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WIREs Nanomed Nanobiotechnol
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Mesoporous silica‐based nanomaterials for drug delivery: evaluation of structural properties associated with release rate

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Abstract We present here a study of the controlled release of amino acid‐derived amphiphilic molecules from the internal pore structure of mesoporous nanoparticle drug delivery systems with different structural properties, namely cubic and hexagonal structures of various degrees of complexity. The internal pore surface of the nanomaterials presented has been functionalised with amine moieties through a one‐pot method. Release profiles obtained by conductivity measurements are interpreted in terms of specific structural and textural parameters of the porous nanoparticles, such as pore geometry and connectivity. Results indicate that diffusion coefficients are lower by as much 4 orders of magnitude in two‐dimensional structures in comparison to three‐dimensional mesoporous solids. A fast release in turn is observed from mesocaged materials AMS‐9 and AMS‐8, where the presence of structural defects is thought to lead to a slightly lower diffusion coefficient in the latter. We conclude that the use of single or mixed phases of these porous systems can be utilized to provide sustained release over long time periods and expect their use in a variety of formulations. Copyright © 2008 John Wiley & Sons, Inc. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Respiratory Disease

Schematic representation of the self‐assembly mechanism of AMS‐n mesoporous materials and the use of the amino acid–derived amphiphile, N‐lauroyl‐glutamic acid, as a model drug. For comparison purpose, the use of the amphiphile as a model drug ensures complete drug loading and complete electrostatic interaction of the model drug with the internal porous surface.

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Representation of the pore wall surface structures of mesoporous materials with 2D hexagonal cylindrical pores (AMS‐3 left), 3D bicontinous cubic cylindrical pores (AMS‐6, middle) and 3D cubic cage‐type pores (AMS‐8 right). Pores sizes and unit cells are not to scale and shown for comparison only.

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Selected release curves for the various types of AMS‐n structures under study. The inset shows a log‐lin plot of the same curves.

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SEM images of calcined samples, with scaling bar length within parenthesis, of (a) AMS‐3 (1 µm), (b) AMS‐6 (1 µm), (c) AMS‐8 (2 µm) and (d) AMS‐9 (2 µm), showing the variation in particle morphology and particle size.

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Therapeutic Approaches and Drug Discovery > Nanomedicine for Respiratory Disease

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