Home
This Title All WIREs
WIREs RSS Feed
How to cite this WIREs title:
WIREs Nanomed Nanobiotechnol
Impact Factor: 4.239

Nanoimaging and neurological surgery

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Over 32 million surgical procedures are performed in the United States each year. Increasingly, image guidance is used in order to aid in the surgical localization of pathology, minimization of incisions, and improvement of surgical intervention outcomes. A variety of imaging modalities using different portions of the electromagnetic spectrum are used in neurological surgery. These include wavelengths used in ultrasonography, optical, infrared, ionizing radiation, and magnetic resonance. The use of currently available image‐guidance tools for neurological surgery is reviewed. Advances in nanoparticulates and their integration into the neurosurgical operating room environment are discussed. WIREs Nanomed Nanobiotechnol 2010 2 601–617

Figure 1.

Representative operating room is set up for a craniotomy with optical tracking camera and computer display for stereotactic surgical navigation.

[ Normal View | Magnified View ]
Figure 2.

Closeup of computer display for surgical navigation shows a large left frontal lobe brain tumor. Cross hatches on the screen represent the location of the optical pointer during surgical resection of the tumor.

[ Normal View | Magnified View ]
Figure 3.

Representative nanoparticles that can serve as nanoplatforms for targeted molecular imaging in living subjects are shown.

[ Normal View | Magnified View ]
Figure 4.

Intravenous delivery of QDs via tail vein injections in rat subcutaneous tumor model show the accumulation of QDs 24 h post‐injection.

[ Normal View | Magnified View ]
Figure 5.

Photomicroscopy of rat subcutaneous tumor shown in Figure 4 shows red fluorescent QDs within the green CDllb‐positive macrophages and microglia. Some QDs are also seen in the 4′,6‐diamidino‐2‐phenylindole (DAPI)‐counterstained tumor cells from tumor autophagy of the QDs.

[ Normal View | Magnified View ]
Figure 6.

Preoperative gadolinium‐enhanced (a), USPIO‐enhanced (b), and intraoperative USPIO‐enhanced T1‐weighted MR images (c) from patient with a malignant brain tumor. Panels (b) and (c) were obtained approximately 24 h after USPIO administration.

[ Normal View | Magnified View ]

Browse by Topic

Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery
blog comments powered by Disqus

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts

Twitter: smalljournal Follow us on Twitter

    Highly Conductive, Capacitive, Flexible and Soft Electrodes Based on a 3D Graphene–Nanotube–Palladium Hybrid and... http://t.co/DcLdIpc97j
    Solvent Effects on Polymer Sorting of Carbon Nanotubes with Applications in Printed Electronics http://t.co/cQCY37A0fI
    Layered Double Hydroxide-based Nanomaterials as Highly Efficient Catalysts and Adsorbents http://t.co/jmykgCs2pI