This Title All WIREs
How to cite this WIREs title:
WIREs Nanomed Nanobiotechnol
Impact Factor: 6.14

Recent progress in the development of polysaccharide conjugates of docetaxel and paclitaxel

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Taxanes are one of the most potent and broadest spectrum chemotherapeutics used clinically, but also induce significant side effects. Different strategies have been developed to produce a safer taxane formulation. Development of polysaccharide drug conjugates has increased in the recent years because of the demonstrated biocompatibility, biodegradability, safety, and low cost of the biopolymers. This review focuses on polysaccharide–taxane conjugates and provides an overview on various conjugation strategies and their effect on the efficacy. Detailed analyses on the designing factors of an effective polysaccharide–drug conjugate are provided with a discussion on the future direction of this field. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

This WIREs title offers downloadable PowerPoint presentations of figures for non-profit, educational use, provided the content is not modified and full credit is given to the author and publication.

Download a PowerPoint presentation of all images

Chemical structures of DTX (a) and PTX (b). Both drugs have been evaluated for polysaccharide‐conjugated delivery. Conjugation of the drug to polymers principally occurs at the reactive 2′‐OH group, which is labeled in blue. (c) Chemical structure of a monosaccharide unit which is the building block of polysaccharides. Monosaccharides linked together covalently by glycosidic linkage to form a polysaccharide. When a single monosaccharide unit is repeated, the resultant polysaccharide is called the homopolysaccharide, whereas, a heteropolysaccharide is composed of two or more types of monosaccharides. There are two anomeric form of monosaccharide: α and β. They are defined by the position of the –OH group at the C‐1 position: in α anomer the –OH group point downward axially and in β anomer the –OH group would point upward equatorially. The numbering system in the monosaccharide is depicted in blue in the figure.
[ Normal View | Magnified View ]
Schematic representation of low MW polymer with low drug loading (1), high MW polymer with low drug loading (2) and high MW polymer with high drug loading (3). With higher drug loading, high MW polymers tend to form complex secondary and tertiary structures in an aqueous medium and can self assemble into core‐shell nanostructures with a hydrophobic drug core which can reduce the hydrolytic release of the drug.
[ Normal View | Magnified View ]
Chemical structures of heparin (a) and heparin–taxane conjugates (b–f).
[ Normal View | Magnified View ]
Chemical structures of chitosan (a) and chitosan–taxane conjugate (b).
[ Normal View | Magnified View ]
Chemical structures of dextran (a), CM–dextran (b), and different dextran–PTX conjugates (c, d).
[ Normal View | Magnified View ]
Chemical structures of carboxymethyl cellulose (a) and CMC–DTX conjugate (b).
[ Normal View | Magnified View ]
Chemical structures of HA (a) and different HA‐taxane conjugates (b–f). HA is composed of glucuronic acid and N‐acetyl glucosamine (a). Mainly carboxylate groups of the glucuronic acid component is used for drug conjugation. In the conjugates, chemical structure of PTX is depicted as PTX for simplification. Linkers are shown in blue colour and PTX is conjugated via the 2′‐OH group. Structures of different conjugates prepared by different groups are shown (b–f).
[ Normal View | Magnified View ]

Browse by Topic

Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts