Home
This Title All WIREs
WIREs RSS Feed
How to cite this WIREs title:
WIREs RNA
Impact Factor: 4.928

The human mitochondrial transcriptome and the RNA‐binding proteins that regulate its expression

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Abstract The human mitochondrial transcriptome, although produced from a small and compact genome, has revealed surprising complexity in its composition and regulation. Wide variation between individual tRNAs, mRNAs, and rRNAs indicate the importance of post‐transcriptional processing, maturation, and degradation mechanisms in the regulation of mitochondrial gene expression. RNA‐binding proteins play essential roles in controlling the mitochondrial transcriptome from its synthesis to its destruction and have evolved unique features to complement the unusual features of mitochondrial RNAs. Recent studies have shown how changes in mitochondrial RNAs and their binding proteins can have significant effects on human health. This opens new avenues for investigation of mitochondrial RNA‐binding proteins and the mechanisms by which they regulate mitochondrial gene expression. WIREs RNA 2012 doi: 10.1002/wrna.1128 This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications RNA in Disease and Development > RNA in Disease RNA Methods > RNA Analyses In Vitro and In Silico RNA Methods > RNA Analyses in Cells

The human mitochondrial genome (a) and its 11 mRNAs (b). The average length of the poly(A) tail in Hep G2 cells22 is indicated at the 3' end of each mRNA.

[ Normal View | Magnified View ]

Processes and proteins involved in mitochondrial translation.

[ Normal View | Magnified View ]

Processes and proteins involved in mitochondrial mRNA stabilization and decay.

[ Normal View | Magnified View ]

Processes and proteins involved in mitochondrial RNA processing and maturation.

[ Normal View | Magnified View ]

Small and long non‐coding RNAs produced from the human mitochondrial genome. (a) Small non‐coding RNAs derived from tRNALeuUUR and tRNASerAGY . The small RNA frequency in size selected RNA sequencing libraries from 143B osteosarcoma cell mitochondria is represented schematically as intensity of red at each position. (b) Long mitochondrial non‐codingRNAs derived from the ND5, ND6, Cyt b region of the mitochondrial genome as shown schematically, alongside the mRNAs and tRNAs produced from this region.

[ Normal View | Magnified View ]

Browse by Topic

RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
RNA in Disease and Development
RNA Methods > RNA Analyses In Vitro and In Silico
RNA Methods > RNA Analyses in Cells

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts