Home
This Title All WIREs
WIREs RSS Feed
How to cite this WIREs title:
WIREs Data Mining Knowl Discov
Impact Factor: 2.111

Leukemia blast cell identification

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Acute leukemia is a heterogeneous group of disorders, characterized by different laboratory and prognostic features. An adequate diagnosis of acute leukemia, based on the identification of a leukemic cell population and the hematopoietic lineage assessment, is the first goal toward defining correct risk stratification of patients and tailoring specific therapies to patients. Diagnosis of acute leukemia underwent an important change since the 1970s when the only available diagnostic tools were cytomorphology and cytochemistry. Nowadays, the development of modern techniques and their combined use in a multimodal approach lead to a better identification and sub‐classification of acute leukemia. Thus, blast identification in acute leukemia required a comprehensive global approach, by combining cytomorphology, cytochemistry, multiparameter flow cytometry (MFC), cytogenetic, fluorescence in situ hybridization (FISH) and molecular genetic methods. At least, new sequencing technologies, such as gene expression profiling (GEP) and whole‐genome sequencing, DNA methylation arrays, and comparative genomic hybridization array, could represent the new frontiers in the characterization of genetic heterogeneity in acute leukemia. WIREs Data Mining Knowl Discov 2015, 5:74–85. doi: 10.1002/widm.1146

MFC morphology template of BM: CD45 and light scatter (SS LOG). (Courtesy by Prof. Giuseppe Basso)
[ Normal View | Magnified View ]
Schematic representation of AML pathogenetic features.
[ Normal View | Magnified View ]

Related Articles

Genomics: An Interdisciplinary View

Browse by Topic

Application Areas > Health Care

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts