Home
This Title All WIREs
WIREs RSS Feed
How to cite this WIREs title:
WIREs Nanomed Nanobiotechnol
Impact Factor: 4.761

Double network hydrogel for tissue engineering

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Double network (DN) hydrogels, a kind of promising soft and tough hydrogels, are produced by two unique contrasting networks with designed network entanglement burst into the field of materials science as versatile functional systems for a very broad range of applications. A part of the DN hydrogels is characterized by extraordinary mechanical properties providing efficient biocompatible and high strength for holding considerable promise in tissue engineering. Following DN hydrogels principles and consideration of biomedical applications, we provide an overall view of the present various DN hydrogels and look forward to the future of DN hydrogels for tissue engineering. In this review, the preparation methods, structure, properties, current situation, and challenges are mainly discussed for the purpose of tissue engineering.

This article is categorized under:

  • Implantable Materials and Surgical Technologies > Nanomaterials and Implants
  • Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement
Schematic illustration of how polyelectrolyte biopolymers facilitate formation of the contrasting double network (DN) structure from a neutral biocompatible polymer. (Reprinted with permission from Wada et al. (). Copyright 2016 elsevier)
[ Normal View | Magnified View ]
Physically–chemically crosslinked double network (DN) hydrogels. (a) Ca2+–alginate–PAAm DN gel and (b) agar–PAAm DN gel
[ Normal View | Magnified View ]
Schematic illustration of the preparation of double network (DN) hydrogels by chemically–chemically crosslinking. (a) Two‐step polymerization method and (b) molecular stent method
[ Normal View | Magnified View ]
Schematic illustration of the preparation of first PAMPS/PAAm DN hydrogels
[ Normal View | Magnified View ]
Classification of hydrogel based on different properties
[ Normal View | Magnified View ]
DN hydrogels for bone tissue engineering. (a) HAp/double network (DN) hydrogels (Reprinted with permission from Silver and Christiansen (). Copyright 2012 wiley) and (b) HAp/SBC/PDMAAm DN hydrogels
[ Normal View | Magnified View ]
The formation process of double network (DN) hydrogels through supramolecular interactions. (a) DNA and CB [8] host–guest supramolecular DN hydrogel and (b) adamantane modified hyaluronic acid (Ad‐HA, brown) and β‐cyclodextrin modified hyaluronic acid (CD‐HA, green) crosslinked through guest–host
[ Normal View | Magnified View ]
Schematic and material properties of SHIELD
[ Normal View | Magnified View ]

Browse by Topic

Implantable Materials and Surgical Technologies > Nanomaterials and Implants
Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts