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WIREs Syst Biol Med
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Systems biology of polycystic kidney disease: a critical review

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The proliferation and diminishing costs of ‘omics’ approaches have finally opened the doors for small and medium laboratories to enter the ‘systems biology era’. This is a welcome evolution that requires a new framework to design, interpret, and validate studies. Here, we highlight some of the challenges, contributions, and prospects of the ‘cyst‐ems biology’ of polycystic kidney disease. WIREs Syst Biol Med 2015, 7:39–52. doi: 10.1002/wsbm.1289 This article is categorized under: Analytical and Computational Methods > Computational Methods Laboratory Methods and Technologies > Genetic/Genomic Methods Translational, Genomic, and Systems Medicine > Translational Medicine
Changes in gene networks reflect aging rather than Pkd1 inactivation. Dendogram summarizing correlation structure of WGCNA module eigengenes and corresponding kidney histology. Results suggest that the network structure changes more dramatically with age than with genotype, in contrast to kidney morphology (arrows: dilated tubes and kidney cysts; red line: arbitrary cut height of dendrogram, separating clusters of correlated eigengenes). (Reprinted with permission from Ref . Copyright 2012 PLoS Genetics).
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Analytical and Computational Methods > Computational Methods
Laboratory Methods and Technologies > Genetic/Genomic Methods
Translational, Genomic, and Systems Medicine > Translational Medicine

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