References 1 Jobson, RW, Qiu, YL. Did RNA editing in plant organellar genomes originate under natural selection or through genetic drift? Biol Direct 2008, 3: 43. 2 Maas, S, Rich, A. Changing genetic information through RNA editing. Bioessays 2000, 22: 790–802. 3 Blanc, V, Davidson, NO. C‐to‐U RNA editing: mechanisms leading to genetic diversity. J Biol Chem 2003, 278: 1395–1398. 4 Wedekind, JE, Dance, GS, Sowden, MP, Smith, HC. Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business. Trends Genet 2003, 19: 207–216. 5 Teng, B, Burant, CF, Davidson, NO. Molecular cloning of an apolipoprotein B messenger RNA editing protein. Science (New York, NY) 1993, 260: 1816–1819. 6 Conticello, SG. The AID/APOBEC family of nucleic acid mutators. Genome Biol 2008, 9: 229. 7 Davidson, NO, Shelness, GS. APOLIPOPROTEIN B: mRNA editing, lipoprotein assembly, and presecretory degradation. Annu Rev Nutr 2000, 20: 169–193. 8 Shah, RR, Knott, TJ, Legros, JE, Navaratnam, N, Greeve, JC, et al. Sequence requirements for the editing of apolipoprotein B mRNA. J Biol Chem 1991, 266: 16301–16304. 9 Backus, JW, Smith, HC. Three distinct RNA sequence elements are required for efficient apolipoprotein B (apoB) RNA editing in vitro. Nucleic Acids Res 1992, 20: 6007–6014. 10 Maris, C, Masse, J, Chester, A, Navaratnam, N, Allain, FH. NMR structure of the apoB mRNA stem‐loop and its interaction with the C to U editing APOBEC1 complementary factor. RNA (New York, NY) 2005, 11: 173–186. 11 Hersberger, M, Patarroyo‐White, S, Arnold, KS, Innerarity, TL. Phylogenetic analysis of the apolipoprotein B mRNA‐editing region. Evidence for a secondary structure between the mooring sequence and the 3′ efficiency element. J Biol Chem 1999, 274: 34590–34597. 12 Richardson, N, Navaratnam, N, Scott, J. Secondary structure for the apolipoprotein B mRNA editing site. AU‐binding proteins interact with s stem loop. J Biol Chem 1998, 274: 31707–31717. 13 Lellek, H, Kirsten, R, Diehl, I, Apostel, F, Buck, F, et al. Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme‐complex. J Biol Chem 2000, 275: 19848–19856. 14 Mehta, A, Kinter, MT, Sherman, NE, Driscoll, DM. Molecular cloning of apobec‐1 complementation factor, a novel RNA‐binding protein involved in the editing of apolipoprotein B mRNA. Mol Cell Biol 2000, 20: 1846–1854. 15 Nakamuta, M, Chang, BH, Zsigmond, E, Kobayashi, K, Lei, H, et al. Complete phenotypic characterization of apobec‐1 knockout mice with a wild‐type genetic background and a human apolipoprotein B transgenic background, and restoration of apolipoprotein B mRNA editing by somatic gene transfer of Apobec‐1. J Biol Chem 1996, 271: 25981–25988. 16 Morrison, JR, Paszty, C, Stevens, ME, Hughes, SD, Forte, T, et al. Apolipoprotein B RNA editing enzyme‐deficient mice are viable despite alterations in lipoprotein metabolism. Proc Natl Acad Sci USA 1996, 93: 7154–7159. 17 Hirano, K, Young, SG, Farese, RV Jr , Ng, J, Sande, E, et al. Targeted disruption of the mouse apobec‐1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48. J Biol Chem 1996, 271: 9887–9890. 18 Cho, SJ, Blanc, V, Davidson, NO. Mouse models as tools to explore C to U RNA editing. Methods Enzymol 2007, 424: 417–435. 19 Giannoni, F, Bonen, DK, Funahashi, T, Hadjiagapiou, C, Burant, CF, et al. Complementation of apolipoprotein B mRNA editing by human liver accompanied by secretion of apolipoprotein B48. J Biol Chem 1994, 269: 5932–5936. 20 Teng, B, Verp, M, Salomon, J, Davidson, NO. Apolipoprotein B messenger RNA editing is developmentally regulated and widely expressed in human tissues. J Biol Chem 1990, 265: 20616–20620. 21 Hadjiagapiou, C, Giannoni, F, Funahashi, T, Skarosi, SF, Davidson, NO. Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein. Nucleic Acids Res 1994, 22: 1874–1879. 22 Chester, A, Somasekaram, A, Tzimina, M, Jarmuz, A, Gisbourne, J, et al. The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense‐mediated decay. EMBO J 2003, 22: 3971–3982. 23 Yang, Y, Sowden, MP, Yang, Y, Smith, HC. Intracellular trafficking determinants in APOBEC‐1, the catalytic subunit for cytidine to uridine editing of apolipoprotein B mRNA. Exp Cell Res 2001, 267(2 ): 153–164. 24 Sowden, M, Hamm, JK, Spinelli, S, Smith, HC. Determinants involved in regulating the proportion of edited apolipoprotein B RNAs. RNA (New York, NY) 1996, 2: 274–288. 25 Lau, PP, Xiong, WJ, Zhu, HJ, Chen, SH, Chan, L. Apolipoprotein B mRNA editing is an intranuclear event that occurs posttranscriptionally coincident with splicing and polyadenylation. J Biol Chem 1991, 266: 20550–20554. 26 Mukhopadhyay, D, Plateroti, M, Anant, S, Nassir, F, Samarut, J, et al. Thyroid hormone regulates hepatic triglyceride mobilization and apolipoprotein B messenger ribonucleic acid editing in a murine model of congenital hypothyroidism. Endocrinology 2003, 144: 711–719. 27 Sowden, MP, Lehmann, DM, Lin, X, Smith, CO, Smith, HC. Identification of novel alternative splice variants of APOBEC‐1 complementation factor with different capacities to support apolipoprotein B mRNA editing. J Biol Chem 2004, 279: 197–206. 28 Lehmann, DM, Galloway, CA, Sowden, MP, Smith, HC. Metabolic regulation of apoB mRNA editing is associated with phosphorylation of APOBEC‐1 complementation factor. Nucleic Acids Res 2006, 34: 3299–3308. 29 Teng, BB, Ochsner, S, Zhang, Q, Soman, KV, Lau, PP, et al. Mutational analysis of apolipoprotein B mRNA editing enzyme (APOBEC1). Structure‐function relationships of RNA editing and dimerization. J Lipid Res 1999, 40: 623–635. 30 Yang, Y, Yang, Y, Smith, HC. Multiple protein domains determine the cell type‐specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing. Proc Natl Acad Sci USA 1997, 94: 13075–13080. 31 Blanc, V, Henderson, JO, Kennedy, S, Davidson, NO. Mutagenesis of apobec‐1 complementation factor reveals distinct domains that modulate RNA binding, protein‐protein interaction with apobec‐1, and complementation of C to U RNA‐editing activity. J Biol Chem 2001, 276: 46386–46393. 32 Sowden, MP, Ballatori, N, Jensen, KL, Reed, LH, Smith, HC. The editosome for cytidine to uridine mRNA editing has a native complexity of 27S: identification of intracellular domains containing active and inactive editing factors. J Cell Sci 2002, 115(Pt 5 ): 1027–1039. 33 Harris, SG, Sabio, I, Mayer, E, Steinberg, MF, Backus, JW, et al. Extract‐specific heterogeneity in high‐order complexes containing apolipoprotein B mRNA editing activity and RNA‐binding proteins. J Biol Chem 1993, 268: 7382–7392. 34 Anant, S, Henderson, JO, Mukhopadhyay, D, Navaratnam, N, Kennedy, S, et al. Novel role for RNA‐binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec‐1 and ACF, the apobec‐1 complementation factor. J Biol Chem 2001, 276: 47338–47351. 35 Lau, PP, Chan, L. Involvement of a chaperone regulator, Bcl2‐associated athanogene‐4, in apolipoprotein B mRNA editing. J Biol Chem 2003, 278: 52988–52996. 36 Lau, PP, Villanueva, H, Kobayashi, K, Nakamuta, M, Chang, BH, et al. A DnaJ protein, apobec‐1‐binding protein‐2, modulates apolipoprotein B mRNA editing. J Biol Chem 2001, 276: 46445–46452. 37 Greeve, J, Lellek, H, Rautenberg, P, Greten, H. Inhibition of the apolipoprotein B mRNA editing enzyme‐complex by hnRNP C1 protein and 40S hnRNP complexes. Biol Chem 1998, 379: 1063–1073. 38 Anant, S, Blanc, V, Davidson, NO. Molecular regulation, evolutionary, and functional adaptations associated with C to U editing of mammalian apolipoproteinB mRNA. Prog Nucleic Acid Res Mol Biol 2003, 75: 1–41. 39 Blanc, V, Navaratnam, N, Henderson, JO, Anant, S, Kennedy, S, et al. Identification of GRY‐RBP as an apolipoprotein B RNA‐binding protein that interacts with both apobec‐1 and apobec‐1 complementation factor to modulate C to U editing. J Biol Chem 2001, 276: 10272–10283. 40 Chen, Z, Eggerman, TL, Patterson, AP. ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components. Am J Physiol 2007, 292: G53–G65. 41 Blanc, V, Henderson, JO, Newberry, EP, Kennedy, S, Luo, J, et al. Targeted deletion of the murine apobec‐1 complementation factor (acf) gene results in embryonic lethality. Mol Cell Biol 2005, 25: 7260–7269. 42 Skuse, GR, Cappione, AJ, Sowden, M, Metheny, LJ, Smith, HC. The neurofibromatosis type I messenger RNA undergoes base‐modification RNA editing. Nucleic Acids Res 1996, 24: 478–485. 43 Mukhopadhyay, D, Anant, S, Lee, RM, Kennedy, S, Viskochil, D, et al. C − %3E U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec‐1, the catalytic subunit of the apolipoprotein B mRNA‐editing enzyme. Am J Hum Genet 2002, 70: 38–50. 44 Anant, S, Davidson, NO. An AU‐rich sequence element (UUUN[A/U]U) downstream of the edited C in apolipoprotein B mRNA is a high‐affinity binding site for Apobec‐1: binding of Apobec‐1 to this motif in the 3′ untranslated region of c‐myc increases mRNA stability. Mol Cell Biol 2000, 20: 1982–1992. 45 Anant, S, Murmu, N, Houchen, CW, Mukhopadhyay, D, Riehl, TE, et al. Apobec‐1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase‐2 expression. Gastroenterology 2004, 127: 1139–1149. 46 Yamamoto, K, Arakawa, T, Ueda, N, Yamamoto, S. Transcriptional roles of nuclear factor kappa B and nuclear factor‐interleukin‐6 in the tumor necrosis factor alpha‐dependent induction of cyclooxygenase‐2 in MC3T3‐E1 cells. J Biol Chem 1995, 270: 31315–31320. 47 Strillacci, A, Griffoni, C, Sansone, P, Paterini, P, Piazzi, G, et al. MiR‐101 downregulation is involved in cyclooxygenase‐2 overexpression in human colon cancer cells. Exp Cell Res 2009, 315: 1439–1447. 48 Dixon, DA, Tolley, ND, King, PH, Nabors, LB, McIntyre, TM, et al. Altered expression of the mRNA stability factor HuR promotes cyclooxygenase‐2 expression in colon cancer cells. J Clin Invest 2001, 108: 1657–1665. 49 Blanc, V, Henderson, JO, Cho, S, Newberry, RD, Xie, Y, et al. Deletion of the AU‐rich RNA binding protein apobec‐1 reduces intestinal tumor burden in APCmin mice. Cancer Res 2007, 67: 8565–8573. 50 Tsujii, M, DuBois, RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 1995, 83: 493–501. 51 Eberhart, CE, Coffey, RJ, Radhika, A, Giardiello, FM, Ferrenbach, S, et al. Up‐regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 1994, 107: 1183–1188. 52 Powell‐Braxton, L, Veniant, M, Latvala, RD, Hirano, KI, Won, WB, et al. A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low‐fat chow diet. Nat Med 1998, 4: 934–938. 53 Xie, Y, Luo, J, Kennedy, S, Davidson, NO. Conditional intestinal lipotoxicity in Apobec‐1−/− Mttp‐IKO mice: a survival advantage for mammalian intestinal apolipoprotein B mRNA editing. J Biol Chem 2007, 282: 33043–33051. 54 Xie, Y, Blanc, V, Kerr, TA, Kennedy, S, Luo, J, et al. Decreased expression of cholesterol 7{alpha}‐hydroxylase and altered bile acid metabolism in Apobec‐1 − /− Mice lead to increased gallstone susceptibility. J Biol Chem 2009, 284: 16860–16871. 55 Chiang, JY. Bile acids: regulation of synthesis. J Lipid Res 2009, 50: 1955–1966. 56 Blow, MJ, Grocock, RJ, van Dongen, S, Enright, AJ, Dicks, E, et al. RNA editing of human microRNAs. Genome biol 2006, 7: R27. 57 Yang, W, Chendrimada, TP, Wang, Q, Higuchi, M, Seeburg, PH, et al. Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nat Struct Mol Biol 2006, 13: 13–21. 58 Teng, G, Hakimpour, P, Landgraf, P, Rice, A, Tuschl, T, et al. MicroRNA‐155 is a negative regulator of activation‐induced cytidine deaminase. Immunity 2008, 28: 621–629. 59 Yamanaka, S, Balestra, ME, Ferrell, LD, Fan, J, Arnold, KS, et al. Apolipoprotein B mRNA‐editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals. Proc Natl Acad Sci USA 1995, 92: 8483–8487. 60 Yamanaka, S, Poksay, KS, Driscoll, DM, Innerarity, TL. Hyperediting of multiple cytidines of apolipoprotein B mRNA by APOBEC‐1 requires auxiliary protein(s) but not a mooring sequence motif. J Biol Chem 1996, 271: 11506–11510. 61 Driscoll, DM, Lakhe‐Reddy, S, Oleksa, LM, Martinez, D. Induction of RNA editing at heterologous sites by sequences in apolipoprotein B mRNA. Mol Cell Biol 1993, 13: 7288–7294. 62 Sowden, M, Hamm, JK, Smith, HC. Overexpression of APOBEC‐1 results in mooring sequence‐dependent promiscuous RNA editing. J Biol Chem 1996, 271: 3011–3017. 63 Yamanaka, S, Poksay, KS, Arnold, KS, Innerarity, TL. A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA‐editing enzyme. Genes Dev 1997, 11: 321–333. 64 Yamanaka, S, Zhang, XY, Maeda, M, Miura, K, Wang, S, et al. Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway. EMBO J 2000, 19: 5533–5541. 65 Petersen‐Mahrt, SK, Neuberger, MS. In vitro deamination of cytosine to uracil in single‐stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1). J Biol Chem 2003, 278: 19583–19586. 66 Harris, RS, Liddament, MT. Retroviral restriction by APOBEC proteins. Nat Rev Immunol 2004, 4: 868–877. 67 Petersen‐Mahrt, SK, Coker, HA, Pauklin, S. DNA deaminases: AIDing hormones in immunity and cancer. J Mol Med 2009, 87: 893–897. 68 Rothstein, JL, Johnson, D, DeLoia, JA, Skowronski, J, Solter, D, et al. Gene expression during preimplantation mouse development. Genes Dev 1992, 6: 1190–1201. 69 Mukhopadhyay, D, Houchen, CW, Kennedy, S, Dieckgraefe, BK, Anant, S. Coupled mRNA stabilization and translational silencing of cyclooxygenase‐2 by a novel RNA binding protein, CUGBP2. Mol Cell 2003, 11: 113–126. 70 Sureban, SM, Murmu, N, Rodriguez, P, May, R, Maheshwari, R, et al. Functional antagonism between RNA binding proteins HuR and CUGBP2 determines the fate of COX‐2 mRNA translation. Gastroenterology 2007, 132: 1055–1065. 71 Yamasaki, S, Stoecklin, G, Kedersha, N, Simarro, M, Anderson, P. T‐cell intracellular antigen‐1 (TIA‐1)‐induced translational silencing promotes the decay of selected mRNAs. J Biol Chem 2007, 282: 30070–30077.