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Randomized clinical trials

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Abstract Randomization is widely recognized as a fundamental principle in the design of Phase III clinical trials. It is a way to minimize conscious and unconscious bias among patients and physicians with regard to treatment assignment and treatment acceptability. This paper outlines the advantages and disadvantages of randomization in clinical trials with discussions in permuted blocks, stratified randomization, cluster randomization, and the role of randomization as a basis for inference. Copyright © 2009 John Wiley & Sons, Inc. This article is categorized under: Applications of Computational Statistics > Clinical Trials

The randomization process for a clinical trial.

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Applications of Computational Statistics > Clinical Trials

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