Home
This Title All WIREs
WIREs RSS Feed
How to cite this WIREs title:
WIREs Nanomed Nanobiotechnol
Impact Factor: 4.761

Polymer nanoparticles for drug and small silencing RNA delivery to treat cancers of different phenotypes

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Advances in nanotechnology have provided powerful and efficient tools in the development of cancer diagnosis and therapy. There are numerous nanocarriers that are currently approved for clinical use in cancer therapy. In recent years, biodegradable polymer nanoparticles have attracted a considerable attention for their ability to function as a possible carrier for target‐specific delivery of various drugs, genes, proteins, peptides, vaccines, and other biomolecules in humans without much toxicity. This review will specifically focus on the recent advances in polymer‐based nanocarriers for various drugs and small silencing RNA's loading and delivery to treat different types of cancer. WIREs Nanomed Nanobiotechnol 2014, 6:40–60. doi: 10.1002/wnan.1242

Conflict of interest: The authors declare no conflicts of interest.

This WIREs title offers downloadable PowerPoint presentations of figures for non-profit, educational use, provided the content is not modified and full credit is given to the author and publication.

Download a PowerPoint presentation of all images


Schematic illustration of polymer nanoparticles (NPs) formulation for efficient drug delivery for cancer therapy in mouse tumor model.
[ Normal View | Magnified View ]
Polymer nanoparticles can deliver drugs to tumors through passive tissue targeting [enhanced permeability and retention (EPR) effect], which is achieved by extravasation of nanoparticles via enhanced penetrability of the tumor vasculature and ineffective lymphatic drainage. (Reprinted with permission from Ref . Copyright 2007 Nature Publishing Group and from Ref . Copyright 2011 Elsevier Ltd)
[ Normal View | Magnified View ]
Poly(lactide‐co‐glycolide) (PLGA) hydrolysis in the body into biodegradable lactic and glycolic acid.
[ Normal View | Magnified View ]
Histological observation of murine lymphocytic tumors isolated from mice treated with free and nanoparticle‐encapsulated gemcitabine by hematoxylin–eosin–saffron (HES) staining. (Reprinted with permission from Ref . Copyright 2011 American Chemical Society)
[ Normal View | Magnified View ]
Structure and chemistry of the hydrophobic prodrug platinum(IV) compound and active drug, hydrophilic cisplatin, which is released after reduction in the cell. (Reprinted with permission from Ref . Copyright 2008 National Academy of Sciences, U.S.A.)
[ Normal View | Magnified View ]
Tumor cell apoptosis measured by TUNEL staining. (a) Microscopic evaluation of tumor apoptosis by TUNEL staining. (b) Average apoptotic cell counts. Source: Cheng et al.
[ Normal View | Magnified View ]
Docetaxel encapsulated within poly(lactide‐co‐glycolide)‐block‐polyethylene glycol‐COOH (PLGAbPEG‐COOH) polymer nanoparticles (NPs) using the nanoprecipitation method, and conjugated to aptamer for selective delivery to treat prostate cancer. (Reprinted with permission from Ref . Copyright 2007 Elsevier Ltd)
[ Normal View | Magnified View ]

Related Articles

Cancer: An Interdisciplinary View

Browse by Topic

Therapeutic Approaches and Drug Discovery > Oncologic Disease

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts

In the Spotlight

Mauro Ferrari

Mauro Ferrari

started out in mechanical engineering and became interested in nanotechnology with his studies on nanomechanics and nanofluidics. His research work and involvement with setting up some of the premier nano centers and alliances in the world, bringing together universities, hospitals, and federal agencies, showcases interdisciplinarity at work.

Learn More