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WIREs Nanomed Nanobiotechnol
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Clinical developments of chemotherapeutic nanomedicines: polymers and liposomes for delivery of camptothecins and platinum (II) drugs

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Abstract For the past 40 years, liposomal and polymeric delivery vehicles have been studied as systems capable of modulating the cytotoxicity of small molecule chemotherapeutics, increasing tumor bearing animal survival times, and improving drug targeting. Although a number of macromolecular‐drug conjugates have progressed to clinical trials, tuning drug release to maintain efficacy in conjunction with controlling drug toxicity has prevented the clinical adoption of many vehicles. In this article, we review the motivations for and approaches to polymer and liposomal delivery with regard to camptothecin and cisplatin delivery. WIREs Nanomed Nanobiotechnol 2013, 5:130–138. doi: 10.1002/wnan.1209 This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Graphic of PEGylated liposome with drug encapsulated in aqueous inner compartment.

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Schematic core‐shell architecture of PEGylated dendrimer loaded with a drug in the interior.

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Increased uptake of macromolecular carriers in tumor tissue as compared to healthy tissue due to the EPR effect. (Reprinted with permission from Ref 10. Copyright 2009 American Chemical Society)

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Platinum (II) drugs approved for use in patients.

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Structure of camptothecin and approved water‐soluble derivatives.

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Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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