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Genomics: An Interdisciplinary View

This collection of articles on Genomics draws from multiple WIREs titles. Topics discussed include regulatory networks, posttranslational modifications, non-coding RNA, and functional genomics.

Genome‐wide DNA methylation profiling
Focus Article
WIREs Systems Biology and Medicine
Marina Bibikova,Jian‐Bing Fan
Published Online: Sep 29 2009
DOI: 10.1002/wsbm.35
Abstract Full article on Wiley Online Library:   HTML | PDF
Genome‐scale metabolic networks
Advanced Review
WIREs Systems Biology and Medicine
Marco Terzer,Nathaniel D. Maynard,Markus W. Covert,Jörg Stelling
Published Online: Jun 17 2009
DOI: 10.1002/wsbm.37
Abstract Full article on Wiley Online Library:   HTML | PDF
Genome‐wide maps of transcription regulatory elements
Advanced Review
WIREs Systems Biology and Medicine
Noboru J. Sakabe,Marcelo A. Nobrega
Published Online: Jan 27 2010
DOI: 10.1002/wsbm.70
Abstract Full article on Wiley Online Library:   HTML | PDF
Layers of epistasis: genome‐wide regulatory networks and network approaches to genome‐wide association studies
Advanced Review
WIREs Systems Biology and Medicine
Richard Cowper‐Sal·lari,Michael D. Cole,Margaret R. Karagas,Mathieu Lupien,Jason H. Moore
Published Online: Dec 31 2010
DOI: 10.1002/wsbm.132
Abstract Full article on Wiley Online Library:   HTML | PDF
Data mining of functional RNA structures in genomic sequences
Focus Article
WIREs Data Mining and Knowledge Discovery
Shu‐Yun Le,Bruce A. Shapiro
Published Online: Jan 10 2011
DOI: 10.1002/widm.13
Abstract Full article on Wiley Online Library:   HTML | PDF
Genome‐wide approaches in the study of microRNA biology
Advanced Review
WIREs Systems Biology and Medicine
Melissa L. Wilbert,Gene W. Yeo
Published Online: Dec 31 2010
DOI: 10.1002/wsbm.128
Abstract Full article on Wiley Online Library:   HTML | PDF
Protein microarrays for genome‐wide posttranslational modification analysis
Focus Article
WIREs Systems Biology and Medicine
Yifat Merbl,Marc W. Kirschner
Published Online: Sep 23 2010
DOI: 10.1002/wsbm.120
Abstract Full article on Wiley Online Library:   HTML | PDF
MicroRNA targeting in mammalian genomes: genes and mechanisms
Advanced Review
WIREs Systems Biology and Medicine
S. A. Muljo,C. Kanellopoulou,L. Aravind
Published Online: Aug 14 2009
DOI: 10.1002/wsbm.53
Abstract Full article on Wiley Online Library:   HTML | PDF
Role of the nuclear envelope in genome organization and gene expression
Advanced Review
WIREs Systems Biology and Medicine
David W. Van de Vosse,Yakun Wan,Richard W. Wozniak,John D. Aitchison
Published Online: Jul 20 2010
DOI: 10.1002/wsbm.101
Abstract Full article on Wiley Online Library:   HTML | PDF
Where gene discovery turns into systems biology: genome‐scale RNAi screens in Drosophila
Focus Article
WIREs Systems Biology and Medicine
Ralph A. Neumüller,Norbert Perrimon
Published Online: Dec 31 2010
DOI: 10.1002/wsbm.127
Abstract Full article on Wiley Online Library:   HTML | PDF
Functional genomics of the brain: uncovering networks in the CNS using a systems approach
Advanced Review
WIREs Systems Biology and Medicine
Genevieve Konopka
Published Online: Dec 31 2010
DOI: 10.1002/wsbm.139
Abstract Full article on Wiley Online Library:   HTML | PDF
DNA methylation and gene expression
Focus Article
WIREs Systems Biology and Medicine
Zahava Siegfried,Itamar Simon
Published Online: Oct 28 2009
DOI: 10.1002/wsbm.64
Abstract Full article on Wiley Online Library:   HTML | PDF
Evolution of transcriptional regulatory networks in yeast populations
Advanced Review
WIREs Systems Biology and Medicine
Duccio Cavalieri
Published Online: Dec 02 2009
DOI: 10.1002/wsbm.68
Abstract Full article on Wiley Online Library:   HTML | PDF
Postgenomic technologies targeting the Wnt signaling network
Advanced Review
WIREs Systems Biology and Medicine
Raluca Pancratov,Ramanuj DasGupta
Published Online: Mar 04 2011
DOI: 10.1002/wsbm.140
Abstract Full article on Wiley Online Library:   HTML | PDF
Nanogenomics in medicine
Advanced Review
WIREs Nanomedicine and Nanobiotechnology
Claudio Nicolini
Published Online: Nov 02 2009
DOI: 10.1002/wnan.64
Abstract Full article on Wiley Online Library:   HTML | PDF
Mediators and dynamics of DNA methylation
Advanced Review
WIREs Systems Biology and Medicine
Robert Shoemaker,Wei Wang,Kun Zhang
Published Online: Sep 28 2010
DOI: 10.1002/wsbm.124
Abstract Full article on Wiley Online Library:   HTML | PDF
Circuitry of mRNA regulation
Focus Article
WIREs Systems Biology and Medicine
Alexander Kanitz,André P. Gerber
Published Online: Sep 30 2009
DOI: 10.1002/wsbm.55
Abstract Full article on Wiley Online Library:   HTML | PDF
DNA rearrangements directed by non‐coding RNAs in ciliates
Advanced Review
WIREs RNA
Kazufumi Mochizuki
Published Online: Jul 15 2010
DOI: 10.1002/wrna.34
Abstract Full article on Wiley Online Library:   HTML | PDF
Pharmacogenomics: a systems approach
Overview
WIREs Systems Biology and Medicine
Liewei Wang
Published Online: Jul 23 2009
DOI: 10.1002/wsbm.42
Abstract Full article on Wiley Online Library:   HTML | PDF
DNA methylation alterations in multiple myeloma as a model for epigenetic changes in cancer
Advanced Review
WIREs Systems Biology and Medicine
Amy Sharma,Christoph J. Heuck,Melissa J. Fazzari,Jayesh Mehta,Seema Singhal,John M. Greally,Amit Verma
Published Online: Mar 24 2010
DOI: 10.1002/wsbm.89
Abstract Full article on Wiley Online Library:   HTML | PDF
Emerging clinical applications in cardiovascular pharmacogenomics
Advanced Review
WIREs Systems Biology and Medicine
Samir B. Damani,Eric J. Topol
Published Online: Aug 20 2010
DOI: 10.1002/wsbm.113
Abstract Full article on Wiley Online Library:   HTML | PDF
Advances in analysis of transcriptional regulatory networks
Advanced Review
WIREs Systems Biology and Medicine
Tae‐Min Kim,Peter J. Park
Published Online: Jul 08 2010
DOI: 10.1002/wsbm.105
Abstract Full article on Wiley Online Library:   HTML | PDF
Computational chemogenomics
Overview
WIREs Computational Molecular Science
Edgar Jacoby
Published Online: Jan 21 2011
DOI: 10.1002/wcms.11
Abstract Full article on Wiley Online Library:   HTML | PDF
Mechanisms of genetic regulation in gene expression: examples from drug metabolizing enzymes and transporters
Advanced Review
WIREs Systems Biology and Medicine
Dylan M. Glubb,Federico Innocenti
Published Online: Sep 23 2010
DOI: 10.1002/wsbm.125
Abstract Full article on Wiley Online Library:   HTML | PDF
Noncoding RNAs in gene regulation
Focus Article
WIREs Systems Biology and Medicine
Maxime Wery,Marta Kwapisz,Antonin Morillon
Published Online: Mar 04 2011
DOI: 10.1002/wsbm.148
Abstract Full article on Wiley Online Library:   HTML | PDF
Predictive data mining in clinical medicine: a focus on selected methods and applications
Advanced Review
WIREs Data Mining and Knowledge Discovery
Riccardo Bellazzi,Fulvia Ferrazzi,Lucia Sacchi
Published Online: Feb 11 2011
DOI: 10.1002/widm.23
Abstract Full article on Wiley Online Library:   HTML | PDF
Experimentally based sea urchin gene regulatory network and the causal explanation of developmental phenomenology
Focus Article
WIREs Systems Biology and Medicine
Smadar Ben‐Tabou de‐Leon,Eric H. Davidson
Published Online: Apr 29 2009
DOI: 10.1002/wsbm.24
Abstract Full article on Wiley Online Library:   HTML | PDF
Gene networks for nitrogen sensing, signaling, and response in Arabidopsis thaliana
Focus Article
WIREs Systems Biology and Medicine
Elena A. Vidal,Karem P. Tamayo,Rodrigo A. Gutierrez
Published Online: Mar 24 2010
DOI: 10.1002/wsbm.87
Abstract Full article on Wiley Online Library:   HTML | PDF

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Dan Beard

Dan Beard

Dr. Beard is currently Professor of Physiology at the Medical College of Wisconsin. His research focuses on systems engineering approaches to understanding the operation of physiological systems in health and disease.

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