1 Burnstock, G. A moment of excitement. Living History Series. The discovery of non‐adrenergic, non‐cholinergic neurotransmission. Physiol News 2004, 56:7–9.
2 Drury, AN, Szent‐Györgyi, A The physiological activity of adenine compounds with special reference to their action upon mamalian heart. J Physiol (London) 1929, 68:213–237.
3 Feldberg, W, Hebb, C. The stimulating action of phosphate compounds on the perfused superior cervical ganglion of the cat. J Physiol 1948, 107: 210–221.
4 Holton, P. The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J Physiol 1959, 145:494–504.
5 Burnstock, G, Campbell, G, Satchell, D, Smythe, A. Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non‐adrenergic inhibitory nerves in the gut. Br J Pharmacol 1970, 40:668–688.
6 Burnstock, G. Purinergic nerves. Pharmacol Rev 1972, 24: 509–581.
7 Burnstock, G. Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev 2007, 87:659–797.
8 Dale, H. Pharmacology and nerve endings. Proc Roy Soc Med 1935, 28:319–332.
9 Su, C, Bevan, JA, Burnstock, G. [3
H]adenosine triphosphate: release during stimulation of enteric nerves. Science 1971, 173:336–338.
10 Burnstock, G. Do some nerve cells release more than one transmitter? Neuroscience 1976, 1:239–248.
11 Burnstock, G. Purinergic cotransmission. Exp Physiol 2009, 94:20–24.
12 Westfall, DP, Stitzel, RE, Rowe, JN. The postjunctional effects and neural release of purine compounds in the guinea‐pig vas deferens. Eur J Pharmacol 1978, 50:27–38.
13 Hoyle, CHV. Purinergic cotransmission: parasympathetic and enteric nerves. Semin Neurosci 1996, 8:207–215.
14 Burnstock, G. %22Introduction: Changing face of autonomic and sensory nerves in the circulation.%22 In: Edvinsson, L, Uddman, R, eds. Vascular Innervation and Receptor mechanisms: New Perspectives
. San Diego: Academic Press Inc
; 1993, 1–22.
15 Belai, A, Burnstock, G. Evidence for coexistence of ATP and nitric oxide in non‐adrenergic, non‐cholinergic (NANC) inhibitory neurones in the rat ileum, colon and anococcygeus muscle. Cell Tissue Res 1994, 278:197–200.
16 Silinsky, EM, Hubbard, JI. Release of ATP from rat motor nerve terminals. Nature 1973, 243:404–405.
17 Richardson, PJ, Brown, SJ. ATP release from affinity‐purified rat cholinergic nerve terminals. J Neurochem 1987, 48:622–630.
18 Sperlagh, B, Sershen, H, Lajtha, A, Vizi, ES. Co‐release of endogenous ATP and [3H]noradrenaline from rat hypothalamic slices: origin and modulation by alpha2‐adrenoceptors. Neuroscience 1998, 82:511–520.
19 Jo, YH, Role, LW. Coordinate release of ATP and GABA at in vitro synapses of lateral hypothalamic neurons. J Neurosci 2002, 22:4794–4804.
20 Krugel, U, Kittner, H, Franke, H, Illes, P. Purinergic modulation of neuronal activity in the mesolimbic dopaminergic system in vivo. Synapse 2003, 47:134–142.
21 Mori, M, Heuss, C, Gahwiler, BH, Gerber, U. Fast synaptic transmission mediated by P2X receptors in CA3 pyramidal cells of rat hippocampal slice cultures. J Physiol 2001, 535:115–123.
22 Pankratov, Y, Lalo, U, Krishtal, O, Verkhratsky, A. Ionotropic P2X purinoreceptors mediate synaptic transmission in rat pyramidal neurones of layer II/III of somato‐sensory cortex. J Physiol 2002, 542:529–536.
23 Pankratov, Y, Lalo, U, Krishtal, O, Verkhratsky, A. P2X receptor‐mediated excitatory synaptic currents in somatosensory cortex. Mol Cell Neurosci 2003, 24:842–849.
24 Pankratov, Y, Castro, E, Miras‐Portugal, MT, Krishtal, O. A purinergic component of the excitatory postsynaptic current mediated by P2X receptors in the CA1 neurons of the rat hippocampus. Eur J Neurosci 1998, 10:3898–3902.
25 Browne, LE, Jiang, LH, North, RA. New structure enlivens interest in P2X receptors. Trends Pharmacol Sci 2010, 31:229–237.
26 Abbracchio, MP, Burnstock, G, Verkhratsky, A, Zimmermann, H. Purinergic signalling in the nervous system: an overview. Trends Neurosci 2009, 32:19–29.
27 Fields, RD, Burnstock, G. Purinergic signalling in neuron‐glia interactions. Nat Rev Neurosci 2006, 7:423–436.
28 Farber, K, Kettenmann, H. Purinergic signaling and microglia. Pflugers Arch 2006, 452:615–621.
29 Gourine, AV, Llaudet, E, Dale, N, Spyer, KM. ATP is a mediator of chemosensory transduction in the central nervous system. Nature 2005, 436:108–111.
30 Hamilton, N, Vayro, S, Kirchhoff, F, Verkhratsky, A, Robbins, J, Gorecki, DC, Butt, AM. Mechanisms of ATP‐ and glutamate‐mediated calcium signaling in white matter astrocytes. Glia 2008, 56:734–749.
31 Kirischuk, S, Moller, T, Voitenko, N, Kettenmann, H, Verkhratsky, A. ATP‐induced cytoplasmic calcium mobilization in Bergmann glial cells. J Neurosci 1995, 15:7861–7871.
32 Kirischuk, S, Scherer, J, Kettenmann, H, Verkhratsky, A. Activation of P2‐purinoreceptors triggered Ca2+
release from InsP3
‐sensitive internal stores in mammalian oligodendrocytes. J Physiol 1995, 483(Pt 1):41–57.
33 Lalo, U, Pankratov, Y, Wichert, SP, Rossner, MJ, North, RA, Kirchhoff, F, Verkhratsky, A. P2X1
subunits form the functional P2X receptor in mouse cortical astrocytes. J Neurosci 2008, 28:5473–5480.
34 North, RA, Verkhratsky, A. Purinergic transmission in the central nervous system. Pflugers Arch 2006, 452:479–485.
35 Edwards, FA, Gibb, AJ, Colquhoun, D. ATP receptor‐mediated synaptic currents in the central nervous system. Nature 1992, 359:144–147.
36 Edwards, FA, Robertson, SJ, Gibb, AJ. Properties of ATP receptor‐mediated synaptic transmission in the rat medial habenula. Neuropharmacology 1997, 36:1253–1268.
37 Burnstock, G, Knight, GE. Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol 2004, 240:31–304.
38 Cook, SP, Vulchanova, L, Hargreaves, KM, Elde, R, McCleskey, EW. Distinct ATP receptors on pain‐sensing and stretch‐sensing neurons. Nature 1997, 387:505–508.
39 Rong, W, Gourine, AV, Cockayne, DA, Xiang, Z, Ford, AP, Spyer, KM, Burnstock, G. Pivotal role of nucleotide P2X2 receptor subunit of the ATP‐gated ion channel mediating ventilatory responses to hypoxia. J Neurosci 2003, 23:11315–11321.
40 Schiedel, AC, Meyer, H, Borrmann, T, Müller, CE. Characterization of high‐affinity adenine binding sites in Achromobacter xylosoxidans isolated from contaminated Tris buffer. Purinergic Signalling 2008, 4:S7–S8.
41 Souslova, V, Cesare, P, Ding, Y, Akopian, AN, Stanfa, L, Suzuki, R, Carpenter, K, Dickenson, A, Boyce, S, Hill, R, et al. Warm‐coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors. Nature 2000, 407:1015–1017.
42 Erlinge, D, Burnstock, G. P2 receptors in cardiovascular regulation and disease. Purinergic Signal 2008, 4:1–20.
43 Harrington, LS, Evans, RJ, Wray, J, Norling, L, Swales, KE, Vial, C, Ali, F, Carrier, MJ, Mitchell, JA. Purinergic 2X1
receptors mediate endothelial dependent vasodilation to ATP. Mol Pharmacol 2007, 72:1132–1136.
44 Harrington, LS, Mitchell, JA. Novel role for P2X receptor activation in endothelium‐dependent vasodilation. Br J Pharmacol 2004, 143:611–617.
45 Brough, D, Le Feuvre, RA, Wheeler, RD, Solovyova, N, Hilfiker, S, Rothwell, NJ, Verkhratsky, A. Ca2+
stores and Ca2+
entry differentially contribute to the release of IL‐1 beta and IL‐1 alpha from murine macrophages. J Immunol 2003, 170:3029–3036.
46 Chen, L, Brosnan, CF. Regulation of immune response by P2X7
receptor. Crit Rev Immunol 2006, 26:499–513.
47 Coutinho‐Silva, R, Knight, GE, Burnstock, G. Impairment of the splenic immune system in P2X2
knockout mice. Immunobiology 2005, 209:661–668.
48 Pelegrin, P, Barroso‐Gutierrez, C, Surprenant, A. P2X7
receptor differentially couples to distinct release pathways for IL‐1β
in mouse macrophage. J Immunol 2008, 180:7147–7157.
49 Vaughan, KR, Stokes, L, Prince, LR, Marriott, HM, Meis, S, Kassack, MU, Bingle, CD, Sabroe, I, Surprenant, A, Whyte, MK. Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11
receptor. J Immunol 2007, 179:8544–8553.
50 Fu, XW, Nurse, CA, Cutz, E. Expression of functional purinergic receptors in pulmonary neuroepithelial bodies and their role in hypoxia chemotransmission. Biol Chem 2004, 385:275–284.
51 Hayashi, T, Kawakami, M, Sasaki, S, Katsumata, T, Mori, H, Yoshida, H, Nakahari, T. ATP regulation of ciliary beat frequency in rat tracheal and distal airway epithelium. Exp Physiol 2005, 90:535–544.
52 Idzko, M, Hammad, H, van Nimwegen, M, Kool, M, Willart, MA, Muskens, F, Hoogsteden, HC, Luttmann, W, Ferrari, D, Di Virgilio, F, et al. Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat Med 2007, 13:913–919.
53 Mounkaila, B, Marthan, R, Roux, E. Biphasic effect of extracellular ATP on human and rat airways is due to multiple P2 purinoceptor activation. Respir Res 2005, 6:143.
54 Burnstock, G. Purinergic receptors as future targets for treatment of functional GI disorders. Gut 2008, 57:1193–1194.
55 Furuzono, S, Nakayama, S, Imaizumi, Y. Purinergic modulation of pacemaker Ca2+
activity in interstitial cells of Cajal. Neuropharmacology 2005, 48:264–273.
56 Giaroni, C, Knight, GE, Zanetti, E, Chiaravalli, AM, Lecchini, S, Frigo, G, Burnstock, G. Postnatal development of P2 receptors in the murine gastrointestinal tract. Neuropharmacology 2006, 50:690–704.
57 Van Crombruggen, K, Van Nassauw, L, Timmermans, JP, Lefebvre, RA. Inhibitory purinergic P2 receptor characterisation in rat distal colon. Neuropharmacology 2007, 53:257–271.
58 Cooke, HJ, Wunderlich, J, Christofi, FL. “The force be with you”: ATP in gut mechanosensory transduction. News Physiol Sci 2003, 18:43–49.
59 Doctor, RB, Matzakos, T, McWilliams, R, Johnson, S, Feranchak, AP, Fitz, JG. Purinergic regulation of cholangiocyte secretion: identification of a novel role for P2X receptors. Am J Physiol Gastrointest Liver Physiol 2005, 288:G779–G786.
60 Dutta, AK, Woo, K, Doctor, RB, Fitz, JG, Feranchak, AP. Extracellular nucleotides stimulate Cl−
currents in biliary epithelia through receptor‐mediated IP3
release. Am J Physiol Gastrointest Liver Physiol 2008, 295:G1004–G1015.
61 Masyuk, AI, Gradilone, SA, Banales, JM, Huang, BQ, Masyuk, TV, Lee, SO, Splinter, PL, Stroope, AJ, Larusso, NF. Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors. Am J Physiol Gastrointest Liver Physiol 2008, 295:G725–G734.
62 Roman, RM, Feranchak, AP, Salter, KD, Wang, Y, Fitz, JG. Endogenous ATP release regulates Cl‐ secretion in cultured human and rat biliary epithelial cells. Am J Physiol 1999, 276:G1391–G1400.
63 Bell, PD, Lapointe, JY, Sabirov, R, Hayashi, S, Peti‐Peterdi, J, Manabe, K, Kovacs, G, Okada, Y. Macula densa cell signaling involves ATP release through a maxi anion channel. Proc Natl Acad Sci USA 2003, 100:4322–4327.
64 Guan, Z, Osmond, DA, Inscho, EW. P2X receptors as regulators of the renal microvasculature. Trends Pharmacol Sci 2007, 28:646–652.
65 Lee, YJ, Park, SH, Han, HJ. ATP stimulates Na+‐glucose cotransporter activity via cAMP and p38 MAPK in renal proximal tubule cells. Am J Physiol Cell Physiol 2005, 289:C1268–C1276.
66 Liu, R, Bell, PD, Peti‐Peterdi, J, Kovacs, G, Johansson, A, Persson, AE. Purinergic receptor signaling at the basolateral membrane of macula densa cells. J Am Soc Nephrol 2002, 13:1145–1151.
67 Vallon, V. P2 receptors in the regulation of renal transport mechanisms. Am J Physiol Renal Physiol 2008, 294:F10–F27.
68 Wildman, SS, King, BF. P2X receptors: epithelial ion channels and regulators of salt and water transport. Nephron Physiol 2008, 108:p60–p67.
69 Chopra, B, Gever, J, Barrick, SR, Hanna‐Mitchell, AT, Beckel, JM, Ford, AP, Birder, LA. Expression and function of rat urothelial P2Y receptors. Am J Physiol Renal Physiol 2008, 294:F821–F829.
70 Ford, AP, Gever, JR, Nunn, PA, Zhong, Y, Cefalu, JS, Dillon, MP, Cockayne, DA. Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br J Pharmacol 2006, 147(suppl 2):S132–S143.
71 Ruggieri, MR , Sr. Mechanisms of disease: role of purinergic signaling in the pathophysiology of bladder dysfunction. Nat Clin Pract Urol 2006, 3:206–215.
72 Werkstrom, V, Andersson, KE. ATP‐ and adenosine‐induced relaxation of the smooth muscle of the pig urethra. BJU Int 2005, 96:1386–1391.
73 Banks, FC, Knight, GE, Calvert, RC, Thompson, CS, Morgan, RJ, Burnstock, G. The purinergic component of human vas deferens contraction. Fertil Steril 2006, 85:932–939.
74 Gur, S, Kadowitz, PJ, Hellstrom, WJ. Purinergic (P2
) receptor control of lower genitourinary tract function and new avenues for drug action: an overview. Curr Pharm Des 2007, 13:3236–3244.
75 Lau, DH, Metcalfe, MJ, Mumtaz, FH, Mikhailidis, DP, Thompson, CS. Purinergic modulation of human corpus cavernosum relaxation. Int J Androl 2007, 32:149–155.
76 Poletto Chaves, LA, Pontelli, EP, Varanda, WA. P2X receptors in mouse Leydig cells. Am J Physiol Cell Physiol 2006, 290:C1009–C1017.
77 Bardini, M, Lee, HY, Burnstock, G. Distribution of P2X receptor subtypes in the rat female reproductive tract at late pro‐oestrus/early oestrus. Cell Tissue Res 2000, 299:105–113.
78 Katugampola, H, Burnstock, G. Purinergic signalling to rat ovarian smooth muscle: changes in P2X receptor expression during pregnancy. Cells Tissues Organs 2004, 178:33–47.
79 Min, K, Munarriz, R, Yerxa, BR, Goldstein, I, Shaver, SR, Cowlen, MS, Traish, AM. Selective P2Y2 receptor agonists stimulate vaginal moisture in ovariectomized rabbits. Fertil Steril 2003, 79:393–398.
80 Papka, RE, Hafemeister, J, Storey‐Workley, M. P2X receptors in the rat uterine cervix, lumbosacral dorsal root ganglia, and spinal cord during pregnancy. Cell Tissue Res 2005, 321:35–44.
81 Piper, AS, Hollingsworth, M. P2‐purinoceptors mediating spasm of the isolated uterus of the non‐pregnant guinea‐pig. Br J Pharmacol 1996, 117:1721–1729.
82 Ziganshin, AU, Zaitcev, AP, Khasanov, AA, Shamsutdinov, AF, Burnstock, G. Term‐dependency of P2 receptor‐mediated contractile responses of isolated human pregnant uterus. Eur J Obstet Gynecol Reprod Biol 2006, 129:128–134.
83 Gallagher, JA. ATP P2 receptors and regulation of bone effector cells. J Musculoskelet Neuronal Interact 2004, 4:125–127.
84 Burnstock, G. %22A basis for distinguishing two types of purinergic receptor.%22 In: Straub, RW, Boils, L, eds. Cell membranhe receptors for drugs and hormones: A multidisciplinary approach
. New York: Raven Press
; 1978, 107–118.
85 Burnstock, G, Kennedy, C. Is there a basis for distinguishing two types of P2‐purinoceptor? Gen Pharmacol 1985, 16:433–440.
86 Brake, AJ, Wagenbach, MJ, Julius, D. New structural motif for ligand‐gated ion channels defined by an ionotropic ATP receptor. Nature 1994, 371:519–523.
87 Lustig, KD, Shiau, AK, Brake, AJ, Julius, D. Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc Natl Acad Sci U S A 1993, 90:5113–5117.
88 Valera, S, Hussy, N, Evans, RJ, Adami, N, North, RA, Surprenant, A, Buell, G. A new class of ligand‐gated ion channel defined by P2x receptor for extracellular ATP. Nature 1994, 371:516–519.
89 Webb, TE, Simon, J, Krishek, BJ, Bateson, AN, Smart, TG, King, BF, Burnstock, G, Barnard, EA. Cloning and functional expression of a brain G‐protein‐coupled ATP receptor. FEBS Lett 1993, 324:219–225.
90 Ralevic, V, Burnstock, G. Receptors for purines and pyrimidines. Pharmacol Rev 1998, 50:413–492.
91 Burnstock, G. Purine and pyrimidine receptors. Cell Mol Life Sci 2007, 64:1471–1483.
92 Nicke, A, Baumert, HG, Rettinger, J, Eichele, A, Lambrecht, G, Mutschler, E, et al. P2X1
receptors form stable trimers: a novel structural motif of ligand‐gated ion channels. Embo J 1998, 17:3016–3028.
93 Burnstock, G, Verkhratsky, A. Evolutionary origins of the purinergic signalling system. Acta Physiol (Oxf) 2009, 195:415–447.
94 Agboh, KC, Webb, TE, Evans, RJ, Ennion, SJ. Functional characterization of a P2X receptor from Schistosoma mansoni. J Biol Chem 2004, 279:41650–41657.
95 Fountain, SJ, Parkinson, K, Young, MT, Cao, L, Thompson, CR, North, RA. An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum. Nature 2007, 448:200–203.
96 Demidchik, V, Nichols, C, Oliynyk, M, Dark, A, Glover, BJ, Davies, JM. Is ATP a signaling agent in plants? Plant Physiol 2003, 133:456–461.
97 Jeter, CR, Roux, SJ. Plant responses to extracellular nucleotides: Cellular processes and biological effects. Purinergic Signal 2006, 2:443–449.
98 Kim, SY, Sivaguru, M, Stacey, G. Extracellular ATP in plants. Visualization, localization, and analysis of physiological significance in growth and signaling. Plant Physiol 2006, 142:984–992.
99 Abbracchio, MP, Burnstock, G. Purinergic signalling: pathophysiological roles. Jpn J Pharmacol 1998, 78:113–145.
100 Burnstock, G, Verkhratsky, A. Long term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death. Cell Death %26 Dis 2010, 1:e9.
101 Burnstock, G. Purinergic signaling and vascular cell proliferation and death. Arterioscler Thromb Vasc Biol 2002, 22:364–373.
102 Burnstock, G. Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells. Pharmacol Rep 2008, 60:12–20.
103 Bodin, P, Burnstock, G. Purinergic signalling: ATP release. Neurochem Res 2001, 26:959–969.
104 Zimmermann, H. Ectonucleotidases in the nervous system. Novartis Found Symp 2006, 276:113–128; discussion 128–130, 233–117, 275–181.
105 Verkhratsky, A, Krishtal, OA, Burnstock, G. Purinoceptors on neuroglia. Mol Neurobiol 2009, 39:190–208.
106 Burnstock, G. Pathophysiology and therapeutic potential of purinergic signaling. Pharmacol Rev 2006, 58:58–86.
107 Bogdanov, YD, Dale, L, King, BF, Whittock, N, Burnstock, G. Early expression of a novel nucleotide receptor in the neural plate of Xenopus embryos. J Biol Chem 1997, 272:12583–12590.
108 Ryten, M, Hoebertz, A, Burnstock, G. Sequential expression of three receptor subtypes for extracellular ATP in developing rat skeletal muscle. Dev Dyn 2001, 221:331–341.
109 Cheung, KK, Chan, WY, Burnstock, G. Expression of P2X purinoceptors during rat brain development and their inhibitory role on motor axon outgrowth in neural tube explant cultures. Neuroscience 2005, 133:937–945.
110 Tew, EMM, Anderson, PN, Burnstock, G. Implantation of the myenteric plexus into the corpus striatum of adult rats: survival of the neurones and glia and interactions with host brain. Restor Neurol Neurosci 1992, 4:311–321.
111 Hopker, VH, Saffrey, MJ, Burnstock, G. Neurite outgrowth of striatal neurons in vitro: involvement of purines in the growth‐promoting effect of myenteric plexus explants. Int J Dev Neurosci 1996, 14:439–451.
112 Grimm, I, Messemer, N, Stanke, M, Gachet, C, Zimmermann, H. Coordinate pathways for nucleotide and EGF signaling in cultured adult neural progenitor cells. J Cell Sci 2009, 122:2524–2533.
113 Burnstock, G, Cocks, T, Kasakov, L, Wong, HK. Direct evidence for ATP release from non‐adrenergic, non‐cholinergic (“purinergic”) nerves in the guinea‐pig taenia coli and bladder. Eur J Pharmacol 1978, 49:145–149.
114 Burnstock, G. %22Purinergic signalling in lower urinary tract.%22 In: Abbracchio, MP, Williams, M, eds. Handbook of Experimental Pharmacology Volume 151/I Purinergic and Pyrimidinergic Signalling I ‐ Molecular, Nervous and Urinogenitary System Function
. Berlin: Springer‐Verlag; 2001, 423–515.
115 Vidal, M, Hicks, PE, Langer, SZ. Differential effects of alpha‐beta‐methylene ATP on responses to nerve stimulation in SHR and WKY tail arteries. Naunyn Schmiedebergs Arch Pharmacol 1986, 332:384–390.
116 Boeynaems, JM, Communi, D, Gonzalez, NS, Robaye, B. Overview of the P2 receptors. Semin Thromb Hemost 2005, 31:139–149.
117 Yerxa, BR. Therapeutic use of nucleotides in respiratory and ophthalmic diseases. Drug Dev Res 2001, 52:196–201.
118 Shabbir, M, Burnstock, G. Purinergic receptor‐mediated effects of adenosine 5′‐triphosphate in urological malignant diseases. Int J Urol 2009, 16:143–150.
119 White, N, Burnstock, G. P2 receptors and cancer. Trends Pharmacol Sci 2006, 27:211–217.
120 Bradbury, EJ, Burnstock, G, McMahon, SB. The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial‐derived neurotrophic factor. Mol Cell Neurosci 1998, 12:256–268.
121 Chen, CC, Akopian, AN, Sivilotti, L, Colquhoun, D, Burnstock, G, Wood, JN. A P2X purinoceptor expressed by a subset of sensory neurons. Nature 1995, 377:428–431.
122 Burnstock, G. A unifying purinergic hypothesis for the initiation of pain. Lancet 1996, 347:1604–1605.
123 Burnstock, G. Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction. J Anat 1999, 194(Pt 3):335–342.
124 Burnstock, G. Purinergic mechanosensory transduction and visceral pain. Mol Pain 2009, 5:69.
125 Vlaskovska, M, Kasakov, L, Rong, W, Bodin, P, Bardini, M, Cockayne, DA, Ford, AP, Burnstock, G. P2X3 knock‐out mice reveal a major sensory role for urothelially released ATP. J Neurosci 2001, 21:5670–5677.
126 Rong, W, Burnstock, G. Activation of ureter nociceptors by exogenous and endogenous ATP in guinea pig. Neuropharmacology 2004, 47:1093–1101.
127 Wynn, G, Burnstock, G. Adenosine 5′‐triphosphate and its relationship with other mediators that activate pelvic nerve afferent neurons in the rat colorectum. Purinergic Signal 2006, 2:517–526.
128 Cockayne, DA, Hamilton, SG, Zhu, QM, Dunn, PM, Zhong, Y, Novakovic, S, Malmberg, AB, Cain, G, Berson, A, Kassotakis, L, et al. Urinary bladder hyporeflexia and reduced pain‐related behaviour in P2X3‐deficient mice. Nature 2000, 407:1011–1015.
129 Inoue, K. P2 receptors and chronic pain. Purinergic Signal 2007, 3:135–144.
130 Burnstock, G. Purinergic receptors and pain. Curr Pharm Des 2009, 15:1717–1735.
131 Burnstock, G. Purinergic signalling and disorders of the central nervous system. Nat Rev Drug Discov 2008, 7:575–590.