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WIREs Syst Biol Med
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Systems‐level airway models of bronchoconstriction

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Understanding lung and airway behavior presents a number of challenges, both experimental and theoretical, but the potential rewards are great in terms of both potential treatments for disease and interesting biophysical phenomena. This presents an opportunity for modeling to contribute to greater understanding, and here, we focus on modeling efforts that work toward understanding the behavior of airways in vivo, with an emphasis on asthma. We look particularly at those models that address not just isolated airways but many of the important ways in which airways are coupled both with each other and with other structures. This includes both interesting phenomena involving the airways and the layer of airway smooth muscle that surrounds them, and also the emergence of spatial ventilation patterns via dynamic airway interaction. WIREs Syst Biol Med 2016, 8:459–467. doi: 10.1002/wsbm.1349

This article is categorized under:

  • Analytical and Computational Methods > Dynamical Methods
  • Models of Systems Properties and Processes > Mechanistic Models
  • Models of Systems Properties and Processes > Organ, Tissue, and Physiological Models
(a) Diagram of airway–parenchymal interdependence. (Reprinted with permission from Ref . Copyright 2014 John Wiley & Sons). (b) Basic structure of airway embedded in parenchyma. Black arrows indicate parenchymal tethering forces; white arrows within the smooth muscle layer indicate generation of ASM tension, which serves to constrict the airway.
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Clustered ventilation defects. (a) Experimental image [K‐edge subtraction synchrotron imaging, colored from red (high, 4.0 mg/mL) to black (low, 0.0 mg/mL)]. (Reprinted with permission from Ref . Copyright 2013 American Physiological Society). (b) Simulated ventilation defect pattern simulated using the model of Donovan and Kritter, normalized flow from 0 (blue) to 1 (red). (c) Simulated ventilation defect pattern from the model of Venegas et al., (Reprinted with permission from Ref . Copyright 2014 PLoS) normalized flow from 0 (black) to 1 (yellow).
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Models of Systems Properties and Processes > Organ, Tissue, and Physiological Models
Models of Systems Properties and Processes > Mechanistic Models
Analytical and Computational Methods > Dynamical Methods

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