Home
This Title All WIREs
WIREs RSS Feed
How to cite this WIREs title:
WIREs Syst Biol Med
Impact Factor: 3.542

Data sources for in vivo molecular profiling of human phenotypes

Full article on Wiley Online Library:   HTML PDF

Can't access this content? Tell your librarian.

Molecular profiling of human diseases has been approached at the genetic (DNA), expression (RNA), and proteomic (protein) levels. An important goal of these efforts is to map observed molecular patterns to specific, mechanistic organic entities, such as loci in the genome, individual RNA molecules or defined proteins or protein assemblies. Importantly, such maps have been historically approached in the more intuitive context of a theoretical individual cell, but diseases are better described in reality using an in vivo framework, namely a library of several tissue‐specific maps. In this article, we review the existing data atlases that can be used for this purpose and identify critical gaps that could move the field forward from cellular to in vivo dimensions. WIREs Syst Biol Med 2016, 8:472–484. doi: 10.1002/wsbm.1354 This article is categorized under: Biological Mechanisms > Chemical Biology Laboratory Methods and Technologies > Genetic/Genomic Methods Laboratory Methods and Technologies > Proteomics Methods
(a) Inverse relationship of Omics data volume and causality (PTMome = post‐translational modification‐ome). (b) Relationships of GWAS and true biological entities.
[ Normal View | Magnified View ]
Cross‐tissue expression profile of human Glut1 (gene SLC2A1) from the Human Protein Atlas (a) and BioGPS (b), arrow indicates expression in early erythroid cells.
[ Normal View | Magnified View ]

Related Articles

Parsing interindividual drug variability: an emerging role for systems pharmacology
Building quantitative, three‐dimensional atlases of gene expression and morphology at cellular resolution (WIREs Developmental Biology)
Systems biology approaches to finding novel pain mediators
Aegean Conferences on Pathways, Networks, and Systems Medicine

Browse by Topic

Laboratory Methods and Technologies > Genetic/Genomic Methods
Laboratory Methods and Technologies > Proteomics Methods
Biological Mechanisms > Chemical Biology

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts