1 Miyamura, Y, Coelho, SG, Wolber, R, Miller, SA, Wakamatsu, K, et al.
Regulation of human skin pigmentation and responses to ultraviolet radiation. Pigment Cell Res 2007; 20: 2–13.
2 Hearing, VJ. Biogenesis of pigment granules: a sensitive way to regulate melanocyte function. J Dermatol Sci 2005; 37: 3–14.
3 Lang, D, Lu, MM, Huang, L, Engleka, KA, Zhang, M, et al.
Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature 2005; 433: 884–887.
4 Nishimura, EK, Granter, SR, Fisher, DE. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science 2005; 307: 720–724.
5 Osawa, M, Egawa, G, Mak, SS, Moriyama, M, Freter, R, et al.
Molecular characterization of melanocyte stem cells in their niche. Development 2005; 132: 5589–5599.
6 Oetting, WS, King, RA. Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism. Hum Mutat 1999; 13: 99–115.
7 Thomas, I, Kihiczak, GG, Fox, MD, Janniger, CK, Schwartz, RA. Piebaldism: an update. Int J Dermatol 2004; 43: 716–719.
8 Tachibana, M, Kobayashi, Y, Matsushima, Y. Mouse models for four types of Waardenburg syndrome. Pigment Cell Res 2003; 16: 448–454.
9 Smith, SD, Kelley, PM, Kenyon, JB, Hoover, D. Tietz syndrome (hypopigmentation/deafness) caused by mutation of MITF. J Med Genet 2000; 37: 446–448.
10 Shiflett, SL, Kaplan, J, Ward, DM. Chediak‐Higashi Syndrome: a rare disorder of lysosomes and lysosome related organelles. Pigment Cell Res 2002; 15: 251–257.
11 Wei, ML. Hermansky‐Pudlak syndrome: a disease of protein trafficking and organelle function. Pigment Cell Res 2006; 19: 19–42.
12 Chin, L, Garraway, LA, Fisher, DE. Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev 2006; 20: 2149–2182.
13 Klauschen, F, Angermann, BR, Meier‐Schellersheim, M. Understanding diseases by mouse click: the promise and potential of computational approaches in systems biology. Clin Exp Immunol 2007; 149: 424–429.
14 Sorger, PK. A reductionist`s systems biology: opinion. Curr Opin Cell Biol 2005; 17: 9–11.
15 Castle, WE, Allen, G. The heredity of albinism. Proc Am Acad Arts Sci 1903; 38: 603–621.
16 Haldane, JBS, Sprunt, AD, Haldane, NM. Reduplication in mice. J Genet 1915; 5: 133–135.
17 Silvers, WK. The Coat Colors of Mice: A Model for Mammalian Gene Action and Interaction
. New York: Springer Verlag
18 Dunn, LC, Charles, DR. Studies on spotting patterns I. Analysis of quantitative variations in the pied spotting of the house mouse. Genetics 1937; 22: 14–42.
19 Bennett, DC, Lamoreux, ML. The color loci of mice—genetic century. Pigment Cell Res 2003; 16: 333–344.
20 Oetting, WS, Montoliu, L, Bennett, DC; European Society for Pigment Cell Research. Color Genes
. 2008; .
21 Barsh, GS. The genetics of pigmentation: from fancy genes to complex traits. Trends Genet 1996; 12: 299–305.
22 Jackson, IJ. Homologous pigmentation mutations in human, mouse and other model organisms. Hum Mol Genet 1997; 6: 1613–1624.
23 Baxter, LL, Pavan, WJ. The oculocutaneous albinism type IV gene Matp is a new marker of pigment cell precursors during mouse embryonic development. Mech Dev 2002; 116: 209–212.
24 Baxter, LL, Pavan, WJ. Pmel17 expression is Mitf‐dependent and reveals cranial melanoblast migration during murine development. Gene Expr Patterns 2003; 3: 703–707.
25 Bentley, NJ, Eisen, T, Goding, CR. Melanocyte‐specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator. Mol Cell Biol 1994; 14: 7996–8006.
26 Du, J, Fisher, DE. Identification of Aim‐1 as the underwhite mouse mutant and its transcriptional regulation by MITF. J Biol Chem 2002; 277: 402–406.
27 Aoki, H, Moro, O. Involvement of microphthalmia‐associated transcription factor (MITF) in expression of human melanocortin‐1 receptor (MC1R). Life Sci 2002; 71: 2171–2179.
28 Hodgkinson, CA, Moore, KJ, Nakayama, A, Steingrimsson, E, Copeland, NG, et al.
Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic‐helix‐loop‐helix‐zipper protein. Cell 1993; 74: 395–404.
29 Hughes, MJ, Lingrel, JB, Krakowsky, JM, Anderson, KP. A helix‐loop‐helix transcription factor‐like gene is located at the mi locus. J Biol Chem 1993; 268: 20687–20690.
30 Tachibana, M, Takeda, K, Nobukuni, Y, Urabe, K, Long, JE, et al.
Ectopic expression of MITF, a gene for Waardenburg syndrome type 2, converts fibroblasts to cells with melanocyte characteristics. Nat Genet 1996; 14: 50–54.
31 Yasumoto, K, Yokoyama, K, Takahashi, K, Tomita, Y, Shibahara, S. Functional analysis of microphthalmia‐associated transcription factor in pigment cell‐specific transcription of the human tyrosinase family genes. J Biol Chem 1997; 272: 503–509.
32 Yokoyama, K, Yasumoto, K, Suzuki, H, Shibahara, S. Cloning of the human DOPAchrome tautomerase/tyrosinase‐related protein 2 gene and identification of two regulatory regions required for its pigment cell‐specific expression. J Biol Chem 1994; 269: 27080–27087.
33 Sato‐Jin, K, Nishimura, EK, Akasaka, E, Huber, W, Nakano, H, et al.
Epistatic connections between microphthalmia‐associated transcription factor and endothelin signaling in Waardenburg syndrome and other pigmentary disorders. FASEB J 2008; 22: 1155–1168.
34 Buscà, R, Berra, E, Gaggioli, C, Khaled, M, Bille, K, et al.
Hypoxia‐inducible factor 1 − α is a new target of microphthalmia‐associated transcription factor (MITF) in melanoma cells. J Cell Biol 2005; 170: 49–59.
35 McGill, GG, Horstmann, M, Widlund, HR, Du, J, Motyckova, G, et al.
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 2002; 109: 707–718.
36 McGill, GG, Haq, R, Nishimura, EK, Fisher, DE. c‐Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem 2006; 281: 10365–10373.
37 Carreira, S, Goodall, J, Aksan, I, La Rocca, SA, Galibert, MD, et al.
Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature 2005; 433: 764–769.
38 Carreira, S, Liu, B, Goding, CR. The gene encoding the T‐box factor Tbx2 is a target for the microphthalmia‐associated transcription factor in melanocytes. J Biol Chem 2000; 275: 21920–21927.
39 Du, J, Widlund, HR, Horstmann, MA, Ramaswamy, S, Ross, K, et al.
Critical role of CDK2 for melanoma growth linked to its melanocyte‐specific transcriptional regulation by MITF. Cancer Cell 2004; 6: 565–576.
40 Hemesath, TJ, Price, ER, Takemoto, C, Badalian, T, Fisher, DE. MAP kinase links the transcription factor Microphthalmia to c‐Kit signalling in melanocytes. Nature 1998; 391: 298–301.
41 Larribere, L, Hilmi, C, Khaled, M, Gaggioli, C, Bille, K, et al.
The cleavage of microphthalmia‐associated transcription factor, MITF, by caspases plays an essential role in melanocyte and melanoma cell apoptosis. Genes Dev 2005; 19: 1980–1985.
42 Miller, AJ, Levy, C, Davis, IJ, Razin, E, Fisher, DE. Sumoylation of MITF and its related family members TFE3 and TFEB. J Biol Chem 2005; 280: 146–155.
43 Murakami, H, Arnheiter, H. Sumoylation modulates transcriptional activity of MITF in a promoter‐specific manner. Pigment Cell Res 2005; 18: 265–277.
44 Wu, M, Hemesath, TJ, Takemoto, CM, Horstmann, MA, Wells, AG, et al.
c‐Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes Dev 2000; 14: 301–312.
45 Xu, W, Gong, L, Haddad, MM, Bischof, O, Campisi, J, et al.
Regulation of microphthalmia‐associated transcription factor MITF protein levels by association with the ubiquitin‐conjugating enzyme hUBC9. Exp Cell Res 2000; 255: 135–143.
46 Margue, CM, Bernasconi, M, Barr, FG, Schafer, BW. Transcriptional modulation of the anti‐apoptotic protein BCL‐XL by the paired box transcription factors PAX3 and PAX3/FKHR. Oncogene 2000; 19: 2921–2929.
47 Pani, L, Horal, M, Loeken, MR. Rescue of neural tube defects in Pax‐3‐deficient embryos by p53 loss of function: implications for Pax‐3‐dependent development and tumorigenesis. Genes Dev 2002; 16: 676–680.
48 Underwood, TJ, Amin, J, Lillycrop, KA, Blaydes, JP. Dissection of the functional interaction between p53 and the embryonic proto‐oncoprotein PAX3. FEBS Lett 2007; 581: 5831–5835.
49 He, SJ, Stevens, G, Braithwaite, AW, Eccles, MR. Transfection of melanoma cells with antisense PAX3 oligonucleotides additively complements cisplatin‐induced cytotoxicity. Mol Cancer Ther 2005; 4: 996–1003.
50 Muratovska, A, Zhou, C, He, S, Goodyer, P, Eccles, MR. Paired‐Box genes are frequently expressed in cancer and often required for cancer cell survival. Oncogene 2003; 22: 7989–7997.
51 Bondurand, N, Pingault, V, Goerich, DE, Lemort, N, Sock, E, et al.
Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome. Hum Mol Genet 2000; 9: 1907–1917.
52 Potterf, SB, Furumura, M, Dunn, KJ, Arnheiter, H, Pavan, WJ. Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3. Hum Genet 2000; 107: 1–6.
53 Watanabe, A, Takeda, K, Ploplis, B, Tachibana, M. Epistatic relationship between Waardenburg syndrome genes MITF and PAX3. Nat Genet 1998; 18: 283–286.
54 Mollaaghababa, R, Pavan, WJ. The importance of having your SOX on: role of SOX10 in the development of neural crest‐derived melanocytes and glia. Oncogene 2003; 22: 3024–3034.
55 Hou, L, Arnheiter, H, Pavan, WJ. Interspecies difference in the regulation of melanocyte development by SOX10 and MITF. Proc Natl Acad Sci U S A 2006; 103: 9081–9085.
56 Murisier, F, Guichard, S, Beermann, F. A conserved transcriptional enhancer that specifies Tyrp1 expression to melanocytes. Dev Biol 2006; 298: 644–655.
57 Murisier, F, Guichard, S, Beermann, F. The tyrosinase enhancer is activated by Sox10 and Mitf in mouse melanocytes. Pigment Cell Res 2007; 20: 173–184.
58 Potterf, SB, Mollaaghababa, R, Hou, L, Southard‐Smith, EM, Hornyak, TJ, et al.
Analysis of SOX10 function in neural crest‐derived melanocyte development: SOX10‐dependent transcriptional control of dopachrome tautomerase. Dev Biol 2001; 237: 245–257.
59 Cook, AL, Smith, AG, Smit, DJ, Leonard, JH, Sturm, RA. Co‐expression of SOX9 and SOX10 during melanocytic differentiation in vitro. Exp Cell Res 2005; 308: 222–235.
60 Hakami, RM, Hou, L, Baxter, LL, Loftus, SK, Southard‐Smith, EM, et al.
Genetic evidence does not support direct regulation of EDNRB by SOX10 in migratory neural crest and the melanocyte lineage. Mech Dev 2006; 123: 124–134.
61 Stanchina, L, Baral, V, Robert, F, Pingault, V, Lemort, N, et al.
Interactions between Sox10, Edn3 and Ednrb during enteric nervous system and melanocyte development. Dev Biol 2006; 295: 232–249.
62 Yokoyama, S, Takeda, K, Shibahara, S. SOX10, in combination with Sp1, regulates the endothelin receptor type B gene in human melanocyte lineage cells. FEBS J 2006; 273: 1805–1820.
63 Fitch, KR, McGowan, KA, Van Raamsdonk, CD, Fuchs, H, Lee, D, et al.
Genetics of dark skin in mice. Genes Dev 2003; 17: 214–228.
64 Kelsh, RN, Brand, M, Jiang, YJ, Heisenberg, CP, Lin, S, et al.
Zebrafish pigmentation mutations and the processes of neural crest development. Development 1996; 123: 369–389.
65 McGowan, KA, Aradhya, S, Fuchs, H, de Angelis, MH, Barsh, GS. A mouse keratin 1 mutation causes dark skin and epidermolytic hyperkeratosis. J Invest Dermatol 2006; 126: 1013–1016.
66 McGowan, KA, Li, JZ, Park, CY, Beaudry, V, Tabor, HK, et al.
Ribosomal mutations cause p53‐mediated dark skin and pleiotropic effects. Nat Genet 2008; 40: 963–970.
67 Rawls, JF, Frieda, MR, McAdow, AR, Gross, JP, Clayton, CM, et al.
Coupled mutagenesis screens and genetic mapping in zebrafish. Genetics 2003; 163: 997–1009.
68 Van Raamsdonk, CD, Fitch, KR, Fuchs, H, de Angelis, MH, Barsh, GS. Effects of G‐protein mutations on skin color. Nat Genet 2004; 36: 961–968.
69 Bogani, D, Warr, N, Elms, P, Davies, J, Tymowska‐Lalanne, Z, et al.
New semidominant mutations that affect mouse development. Genesis 2004; 40: 109–117.
70 Buac, K, Watkins‐Chow, DE, Loftus, SK, Larson, DM, Incao, A, et al.
A Sox10 expression screen identifies an amino acid essential for Erbb3 function. PLoS Genet 2008; 4: e1000177.
71 Matera, I, Cockroft, JL, Moran, JL, Beier, DR, Goldowitz, D, et al.
A mouse model of Waardenburg syndrome type IV resulting from an ENU‐induced mutation in endothelin 3. Pigment Cell Res 2007; 20: 210–215.
72 Matera, I, Watkins‐Chow, DE, Loftus, SK, Hou, L, Incao, A, et al.
A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. Hum Mol Genet 2008; 17: 2118–2131.
73 Ganesan, AK, Ho, H, Bodemann, B, Petersen, S, Aruri, J, et al.
Genome‐wide siRNA‐based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. PLoS Genet 2008; 4: e1000298.
74 Gobeil, S, Zhu, X, Doillon, CJ, Green, MR. A genome‐wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene. Genes Dev 2008; 22: 2932–2940.
75 Brown, SD, Hardisty, RE. Mutagenesis strategies for identifying novel loci associated with disease phenotypes. Semin Cell Dev Biol 2003; 14: 19–24.
76 Echeverri, CJ, Beachy, PA, Baum, B, Boutros, M, Buchholz, F, et al.
Minimizing the risk of reporting false positives in large‐scale RNAi screens. Nat Methods 2006; 3: 777–779.
77 Haney, SA. Increasing the robustness and validity of RNAi screens. Pharmacogenomics 2007; 8: 1037–1049.
78 Chi, A, Valencia, JC, Hu, ZZ, Watabe, H, Yamaguchi, H, et al.
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. J Proteome Res 2006; 5: 3135–3144.
79 Hu, ZZ, Valencia, J, Huang, H, Chi, A, Shabanowitz, J, et al.
Comparative bioinformatics analyses and profiling of lysosome‐related organelle proteomes. Int J Mass Spectrom 2007; 259: 147–160.
80 Kushimoto, T, Basrur, V, Valencia, J, Matsunaga, J, Vieira, WD, et al.
A model for melanosome biogenesis based on the purification and analysis of early melanosomes. Proc Natl Acad Sci USA 2001; 98: 10698–10703.
81 Rendl, M, Lewis, L, Fuchs, E. Molecular dissection of mesenchymal‐epithelial interactions in the hair follicle. PLoS Biol 2005; 3: e331.
82 April, CS, Barsh, GS. Skin layer‐specific transcriptional profiles in normal and recessive yellow (Mc1re/Mc1re) mice. Pigment Cell Res 2006; 19: 194–205.
83 Hoek, KS, Schlegel, NC, Eichhoff, OM, Widmer, DS, Praetorius, C, et al.
Novel MITF targets identified using a two‐step DNA microarray strategy. Pigment Cell Melanoma Res 2008; 21: 665–676.
84 Loftus, SK, Antonellis, A, Matera, I, Renaud, G, Baxter, LL, et al.
Gpnmb is a melanoblast‐expressed, MITF‐dependent gene. Pigment Cell Melanoma Res 2009; 22: 99–110.
85 Mardis, E. The impact of next‐generation sequencing technology on genetics. Trends Genet 2008; 24: 133–141.
86 Cordero, F, Botta, M, Calogero, RA. Microarray data analysis and mining approaches. Brief Funct Genomic Proteomic 2007; 6: 265–281.
87 Wilkes, T, Laux, H, Foy, CA. Microarray data quality—review of current developments. OMICS 2007; 11: 1–13.
88 Carninci, P, Kasukawa, T, Katayama, S, et al.
, Consortium RGERGaGSGGNPC Group. The transcriptional landscape of the mammalian genome. Science 2005; 309(()
89 Goding, CR. Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage. Genes Dev 2000; 14: 1712–1728.
90 Birney, E, Stamatoyannopoulos, JA, Dutta, A, Guigo, R, Gingeras, TR, et al.
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 2007; 447: 799–816.
91 Antonellis, A, Bennett, WR, Menheniott, TR, Prasad, AB, Lee‐Lin, SQ, et al.
Deletion of long‐range sequences at Sox10 compromises developmental expression in a mouse model of Waardenburg‐Shah (WS4) syndrome. Hum Mol Genet 2006; 15: 259–271.
92 Antonellis, A, Huynh, JL, Lee‐Lin, SQ, Vinton, RM, Renaud, G, et al.
Identification of neural crest and glial enhancers at the mouse Sox10 locus through transgenesis in zebrafish. PLoS Genet 2008; 4: e1000174.
93 Werner, T, Hammer, A, Wahlbuhl, M, Bösl, MR, Wegner, M. Multiple conserved regulatory elements with overlapping functions determine Sox10 expression in mouse embryogenesis. Nucleic Acids Res 2007; 35: 6526–6538.
94 Barski, A, Cuddapah, S, Cui, K, Roh, TY, Schones, DE, et al.
High‐resolution profiling of histone methylations in the human genome. Cell 2007; 129: 823–837.
95 Abdel‐Malek, ZA, Knittel, J, Kadekaro, AL, Swope, VB, Starner, R. The melanocortin 1 receptor and the UV response of human melanocytes—a shift in paradigm. Photochem Photobiol 2008; 84: 501–508.
96 Jean, S, Bideau, C, Bellon, L, Halimi, G, De Méo, M, et al.
The expression of genes induced in melanocytes by exposure to 365‐nm UVA: study by cDNA arrays and real‐time quantitative RT‐PCR. Biochim Biophys Acta 2001; 1522: 89–96.
97 Valéry, C, Grob, JJ, Verrando, P. Identification by cDNA microarray technology of genes modulated by artificial ultraviolet radiation in normal human melanocytes: relation to melanocarcinogenesis. J Invest Dermatol 2001; 117: 1471–1482.
98 Yang, G, Zhang, G, Pittelkow, MR, Ramoni, M, Tsao, H. Expression profiling of UVB response in melanocytes identifies a set of p53‐target genes. J Invest Dermatol 2006; 126: 2490–2506.
99 Bittner, M, Meltzer, P, Chen, Y, Jiang, Y, Seftor, E, et al.
Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 2000; 406: 536–540.
100 Fecher, LA, Cummings, SD, Keefe, MJ, Alani, RM. Toward a molecular classification of melanoma. J Clin Oncol 2007; 25: 1606–1620.
101 Hoek, KS, Schlegel, NC, Brafford, P, Sucker, A, Ugurel, S, et al.
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature. Pigment Cell Res 2006; 19: 290–302.
102 Ryu, B, Kim, DS, Deluca, AM, Alani, RM. Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. PLoS ONE 2007; 2: e594.
103 Bauer, J, Bastian, BC. Distinguishing melanocytic nevi from melanoma by DNA copy number changes: comparative genomic hybridization as a research and diagnostic tool. Dermatol Ther 2006; 19: 40–49.
104 Lin, WM, Baker, AC, Beroukhim, R, Winckler, W, Feng, W, et al.
Modeling genomic diversity and tumor dependency in malignant melanoma. Cancer Res 2008; 68: 664–673.
105 Dissanayake, SK, Wade, M, Johnson, CE, O`Connell, MP, Leotlela, PD, et al.
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem 2007; 282: 17259–17271.
106 Weeraratna, AT, Jiang, Y, Hostetter, G, Rosenblatt, K, Duray, P, et al.
Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 2002; 1: 279–288.
107 Loftus, SK, Larson, DM, Baxter, LL, Antonellis, A, Chen, Y, et al.
Mutation of melanosome protein RAB38 in chocolate mice. Proc Natl Acad Sci U S A 2002; 99: 4471–4476.
108 Johansson, P, Pavey, S, Hayward, N. Confirmation of a BRAF mutation‐associated gene expression signature in melanoma. Pigment Cell Res 2007; 20: 216–221.
109 Magnoni, C, Tenedini, E, Ferrari, F, Benassi, L, Bernardi, C, et al.
Transcriptional profiles in melanocytes from clinically unaffected skin distinguish the neoplastic growth pattern in patients with melanoma. Br J Dermatol 2007; 156: 62–71.
110 Wagner, KW, Punnoose, EA, Januario, T, Lawrence, DA, Pitti, RM, et al.
Death‐receptor O‐glycosylation controls tumor‐cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat Med 2007; 13: 1070–1077.
111 Ren, S, Liu, S, Howell, P, Xi, Y, Enkemann, SA, et al.
The impact of genomics in understanding human melanoma progression and metastasis. Cancer Control 2008; 15: 202–215.
112 Baxter, LL, Hsu, BJ, Umayam, L, Wolfsberg, TG, Larson, DM, et al.
Informatic and genomic analysis of melanocyte cDNA libraries as a resource for the study of melanocyte development and function. Pigment Cell Res 2007; 20: 201–209.
113 Carninci, P, Waki, K, Shiraki, T, Konno, H, Shibata, K, et al.
Targeting a complex transcriptome: the construction of the mouse full‐length cDNA encyclopedia. Genome Res 2003; 13: 1273–1289.
114 Ben‐Tabou de‐Leon, S, Davidson, EH. Modeling the dynamics of transcriptional gene regulatory networks for animal development. Dev Biol 2009; 325: 317–328.
115 Cohen, AA, Geva‐Zatorsky, N, Eden, E, Frenkel‐Morgenstern, M, Issaeva, I, et al.
Dynamic proteomics of individual cancer cells in response to a drug. Science 2008; 322: 1511–1516.
116 Ohyabu, Y, Kaul, Z, Yoshioka, T, Inoue, K, Sakai, S, et al.
Stable and non‐disruptive in vitro/in vivo labeling of mesenchymal stem cells by internalizing quantum dots. Hum Gene Ther 2009; 20: 219–226.
117 Ram, S, Prabhat, P, Chao, J, Ward, ES, Ober, RJ. High accuracy 3D quantum dot tracking with multifocal plane microscopy for the study of fast intracellular dynamics in live cells. Biophys J 2008; 95: 6025–6043.
118 Urano, Y, Asanuma, D, Hama, Y, Koyama, Y, Barrett, T, et al.
Selective molecular imaging of viable cancer cells with pH‐activatable fluorescence probes. Nat Med 2009; 15: 104–109.
119 Murray, JI, Bao, Z, Boyle, TJ, Boeck, ME, Mericle, BL, et al.
Automated analysis of embryonic gene expression with cellular resolution in C. elegans
. Nat Methods 2008; 5: 703–709.