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WIREs Syst Biol Med
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Systems Biology and Physiome Projects

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Abstract This article is categorized under: Physiology > Mammalian Physiology in Health and Disease

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Relationships between systems approaches in biology, physiology, and medicine and experimental data at different levels of biological organization.

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The major components involved in linking signaling pathways at the cell level to continuum mechanics at the tissue level. Large deformation soft tissue mechanics is used to solve for the shape of the aneurysm. 3D CFD within this arterial volume then gives pressure and shear stress acting on the endothelial cells lining the arterial wall. The endothelial cells respond via signaling pathways that communicate with the smooth muscle cells and fibroblasts to remodel the matrix of collagen and elastin that determines the mechanical properties of the tissue. The blood vessel wall is constantly adapting to the mechanical loads. The purpose of coupling these processes together is to better understand the factors that lead to cerebral aneurysms.

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