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WIREs Comput Mol Sci
Impact Factor: 9.041

Drug Discovery: An Interdisciplinary View

Drug discovery requires a multitude of steps, from identifying targets, to synthesis, screening, and efficacy testing. Multidisciplinary research is required for the discovery process, as highlighted by the recent review articles selected.

Understanding drug‐likeness
Advanced Review
WIREs Computational Molecular Science
Published Online: Apr 28 2011
DOI: 10.1002/wcms.52
Abstract Full article on Wiley Online Library:   HTML | PDF
Enabling future drug discovery by de novo design
Advanced Review
WIREs Computational Molecular Science
Published Online: Apr 25 2011
DOI: 10.1002/wcms.49
Abstract Full article on Wiley Online Library:   HTML | PDF
Calcium ion channels: challenges and successes in drug discovery
Focus Article
WIREs Membrane Transport and Signaling
Published Online: Nov 16 2012
DOI: 10.1002/wmts.71
Abstract Full article on Wiley Online Library:   HTML | PDF
Pharmacogenomics discovery and implementation in genome‐wide association studies era
Opinion
WIREs Systems Biology and Medicine
Published Online: Nov 27 2012
DOI: 10.1002/wsbm.1199
Abstract Full article on Wiley Online Library:   HTML | PDF
Druggability predictions: methods, limitations, and applications
Overview
WIREs Computational Molecular Science
Published Online: Nov 29 2012
DOI: 10.1002/wcms.1134
Abstract Full article on Wiley Online Library:   HTML | PDF
Algorithms for chemoinformatics
Overview
WIREs Computational Molecular Science
Published Online: Apr 14 2011
DOI: 10.1002/wcms.42
Abstract Full article on Wiley Online Library:   HTML | PDF
Diversity selection algorithms
Advanced Review
WIREs Computational Molecular Science
Published Online: Apr 14 2011
DOI: 10.1002/wcms.33
Abstract Full article on Wiley Online Library:   HTML | PDF
Chemoinformatics: a history
Overview
WIREs Computational Molecular Science
Published Online: Jan 21 2011
DOI: 10.1002/wcms.1
Abstract Full article on Wiley Online Library:   HTML | PDF
Next challenges in protein–protein docking: from proteome to interactome and beyond
Overview
WIREs Computational Molecular Science
Published Online: Sep 28 2011
DOI: 10.1002/wcms.91
Abstract Full article on Wiley Online Library:   HTML | PDF
Outstanding challenges in protein–ligand docking and structure‐based virtual screening
Advanced Review
WIREs Computational Molecular Science
Published Online: Mar 16 2011
DOI: 10.1002/wcms.18
Abstract Full article on Wiley Online Library:   HTML | PDF
Receptor flexibility in small‐molecule docking calculations
Advanced Review
WIREs Computational Molecular Science
Published Online: Mar 17 2011
DOI: 10.1002/wcms.29
Abstract Full article on Wiley Online Library:   HTML | PDF
Mining flexible‐receptor molecular docking data
Focus Article
WIREs Data Mining and Knowledge Discovery
Published Online: Aug 19 2011
DOI: 10.1002/widm.46
Abstract Full article on Wiley Online Library:   HTML | PDF
Prediction of protein binding sites and hot spots
Advanced Review
WIREs Computational Molecular Science
Published Online: May 03 2011
DOI: 10.1002/wcms.45
Abstract Full article on Wiley Online Library:   HTML | PDF
Calcium channels as therapeutic targets
Advanced Review
WIREs Membrane Transport and Signaling
Published Online: Jan 24 2012
DOI: 10.1002/wmts.38
Abstract Full article on Wiley Online Library:   HTML | PDF
Small molecule screening in zebrafish: swimming in potential drug therapies
Focus Article
WIREs Developmental Biology
Published Online: Feb 28 2012
DOI: 10.1002/wdev.37
Abstract Full article on Wiley Online Library:   HTML | PDF
Pharmacokinetics
Advanced Review
WIREs Computational Statistics
Published Online: Mar 08 2011
DOI: 10.1002/wics.153
Abstract Full article on Wiley Online Library:   HTML | PDF
Mining proteomic data for biomedical research
Advanced Review
WIREs Data Mining and Knowledge Discovery
Published Online: Aug 12 2011
DOI: 10.1002/widm.45
Abstract Full article on Wiley Online Library:   HTML | PDF
Mass spectrometry‐based proteomics: qualitative identification to activity‐based protein profiling
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Jan 09 2012
DOI: 10.1002/wsbm.166
Abstract Full article on Wiley Online Library:   HTML | PDF
Similarity‐based data mining in files of two‐dimensional chemical structures using fingerprint measures of molecular resemblance
Advanced Review
WIREs Data Mining and Knowledge Discovery
Published Online: Mar 24 2011
DOI: 10.1002/widm.26
Abstract Full article on Wiley Online Library:   HTML | PDF
RNA decay: a novel therapeutic target in bacteria
Focus Article
WIREs RNA
Published Online: Feb 28 2012
DOI: 10.1002/wrna.1110
Abstract Full article on Wiley Online Library:   HTML | PDF
Recent advances in stealth coating of nanoparticle drug delivery systems
Focus Article
WIREs Nanomedicine and Nanobiotechnology
Published Online: Jan 09 2012
DOI: 10.1002/wnan.1157
Abstract Full article on Wiley Online Library:   HTML | PDF
Nanotechnology in interventional cardiology
Focus Article
WIREs Nanomedicine and Nanobiotechnology
Published Online: Jul 11 2011
DOI: 10.1002/wnan.154
Abstract Full article on Wiley Online Library:   HTML | PDF

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