Home
This Title All WIREs
WIREs RSS Feed
How to cite this WIREs title:
WIREs Nanomed Nanobiotechnol
Impact Factor: 4.761

Virus‐based nanoparticles as platform technologies for modern vaccines

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Nanoscale engineering is revolutionizing the development of vaccines and immunotherapies. Viruses have played a key role in this field because they can function as prefabricated nanoscaffolds with unique properties that are easy to modify. Viruses are immunogenic via multiple pathways, and antigens displayed naturally or by engineering on the surface can be used to create vaccines against the cognate virus, other pathogens, specific molecules or cellular targets such as tumors. This review focuses on the development of virus‐based nanoparticle systems as vaccines indicated for the prevention or treatment of infectious diseases, chronic diseases, cancer, and addiction. WIREs Nanomed Nanobiotechnol 2016, 8:554–578. doi: 10.1002/wnan.1383

Human Hepatitis B virus (viperdb.scripps.edu).
[ Normal View | Magnified View ]
Categories of viral vaccines; UV = ultraviolet; VNP = viral nanoparticle; VLP = virus‐like particle.
[ Normal View | Magnified View ]
Nanoparticles as vaccination platforms. (The polymeric assembly was provided by courtsey of Dr. Pokorski)
[ Normal View | Magnified View ]
Human papillomavirus 16L1 capsid (viperdb.scripps.edu).
[ Normal View | Magnified View ]
Production facility at Medicago. The photograph was provided by courtesy of Medicago Inc.
[ Normal View | Magnified View ]
Structure of influenza A virus. Three viral proteins are on the outer surface of virus particles: haemagglutinin (HA), neuraminidase (NA), and M2. Influenza virus matrix protein M1 associates inside the membrane, and the viral genome is packaged into the particle as a ribonucleoprotein in complex with nucleocapsid protein (NP) and viral polymerases (PA, PB1, PB2). (From Tao YJ, Zheng W. Visualizing the Influenza Genome. Science 2012, 338: 1545–1546. Reprinted with permission from AAAS.)
[ Normal View | Magnified View ]
Structure of Ebola virus (Courtesy of David S. Goodsell and RCSB PDB).
[ Normal View | Magnified View ]
Structure of HIV‐1, with structural proteins in blue, viral enzymes in magenta, accessory proteins in green, and viral RNA in yellow. (1) Envelope glycoprotein spike, comprised of transmembrane glycoprotein gp41 and external envelope glycoprotein gp41; (2) lipid membrane; (3) capsid; (4) matrix; (5) viral RNA. (Adapted from Johnson GT, Goodsell DS, Autin L, Forli S, Sanner MF, Olson AJ. 3D molecular models for whole HIV‐1 virions generated with cellPACK. Faraday Discuss 2014, 169:23‐44 – Published by The Royal Society of Chemistry)
[ Normal View | Magnified View ]
Genetic engineering strategies for the display of epitopes on viral coat proteins.
[ Normal View | Magnified View ]
Chemical conjugation strategies (bioconjugation); NHS = N‐hydroxysuccinimde; EDC = 1‐Ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide.
[ Normal View | Magnified View ]
Chemical structures of nicotine (left) and cocaine (right).
[ Normal View | Magnified View ]

Related Articles

Top Ten WNAN Articles

Browse by Topic

Biology-Inspired Nanomaterials > Protein and Virus-Based Structures

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts

In the Spotlight

Mauro Ferrari

Mauro Ferrari

started out in mechanical engineering and became interested in nanotechnology with his studies on nanomechanics and nanofluidics. His research work and involvement with setting up some of the premier nano centers and alliances in the world, bringing together universities, hospitals, and federal agencies, showcases interdisciplinarity at work.

Learn More