This Title All WIREs
How to cite this WIREs title:
WIREs Nanomed Nanobiotechnol
Impact Factor: 6.14

Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos?

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Abstract Human diseases associated with exposure to asbestos fibers include pleural fibrosis and plaques, pulmonary fibrosis (asbestosis), lung cancer, and diffuse malignant mesothelioma. The critical determinants of fiber bioactivity and toxicity include not only fiber dimensions, but also shape, surface reactivity, crystallinity, chemical composition, and presence of transition metals. Depending on their size and dimensions, inhaled fibers can penetrate the respiratory tract to the distal airways and into the alveolar spaces. Fibers can be cleared by several mechanisms, including the mucociliary escalator, engulfment, and removal by macrophages, or through splitting and chemical modification. Biopersistence of long asbestos fibers can lead to inflammation, granuloma formation, fibrosis, and cancer. Exposure to synthetic carbon nanomaterials, including carbon nanofibers and carbon nanotubes (CNTs), is considered a potential health hazard because of their physical similarities with asbestos fibers. Respiratory exposure to CNTs can produce an inflammatory response, diffuse interstitial fibrosis, and formation of fibrotic granulomas similar to that observed in asbestos‐exposed animals and humans. Given the known cytotoxic and carcinogenic properties of asbestos fibers, toxicity of fibrous nanomaterials is a topic of intense study. The mechanisms of nanomaterial toxicity remain to be fully elucidated, but recent evidence suggests points of similarity with asbestos fibers, including a role for generation of reactive oxygen species, oxidative stress, and genotoxicity. Considering the rapid increase in production and use of fibrous nanomaterials, it is imperative to gain a thorough understanding of their biologic activity to avoid the human health catastrophe that has resulted from widespread use of asbestos fibers. Copyright © 2009 John Wiley & Sons, Inc. This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials

Structure of asbestos fibers by transmission electron microscopy (TEM): (a) serpentine and (b–f) amphiboles. (a) International Union Against Cancer (UICC) asbestos chrysotile ‘A’ standard, (b) UICC asbestos crocidolite standard, Death Valley, California, (c) UICC asbestos anthophyllite standard, (d) winchite‐richterite asbestos, Libby, Montana, (e) tremolite asbestos and (f) UICC asbestos amosite standard. Chrysolite is the only member of the serpentine group. Because of the mismatch in the spacing between the magnesium ions and the silica ions, chrysotile curls into a thin‐rolled, flexible sheet while amphibole fibers are more rigid. Scale bar = 10 μm. (Reprinted with permission from Denver Microbeam Laboratory at the U.S. Geological Survey).

[ Normal View | Magnified View ]

Relationship between aerodynamic diameters of particles and lung deposition. (Reprinted with permission from Ref 28. Copyright 2005 National Institute of Environmental Health Sciences).

[ Normal View | Magnified View ]

Structure of some carbon fibrous nanomaterials by TEM: (a–e) carbon nanofibers (CNFs) and (f–h) Carbon nanotubes (CNTs); (a) Fishbone solid CNFs, (b) Platelet spiral, (c) Stacked‐cup, (d) Platelet‐symmetry, (e) Platelet, (f) single‐wall CNTs, (g) double‐walled CNTs, and (h) multiwalled CNTs. Scale bar= 10 nm. TEM sources: (a) Chen, 2005,15 (b) Bandaru, 2007,16 (c) Vera‐Agullo, 2007,17 (d) Jian, 2006,18 (e) Zheng, 2006,19 (f) www.rsc.org, (g) www.msm.cam.ac.uk, and (h) www.nccr‐nano.org. Inset sources: (a–c, e, f, and h) Martin‐Gullon, 200620 and (d) Jian, 2006.18.

[ Normal View | Magnified View ]

Related Articles

American Society for Nanomedicine, 2010 Conference

Browse by Topic

Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts