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Noncoding RNAs: New regulatory code in chondrocyte apoptosis and autophagy

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Abstract Osteoarthritis (OA) is a bone and joint disease characterized by progressive cartilage degradation. In the face of global trends of population aging, OA is expected to become the fourth most common disabling disease by 2020. Nevertheless, the detailed pathogenesis of OA has not yet been elucidated. Noncoding RNAs (ncRNAs), including long noncoding RNAs, microRNAs, and circular RNAs, do not encode proteins but have recently emerged as important regulators of apoptosis and autophagy of chondrocytes, thereby highlighting a potential role in chondrocyte injury leading to OA onset and progression. We here review recent findings on these regulatory roles of ncRNAs to provide new directions for research on the pathogenesis of OA and offer new therapeutic targets for prevention and treatment. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA in Disease and Development > RNA in Development
Schematic mode of long noncoding RNAs (lncRNAs) and promising signaling pathways involved in the chondrocyte injuries. LncRNA stimulated or inhibited diverse targets to impact on chondrocyte apoptosis
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Schematic mode of long noncoding RNAs (lncRNAs), microRNAs, and their promising signaling pathways involved in the chondrocyte injuries. LncRNA and microRNA stimulated or inhibited diverse targets to impact on chondrocyte autophagy
[ Normal View | Magnified View ]
Schematic mode of microRNAs and promising signaling pathways involved in the chondrocyte injuries. MicroRNA stimulated or inhibited diverse targets to impact on chondrocyte apoptosis
[ Normal View | Magnified View ]

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RNA in Disease and Development > RNA in Development
RNA in Disease and Development > RNA in Disease

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