References
1 Meeker, RB, Greenwood, RS, Hayward, JN. Glutamate receptors in the rat hypothalamus and pituitary. Endocrinology 1994, 134:624–629.
2 Caruso, C, Durand, D, Watanobe, H, Lasaga, M. NMDA and Group I metabotropic glutamate receptors activation modulates substance P release from the arcuate nucleus and median eminence. Neurosci Lett 2006, 393:60–64.
3 Pampillo, M, Scimonelli, T, Duvilanski, B, Celis, ME, Seilicovich, A, Lasaga, M. The activation of metabotropic glutamate receptors differentially affects GABA and
α‐melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats. Neurosci Lett 2002, 327:95–98.
4 Crown, A, Clifton, DK, Steiner, RA. Neuropeptide signaling in the integration of metabolism and reproduction. Neuroendocrinology 2007, 86:175–182.
5 Brann, DW. Glutamate: a major excitatory transmitter in neuroendocrine regulation. Neuroendocrinology 1995, 61:213–225.
6 Pampillo, M, Theas, S, Duvilanski, B, Seilicovich, A, Lasaga, M. Effect of ionotropic and metabotropic glutamate agonists and D‐aspartate on prolactin release from anterior pituitary cells. Exp Clin Endocrinol Diabetes 2002, 110:138–144.
7 Dumalska, I, Wu, M, Morozova, E, Liu, R, van den Pol, A, Alreja, M. Excitatory effects of the puberty‐initiating peptide kisspeptin and Group I metabotropic glutamate receptor agonists differentiate two distinct subpopulations of gonadotropin‐releasing hormone neurons. J Neurosci 2008, 28:8003–8013.
8 Chu, Z, Moenter, M. Endogenous activation of meta‐ botropic glutamate receptors modulates GABAergic transmission to gonadotropin‐releasing hormone neurons and alters their firing rate: a possible local feedback circuit. J Neurosci 2005, 25:5740–5749.
9 Wright, CL, McCarthy, MM. Prostaglandin E2‐induced masculinization of brain and behavior requires protein kinase A, AMPA/kainate, and metabotropic glutamate receptor signaling. J Neurosci 2009, 29:13274–13282.
10 Lang, CH, Ajmal, M. Metabolic, hormonal, and hemodynamic changes induced by metabotropic excitatory amino acid agonist (1S, 3R)‐ACPD. Am J Physiol 1995, 268:1026–1033.
11 Johnson, MP, Kelly, G, Chamberlain, M. Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists. Neuroendocrinology 2001, 13:670–677.
12 Bradbury, MJ, Giracello, DR, Chapman, DF, Holtz, G, Schaffhauser, H, Rao, SP, Varney, MA, Anderson, JJ. Metabotropic glutamate receptor 5 antagonist‐induced stimulation of hypothalamic‐pituitary‐adrenal axis activity: interaction with serotonergic systems. Neuropharmacology 2003, 44:562–572.
13 Scaccianoce, S, Matrisciano, F, Del Bianco, P, Caricasole, A, Di Giorgi Gerevini, V, Cappuccio, I, Melchiorri, D, Battaglia, G, Nicoletti, F. Endogenous activation of Group II metabotropic glutamate receptors inhibits the hypothalamic‐pituitary‐adrenocortical axis. Neuropharmacology 2003, 44:555–561.
14 Mitsukawa, K, Mombereau, C, Lötscher, E, Uzunov, DP, van der Putten, H, Flor, PJ, Cryan, JF. Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels: implications for stress‐related psychiatric disorders. Neuropsychopharmacology 2006, 31:1112–1122.
15 Mitsukawa, K, Yamamoto, R, Ofner, S, Nozulak, J, Pescott, O, Lukic, S, Stoehr, N, Mombereau, C, Kuhn, R, McAllister, KH, et al. A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc Natl Acad Sci USA 2005, 102:18712–18717.
16 Aguilar, E, Tena‐Sempere, M, Pinilla, L. Role of excitatory amino acids in the control of growth hormone secretion. Endocrine 2005, 28:295–301.
17 Caruso, C, Bottino, MC, Pampillo, M, Pisera, D, Jaita, G, Duvilanski, B, Seilicovich, A, Lasaga, M. Glutamate induces apoptosis in anterior pituitary cells through Group II metabotropic glutamate receptor activation. Endocrinology 2004, 145:4677–4684.
18 Ben‐Jonathan, N, Hnasko, R. Dopamine as a prolactin (PRL) inhibitor. Endocr Rev 2001, 22:724–763.
19 Sarkar, DK, Chaturvedi, K, Oomizu, S, Boyadjieva, NI, Chen, CP. Dopamine, dopamine D2 receptor short isoform, transforming growth factor (TGF)‐
β 1, and TGF‐
β type II receptor interact to inhibit the growth of pituitary lactotropes. Endocrinology 2005, 146: 4179–4188.
20 Brann, DW, Mahesh, VB. Excitatory amino acids: evidence for a role in the control of reproduction and anterior pituitary hormone secretion. Endocrine Rev 1997, 18:678–700.
21 Lasaga, M, De Laurentiis, A, Pampillo, M, Pisera, D, Díaz, M, Theas, S, Duvilanski, B, Seilicovich, A. The effect of excitatory amino acids on GABA release from mediobasal hypothalamus of female rats. Neurosci Lett 1998, 247:119–122.
22 Johnson, MP, Chamberlain, M. Modulation of stress‐induced and stimulated hyperprolactinemia with the Group II metabotropic glutamate receptor selective agonist, Ly 379268. Neuropharmacology 2002, 43: 799–808.
23 Seeman, P, Caruso, C, Lasaga, M. Dopamine partial agonist actions of the glutamate receptor agonists Ly 354,740 and Ly 379,268. Synapse 2008, 62:154–158.
24 Cartmell, J, Perry, KW, Salhoff, CR, Monn, JA, Schoepp, DD. The potent, selective mGlu2/3 receptor agonist Ly 379268 increases extracellular levels of dopamine, 3,4‐dihydroxyphenyl‐acetic acid, homovanillic acid, and 5‐hydroxyindole‐3‐acetic acid in the medial prefrontal cortex of the freely moving rat. J Neurochem 2000, 75:1147–1154.
25 Schoepp, DD, Johnson, BG, Wright, RA, Salhoff, CR, Monn, JA. Potent, stereoselective, and brain region selective modulation of second messengers in the rat brain by (+)Ly354740, a novel Group II metabotropic glutamate receptor agonist. Naunyn Schmiedebergs Arch Pharmacol 1998, 358:175–180.
26 Ferraguti, F, Shigemoto, R. Metabotropic glutamate receptors. Cell Tissue Res 2006, 326:483–504.
27 Tong, Q, Quedraogo, R, Kirchgessner, AL. Localization and function of Group III metabotropic glutamate receptors in rat pancreatic islets. Am J Physiol Endocrinol Metab 2002, 282:1324–1333.
28 Julio‐Pieper, M, Flor, PJ, Dinan, TG, Cryan, JF. Exciting times beyond the brain: metabotropic glutamate receptors in peripheral and non‐neural tissues. Pharmacol Rev 2011, 63:35–58.
29 Balakrishnan, S, T, PK, Paulose, CS. Glutamate (mGluR‐5) gene expression in brain regions of streptozotocin induced diabetic rats as a function of age: role in regulation of calcium release from the pancreatic islets in vitro. J Biomed Sci 2009, 16:99.
30 Anu, J, Peeyush Kumar, T, Nandhu, MS, Paulose, CS. Enhanced NMDAR1, NMDA2B and mGlu5 receptors gene expression in the cerebellum of insulin induced hypoglycaemic and streptozotocin induced diabetic rats. Eur J Pharmacol 2010, 630:61–68.
31 Storto, M, Capobianco, L, Battaglia, G, Molinaro, G, Gradini, R, Riozzi, B, Di Mambro, A, Mitchell, KJ, Bruno, V, Vairetti, MP, et al. Insulin secretion is controlled by mGlu5 metabotropic glutamate receptors. Mol Pharmacol 2006, 69:1234–1241.
32 Brice, NL, Varadi, A, Ashcroft, SJ, Molnar, E. Meta‐ botropic glutamate and GABA(B) receptors contribute to the modulation of glucose‐stimulated insulin secretion in pancreatic
β cells. Diabetologia 2002, 45: 242–252.
33 Uehara, S, Muroyama, A, Echigo, N, Morimoto, R, Otsuka, M, Yatsushiro S, Moriyama Y. Metabotropic glutamate receptor type 4 is involved in autoinhibitory cascade for glucagon secretion by
α‐cells of islet of Langerhans. Diabetes 2004, 53:998–1006.
34 Arce, C, Del Campo, AB, Figueroa, S, López, E, Arán‐ guez, I, Oset‐Gasque MJ, González MP. Expression and functional properties of Group I metabotropic glutamate receptors in bovine chromaffin cells. J Neurosci Res 2004, 75:182–193.
35 Yamada, H, Yatsushiro, S, Ishio, S, Hayashi, M, Nishi, T, Yamamoto, A, Futai, M, Yamaguchi, A, Moriyama, Y. Metabotropic glutamate receptors negatively regulate melatonin synthesis in rat pinealocytes. J Neurosci 1998, 18:2056–2062.
36 Gill, S, Barker, M, Pulido, O. Neuroexcitatory targets in the female reproductive system of the nonhuman primate (Macaca Fascicularis). Toxicol Pathol 2008, 36: 478–484.
37 Gill, S, Pulido, O. Glutamate receptors in peripheral tissues: current knowledge, future research, and implications for toxicology. Toxicol Pathol 2001, 29:208–223.
38 Takarada, T, Hinoi, E, Balcar, VJ, Taniura, H, Yoneda, Y. Possible expression of functional glutamate transporters in the rat testis. J Endocrinol 2004, 181:233–244.
39 Storto, M, Sallese, M, Salvatore, L, Poulet, R, Condorelli, DF, Dell`Albani, P, Marcello, MF, Romeo, R, Piomboni, P, Barone, N, et al. Expression of metabotropic glutamate receptors in the rat and human testis. J Endocrinol 2001, 170:71–78.
40 Gill, S, Pulido, O.
Glutamate Receptors in Peripheral Tissues. New York:
Kluwer Academic/Plenum Publisher; 2005, 14.
41 Do, SH, Yun, HS, Jeong, WI, Jeong, DH, Ki, MR, Chung, JY, Park, SJ, Kim, SB, Jeong, KS. Up‐regulation of metabotropic glutamate receptor 3 (mGluR3) in rat fibrosis and cirrhosis model of persistent hypoxic condition. Mol Cell Biochem 2007, 294:189–196.
42 Storto, M, De Grazia, U, Knöpfel, T, Canonico, PL, Copani, A, Richelmi, P, Nicoletti, F, Vairetti, M. Selective blockade of mGluR5 metabotropic glutamate receptors protects rat hepatocytes against hypoxic damage. Hepatology 2000, 31:649–655.
43 Jesse, CR, Wilhelm, EA, Bortolatto, CF, Savegnano, L, Nogueira, CW. Selective blockade of mGlu5 metabotropic glutamate receptors is hepatoprotective against fulminant hepatic failure induced by lipopolysaccharide and D‐galactosamine in mice. J Appl Toxicol 2009, 29:323–329.
44 Storto, M, Ngomba, RT, Battaglia, G, Freitas, I, Griffini, P, Richelmi, P, Nicoletti, F, Vairetti, M. Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. J Hepatol 2003, 38:179–187.
45 Storto, M, Battaglia, G, Gradini, R, Bruno, V, Nicoletti, F, Vairetti, M. Mouse hepatocytes lacking mGlu5 metabotropic glutamate receptors are less sensitive to hypoxic damage. Eur J Pharmacol 2004, 497:25–27.
46 Cardona‐Gomez, GP, DonCarlos, L, Garcia‐Segura, LM. Insulin‐like growth factor 1 receptors and oestrogen receptors colocalize in female rat brain. Neuroscience 2000, 99:751–760.
47 Kahlert, S, Nuedling, S, van Eickels, M, Vetter, H, Meyer, R, Grohe, C. Oestrogen receptor
α rapidly activates the IGF‐1 receptor pathway. J Biol Chem 2000, 275:18447–18453.
48 Razandi, M, Pedram, A, Park, ST, Levin, ER. Proximal events in signaling by plasma membrane oestrogen receptors. J Biol Chem 2003, 278:2701–2712.
49 Boulware, MI, Weick, JP, Becklund, BR, Kuo, SP, Groth, RD, Mermelstein, PG. Estradiol activates Group I and II metabotropic glutamate receptor signaling, leading to opposing influences on cAMP response element‐binding protein. J Neurosci 2005, 25:5066–5078.
50 Grove‐Strawser, D, Boulware, MI, Mermelstein, PG. Membrane oestrogen receptors activate the metabotropic glutamate receptors mGluR5 and mGluR3 to bidirectionally regulate CREB phosphorylation in female rat striatal neurons. Neuroscience 2010, 170:1045–1055.
51 Kuo, J, Hariri, OR, Bondar, G, Ogi, J, Micevych, P. Membrane oestrogen receptor‐
α interacts with metabotropic glutamate receptor type 1a to mobilize intracellular calcium in hypothalamic astrocytes. Endocrinology 2009, 150:1369–1376.
52 Dewing, P, Boulware, MI, Sinchak, K, Christensen, A, Mermelstein, PG, Micevych, P. Membrane oestrogen receptor‐
α interactions with metabotropic glutamate receptor 1a modulate female sexual receptivity in rats. J Neurosci 2007, 27:9294–9300.
53 Mermelstein, PG. Membrane‐localised ooestrogen receptor
α and
β influence neuronal activity through activation of metabotropic glutamate receptors. J Neuroendocrinol 2009, 21:257–262.
54 Boulware, MI, Kordasiewics, H, Mermelstein, PG. Caveolin proteins are essential for distinct effects of membrane oestrogen receptors in neurons. J Neurosci 2007, 27:9941–9950.
55 Grove‐Strawser, D, Mermelstein, PG. Oestrogen receptors activate different mGluRs across distinct brain regions. In: Abstract 195.13/XX10 in Society for Neuroscience Annual Meeting. Proceedings, San Diego, California, USA; 2007.
56 Boulware, MI, Mermelstein, PG. Membrane oestrogen receptors activate metabotropic glutamate receptors to influence nervous system physiology. Steroids 2009, 74: 608–613.
57 Micevych, P, Sinchak, K. Synthesis and function of hypothalamic neuro‐progesterone in reproduction. Endocrinology 2008, 149:2739–2742.
58 Fraley, ME. Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia. Expert Opin Ther Pat 2009, 19: 1259–1275.
