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WIREs Nanomed Nanobiotechnol
Impact Factor: 6.14

Quantum dots from microfluidics for nanomedical application

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Abstract Nanomedicine, with its advantages of rapid diagnosis, high sensitivity and high accuracy, has aroused extensive interest of researchers, as the cornerstone of nanomedicine, nanomaterials achieve extra attention and rapid development. Among nanomaterials, quantum dots stand out due to their long fluorescence lifetime and excellent antiphotobleaching performance. At present, quantum dots have been applied to the diagnosis and treatment of diseases and various strategies have been presented to fabricate quantum dots. Microfluidic is one promising strategy since microfluidic device can provide an effective platform for the diagnosis of trace disease markers. In this paper, research progress in the microfluidic synthesis of quantum dots and quantum dot‐based nanomedical application is discussed. The classification of quantum dots is firstly introduced, and the researches on quantum dots synthesis based on microfluidic is then mainly described, including the sort, design, preparation of microfluidic synthesis device and its application in synthesis. Nanomedical applications of the quantum dots is especially described and emphasized. The prospects for future development of quantum dots from microfluidic for nanomedical application are finally presented. This article is categorized under: Diagnostic Tools > in vitro Nanoparticle‐Based Sensing
(a) The emission band of semiconductor QDs covers from the ultraviolet to the near infrared. (b) Ten distinguishable fluorecence colors of CdSe QDs. (under a UV lamp, λ = 330–385 nm)
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(a)The scheme of the fabrication process of DOX‐Fe3O4@CNT‐HQDs‐Trf conjugates. (b) Transmission electron microscope images of CNTs, Fe3O4@CNT, and Fe3O4@CNT‐HQDs. (c) Fluorescence images of Hela cells after uptake of DOX‐Fe3O4@CNT‐HQDs‐Trf
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The fluorescence images of DU‐145 and PC‐3 cells of different culture time and dyes after treated by QOX‐loaded GQDs
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(a) Schematic illustration of microRNA detection process on MoS2 platform. (b) Schematic diagram of multiplex microRNA detection by MoS2‐integrated SCCBs. (c) Bright field images and fluorescence images of three kinds of MoS2‐integrated SCCBs after incubating with target miRNA; scale bar is 300 μm
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(a) Scheme diagram of QDs‐doped hydrogel photonic particles for DNA detection in label‐free manner. (b) Layer‐by‐layer fluorescence images of the hydrogel particle. (c) Photoluminescence intensity of hydrogel photonic particles with different QDs concentration and the spectra of the mixture of two kinds QDs with different proportions
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(a)The scheme of radiation‐excited QDs with different colors for bioimaging. (b) Fluorescence images of QDs with different colors for in vitro imaging. (c) Multiplexed imaging of QDs in vivo
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(a)The formation of lipid/QDs composite. (b) The confocal microscope images of the HEK293 cells with (left) or without (right) internalization of QDs into the cytoplasm. (c) The schematic illustration of bioluminescent protein‐QDs conjugates and the fluorescence excitation of QDs by bioluminescence. (d) The fluorescence images of mouse after the injection of labeled cells with a filter (left) and without a filter (right)
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(a) Schematic diagram of the capillary microfluidic generation of double emulsions encapsulating QDs. (b) The fluorescence spectrum and (c) images of QD‐encapsulated core–shell barcodes. (d) Functionalized surface of the barcode particles for protein detection
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(a) Design of microfluidic device with flow‐focusing region to generate droplet reactors for CdTe QDs synthesis. (b) Optical images of QDs fabricated under different temperatures. (c) A variety of QD‐encoded polymer microparticles by tuning the injected ratio of Q545 and Q600
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(a) Continuous‐flow synthesis of functionalized QDs. (b) The formation process of plugs from multiple aqueous streams. (c) Gas–liquid segmented microfluidic reactor with heated and cooled regions to fabricate CdSe QDs
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(a) Transmission electron microscopy (TEM) images of different CsPbX3 (X =Cl‐, Br‐, I‐) QDs. The insets were the fluorescence images (under a UV lamp, λ = 365 nm). (b) Representative PL spectra of different CsPbX3 QDs. (λ = 400 nm for all but 350 nm for CsPbCl3 samples)
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Schematic of (a) heteroatom doped G‐QDs; (b) C‐doped h‐BN QDs; (c) g‐C3N4 QDs with 3 tri‐s‐triazine units and chemical functionalities; (d) TMD QDs and (e) phosphorene QDs
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(a) One‐pot synthesis and purification route for C‐QDs with different PL emissions. (b) Fluorescence images of 8 C‐QD samples (under a UV lamp, λ = 365 nm). (c) Corresponding PL emission spectra of the eight samples
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