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WIREs Nanomed Nanobiotechnol
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Tailoring nanoparticles based on boron dipyrromethene for cancer imaging and therapy

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Abstract Boron dipyrromethene (BODIPY), as a traditional fluorescent dye, has drawn increasing attention because of its excellent photophysical properties like adjustable spectra and outstanding photostability. BODIPY dyes could be assembled into nanoparticles for cancer imaging and therapy via rational design. In this review, the bio‐applications of BODIPY‐containing nanoparticles are introduced in detail, such as cellular imaging, near‐infrared fluorescence imaging, computed tomography imaging, photoacoustic imaging, phototherapy, and theranostics. The construction strategies of BODIPY‐containing nanoparticles are emphasized so the review has three sections—self‐assembly of small molecules, chemical conjugation with hydrophilic compounds, and physical encapsulation. This review not only summarizes various and colorific bio‐applications of BODIPY‐containing nanoparticles, but also provides reasonable design methods of BODIPY‐containing nanoparticles for cancer theranostics. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging
(a) BDP‐decorated mesoporous silica nanoparticles (MSN‐BDP‐PEG) for NIRF imaging, PTT, and Dox loading. (Reprinted with permission from (Y. Zhu et al., . Copyright 2018 Royal Society of Chemistry) (b) BODIPY‐modified nanoscale covalent organic frameworks. (Reprinted with permission from Guan et al. (). Copyright 2019 Cell Press) (c) BODIPY‐containing nanoscale metal–organic frameworks for PDT and CT. Reprinted with permission from W. Wang, Wang, Li, and Xie (). Copyright 2016 Royal Society of Chemistry and T. Zhang, Wang, et al. (). Copyright 2017 Royal Society of Chemistry)
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(a) BDP 7 NPs for PTT and PDT. (Reprinted with permission from Yang Liu et al. (). Copyright 2019 Elsevier B.V.) (b) GSH‐responsive BDP 8 NPs for NIRF, PA, and PTT. (Reprinted with permission from X. Wang, Lin, et al. (). Copyright 2019 Elsevier B.V.) (c) BDP 10 NPs for PTT and PDT (Reprinted with permission from Guo et al. (). Copyright 2016 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
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The molecular structure of BDP 710
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(a) BDP 2 and 3 self‐assemble into nanoparticles. (Reprinted with permission from Y. Liu, Song, et al. (). Copyright 2017 Elsevier B.V.) (b) The self‐assembly, disassembly, cellular uptake of BDP 4 nanocapsules. (Reprinted with permission from Lin, Sun, et al. (). Copyright 2016 Royal Society of Chemistry). (c) BDP 5 NPs with paclitaxel dimer for selectively killing cancer cells (Reprinted with permission from W. Zhang et al. (). Copyright 2016 American Chemical Society)
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The molecular structure of BDP 16
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Constructing BDP NPs for biomedical application
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(a) BDP 13 NPs for PDT and enhanced PDT, FL, and PA imaging. (Reprinted with permission from Qianyun Tang et al. (). Copyright 2017 American Chemical Society) (b) BDP 16 NPs and di‐BDP NPs for PTT and PDT (Reprinted with permission from Ye et al. (). Copyright 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
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The composition of (a) BDP 11 NPs and (b) BDP 12 NPs (Reprinted with permission from Huang, Li, et al. (). Copyright 2017 American Chemical Society and Huang et al. (). Copyright 2016 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
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The molecular structure of BDP 1116
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