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WIREs Nanomed Nanobiotechnol
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Nanovector‐mediated drug delivery for spinal cord injury treatment

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Spinal cord injury (SCI) is the result of a traumatic primary event followed by a so‐called secondary injury, which is characterized by a large spectrum of biochemical cellular pathways able to spread the lesion, worsening neurologic recovery. A growing number of potential therapeutic interventions to counteract different neurodegenerative mechanisms of SCI have been proposed, but they did not show relevant efficacy when translated as clinical treatments. Different reasons could explain these disappointing results: on one side the multifactorial evolution of SCI after the primary injury that limits the beneficial effect of just one targeted treatment and, on the other, the restricted access of pharmacological therapies to the spinal cord. For these reasons, recently, a growing interest has been shown in the development of alternative delivery strategies to administer drugs and/or biological/cellular therapies into the spine (hydrogel and nanoparticles). This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement
Selective uptake of polymeric‐based nanoparticles (NPs) into microglia/macrophages in spinal cord injury (SCI). Specific polymeric NPs (poly‐ε‐caprolactone, PCL) are selectively absorbed by activated microglia/macrophages in the injury site. An anti‐inflammatory drug (minocycline) is encapsulated inside the NPs and selectively delivered into microglia/macrophages turning them from a round‐shape phagocytic‐like phenotype to a resting phenotype (anti‐inflammatory effect).
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Schematic overview of nanovector‐mediated delivery strategies to treat spinal cord injury (SCI).
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Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease
Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement

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