitulates that in developing limb buds. Proc Natl Acad Sci U S A 1997, 94:9159–9164.
57 Levesque, M, Gatien, S, Finnson, K, et al. Transforming growth factor: beta signaling is essential for limb regeneration in axolotls. PLoS One 2007, 2:e1227.
58 Vinarsky, V, Atkinson, DL, Stevenson, TJ, Keating, MT, Odelberg, SJ. Normal newt limb regeneration requires matrix metalloproteinase function. Dev Biol 2005, 279:86–98.
59 Yang, EV, Gardiner, DM, Carlson, MR, Nugas, CA, Bryant, SV. Expression of Mmp‐9 and related matrix metalloproteinase genes during axolotl limb regeneration. Dev Dyn 1999, 216:2–9.
60 Santosh, N, Windsor, LJ, Mahmoudi, BS, et al. Matrix metalloproteinase expression during blastema formation in regeneration‐competent versus regeneration‐deficient amphibian limbs. Dev Dyn 2011, 240: 1127–1141.
61 Egar, M, Singer, M. A quantitative electron microscope analysis of peripheral nerve in the urodele amphibian in relation to limb regenerative capacity. J Morphol 1971, 133:387–397.
62 Drachman, DB, Singer, M. Regeneration in botulinum‐poisoned forelimbs of the newt, Triturus
. Exp Neurol 1971, 32:1–11.
63 Singer, M, Davis, MH, Scheuing, MR. The influence of atropine and other neuropharmacological substances on regeneration of the forelimb in the adult urodele, Triturus
. J Exp Zool 1960, 143:33–45.
64 Endo, T, Bryant, SV, Gardiner, DM. A stepwise model system for limb regeneration. Dev Biol 2004, 270:135–145.
65 Satoh, A, Graham, GM, Bryant, SV, Gardiner, DM. Neurotrophic regulation of epidermal dedifferentiation during wound healing and limb regeneration in the axolotl (Ambystoma mexicanum
). Dev Biol 2008, 15:321–335.
66 Kumar, A, Godwin, JW, Gates, PB, Garza‐Garcia, AA, Brockes, JP. Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate. Science 2007, 318:772–777.
67 Kumar, A, Delgado, JP, Gates, PB, Neville, G, Forge, A, Brockes, JP. The aneurogenic limb identifies developmental cell interactions underlying vertebrate limb regeneration. Proc Natl Acad Sci U S A 2011, 108:13588–13593.
68 Kumar, A, Nevill, G, Brockes, JP, Forge, A. A comparative study of gland cells implicated in the nerve dependence of salamander limb regeneration. J Anat 2010, 217:16–25.
69 Kumar, A, Gates, PB, Brockes, JP. Positional identity of adult stem cells in salamander limb regeneration. C R Biol 2007, 330:485–490.
70 Blassberg, RA, Garza‐Garcia, A, Janmohamed, A, Gates, PB, Brockes, JP. Functional convergence of signalling by GPI‐anchored and anchorless forms of a salamander protein implicated in limb regeneration. J Cell Sci 2011, 124(pt 1):47–56.
71 Nacu, E, Tanaka, EM. Limb regeneration: a new development? Annu Rev Cell Dev Biol 2010, 27:409–440.
72 Stoick‐Cooper, CL, Moon, RT, Weidinger, G. Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine. Genes Dev 2007, 21:1292–1315.
73 Yakushiji, N, Suzuki, M, Satoh, A, et al. Correlation between Shh expression and DNA methylation status of the limb‐specific Shh enhancer region during limb regeneration in amphibians. Dev Biol 2007, 312:171–182.
74 Sessions, SK, Bryant, SV. Evidence that regenerative ability is an intrinsic property of limb cells in Xenopus
. J Exp Zool 1988, 247:39–44.
75 Stocum, DL, Thoms, SD. Retinoic‐acid‐induced pattern completion in regenerating double anterior limbs of urodeles. J Exp Zool 1984, 232:207–215.
76 da Silva, SM, Gates, PB, Brockes, JP. The newt ortholog of CD59 is implicated in proximodistal identity during amphibian limb regeneration. Dev Cell 2002, 3:547–555.
77 Brockes, JP, Kumar, A. Comparative aspects of animal regeneration. Annu Rev Cell Dev Biol 2008, 24:525–549.
78 Garza‐Garcia, AA, Driscoll, PC, Brockes, JP. Evidence for the local evolution of mechanisms underlying limb regeneration in salamanders. Integr Comp Biol 2010, 50:528–535.
79 Alvarado, AS. Regeneration in the metazoans: why does it happen? Bioessays 2000, 22:578–590.
80 Brockes, JP, Kumar, A, Velloso, CP. Regeneration as an evolutionary variable. J Anat 2001, 199(pt 1–2): 3–11.