Home
This Title All WIREs
WIREs RSS Feed
How to cite this WIREs title:
WIREs Syst Biol Med
Impact Factor: 2.385

Using a systems biology approach to understand and study the mechanisms of metastasis

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Metastasis remains the main cause for cancer‐related deaths due to the lack of effective therapy. The clonal selection model has long been thought to be the primary mechanism of metastatic progression but many different mechanisms have been hypothesized for the progression from tumorigenesis to the successful dissemination and expansion of tumor cells at the secondary site. MicroRNAs, germline polymorphisms in combination with the tumor microenvironment are few of the different pathways to explain the metastatic cascade. Technological advances for high‐throughput screening of cells such as expression profiling, next generation sequencing, as well as global network analyses have advanced the studies of these mechanisms. Combined with new insights into the various mechanisms of metastasis a systems biology approach has also been shown to be useful in identifying metastasis‐specific gene signatures as well as predicting disease outcome. Furthermore, the results of these studies have been relevant for identifying biomarkers for metastatic disease. WIREs Syst Biol Med 2014, 6:107–114. doi: 10.1002/wsbm.1237

This WIREs title offers downloadable PowerPoint presentations of figures for non-profit, educational use, provided the content is not modified and full credit is given to the author and publication.

Download a PowerPoint presentation of all images


A system biology approach of metastasis. (a) Understanding that metastasis is a complex disease involving many pathways and cell types. (b) Using genetics and next‐generation sequence to understand and study metastasis. (c) Employing expression profiling and network analyses to find disease‐specific signatures. (d) Identifying biomarkers to predict disease and outcome.
[ Normal View | Magnified View ]

Related Articles

Cancer: A Systems Approach
Cancer: An Interdisciplinary View

Browse by Topic

Developmental Biology > Developmental Processes in Health and Disease

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts

In the Spotlight

Jens Nielsen

Jens Nielsen
is a Professor in the Department of Biology and Biological Engineering at Chalmers University of Technology in Göteborg, Sweden. His research focus is on systems biology of metabolism. The yeast Saccharomyces cerevisiae is the lab’s key organism for experimental research, but they also work with Aspergilli oryzae.

Learn More