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WIREs Nanomed Nanobiotechnol
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Drug‐eluting stent coatings

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Abstract This paper reviews the development of coronary stents from a polymer scientist's view point, and presents the first results of an interdisciplinary team assembled for the development of new stent systems. Poly(styrene‐b‐isobutylene‐b‐styrene) block copolymer (SIBS), a nanostructured thermoplastic elastomer, is used in clinical practice as the drug‐eluting polymeric coating on the Taxus coronary stent (trademark of Boston Scientific Co.). Our group has been developing new architectures comprising of arborescent (dendritic) polyisobutylene cores (D_SIBS), which were shown to be as biocompatible as SIBS. ElectroNanospray (Nanocopoeia Inc.™) was used to coat test coupons and coronary stents with selected DSIBS polymers loaded with dexamethasone, a model drug. The surface topology varied from smooth to nanosized particulate coating. This paper will demonstrate how drug release profiles were influenced by both the molecular weight of the polyisobutylene core and spraying conditions of the polymer‐drug mixture. Copyright © 2009 John Wiley & Sons, Inc. This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials

Raman images (z and x–y scans) of TPE4/DXM smooth films.

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Raman spectra of DXM powder and a TPE4 film.

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DXM release from TPE4, TPE1 and TPE5.• smooth film; o particulate film.

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Scanning electron microscope images of continuous (5000 × magnification) and particulate (20,000 × magnification) films sprayed onto SS plates.

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Polyisobutylene (PIB)‐based Thermoplastic elastomers (TPEs); architecture and macroscopic appearance, where = PIB and= glassy segments.

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Schematic of the ElectroNanospray process.

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Balloon angioplasty and stenting (Reprinted with permission from www.applesnail.net Copyright 2007 Boston Scientific Corporation).

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Stents coated with TPE4/DXM.

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Hybrid coating.

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Optical images of TPE4/DMX continuous films.

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Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials

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