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Drug Discovery: An Interdisciplinary View

Drug discovery requires a multitude of steps, from identifying targets, to synthesis, screening, and efficacy testing. Multidisciplinary research is required for the discovery process, as highlighted by the articles selected.

Understanding drug‐likeness
Advanced Review
WIREs Computational Molecular Science
Oleg Ursu,Anwar Rayan,Amiram Goldblum,Tudor I. Oprea
Published Online: Apr 28 2011
DOI: 10.1002/wcms.52
Abstract Full article on Wiley Online Library:   HTML | PDF
Enabling future drug discovery by de novo design
Advanced Review
WIREs Computational Molecular Science
Markus Hartenfeller,Gisbert Schneider
Published Online: Apr 25 2011
DOI: 10.1002/wcms.49
Abstract Full article on Wiley Online Library:   HTML | PDF
Calcium ion channels: challenges and successes in drug discovery
Focus Article
WIREs Membrane Transport and Signaling
Stefan I. McDonough
Published Online: Nov 16 2012
DOI: 10.1002/wmts.71
Abstract Full article on Wiley Online Library:   HTML | PDF
Pharmacogenomics discovery and implementation in genome‐wide association studies era
Opinion
WIREs Systems Biology and Medicine
Xiuqin Ni,Wei Zhang,R. Stephanie Huang
Published Online: Nov 27 2012
DOI: 10.1002/wsbm.1199
Abstract Full article on Wiley Online Library:   HTML | PDF
Druggability predictions: methods, limitations, and applications
Overview
WIREs Computational Molecular Science
Xavier Barril
Published Online: Nov 29 2012
DOI: 10.1002/wcms.1134
Abstract Full article on Wiley Online Library:   HTML | PDF
Algorithms for chemoinformatics
Overview
WIREs Computational Molecular Science
Nathan Brown
Published Online: Apr 14 2011
DOI: 10.1002/wcms.42
Abstract Full article on Wiley Online Library:   HTML | PDF
Diversity selection algorithms
Advanced Review
WIREs Computational Molecular Science
Valerie J. Gillet
Published Online: Apr 14 2011
DOI: 10.1002/wcms.33
Abstract Full article on Wiley Online Library:   HTML | PDF
Systems approaches and algorithms for discovery of combinatorial therapies
Advanced Review
WIREs Systems Biology and Medicine
Jacob D. Feala,Jorge Cortes,Phillip M. Duxbury,Carlo Piermarocchi,Andrew D. McCulloch,Giovanni Paternostro
Published Online: Sep 01 2009
DOI: 10.1002/wsbm.51
Abstract Full article on Wiley Online Library:   HTML | PDF
Chemoinformatics: a history
Overview
WIREs Computational Molecular Science
Peter Willett
Published Online: Jan 21 2011
DOI: 10.1002/wcms.1
Abstract Full article on Wiley Online Library:   HTML | PDF
Next challenges in protein–protein docking: from proteome to interactome and beyond
Overview
WIREs Computational Molecular Science
Adrien S.J. Melquiond,Ezgi Karaca,Panagiotis L. Kastritis,Alexandre M.J.J. Bonvin
Published Online: Sep 28 2011
DOI: 10.1002/wcms.91
Abstract Full article on Wiley Online Library:   HTML | PDF
Outstanding challenges in protein–ligand docking and structure‐based virtual screening
Advanced Review
WIREs Computational Molecular Science
Bohdan Waszkowycz,David E. Clark,Emanuela Gancia
Published Online: Mar 16 2011
DOI: 10.1002/wcms.18
Abstract Full article on Wiley Online Library:   HTML | PDF
Receptor flexibility in small‐molecule docking calculations
Advanced Review
WIREs Computational Molecular Science
Daria B. Kokh,Rebecca C. Wade,Wolfgang Wenzel
Published Online: Mar 17 2011
DOI: 10.1002/wcms.29
Abstract Full article on Wiley Online Library:   HTML | PDF
Mining flexible‐receptor molecular docking data
Focus Article
WIREs Data Mining and Knowledge Discovery
Karina S. Machado,Ana T. Winck,Duncan D. Ruiz,Osmar Norberto de Souza
Published Online: Aug 19 2011
DOI: 10.1002/widm.46
Abstract Full article on Wiley Online Library:   HTML | PDF
Prediction of protein binding sites and hot spots
Advanced Review
WIREs Computational Molecular Science
Juan Fernández‐Recio
Published Online: May 03 2011
DOI: 10.1002/wcms.45
Abstract Full article on Wiley Online Library:   HTML | PDF
Calcium channels as therapeutic targets
Advanced Review
WIREs Membrane Transport and Signaling
Francesco Belardetti,Gerald W. Zamponi
Published Online: Jan 24 2012
DOI: 10.1002/wmts.38
Abstract Full article on Wiley Online Library:   HTML | PDF
Small molecule screening in zebrafish: swimming in potential drug therapies
Focus Article
WIREs Developmental Biology
Owen J. Tamplin,Richard M. White,Lili Jing,Charles K. Kaufman,Scott A. Lacadie,Pulin Li,Alison M. Taylor,Leonard I. Zon
Published Online: Feb 28 2012
DOI: 10.1002/wdev.37
Abstract Full article on Wiley Online Library:   HTML | PDF
Pharmacokinetics
Advanced Review
WIREs Computational Statistics
Peter L. Bonate
Published Online: Mar 08 2011
DOI: 10.1002/wics.153
Abstract Full article on Wiley Online Library:   HTML | PDF
Mining proteomic data for biomedical research
Advanced Review
WIREs Data Mining and Knowledge Discovery
Laura L. Elo,Benno Schwikowski
Published Online: Aug 12 2011
DOI: 10.1002/widm.45
Abstract Full article on Wiley Online Library:   HTML | PDF
Mass spectrometry‐based proteomics: qualitative identification to activity‐based protein profiling
Advanced Review
WIREs Systems Biology and Medicine
Job D. Cardoza,Jignesh R. Parikh,Scott B. Ficarro,Jarrod A. Marto
Published Online: Jan 09 2012
DOI: 10.1002/wsbm.166
Abstract Full article on Wiley Online Library:   HTML | PDF
Similarity‐based data mining in files of two‐dimensional chemical structures using fingerprint measures of molecular resemblance
Advanced Review
WIREs Data Mining and Knowledge Discovery
Peter Willett
Published Online: Mar 24 2011
DOI: 10.1002/widm.26
Abstract Full article on Wiley Online Library:   HTML | PDF
The network as the target
Opinion
WIREs Systems Biology and Medicine
Julie E. Baggs,Michael E. Hughes,John B. Hogenesch
Published Online: Sep 29 2009
DOI: 10.1002/wsbm.57
Abstract Full article on Wiley Online Library:   HTML | PDF
Antibiotics that target protein synthesis
Overview
WIREs RNA
Lisa S. McCoy,Yun Xie,Yitzhak Tor
Published Online: Nov 22 2010
DOI: 10.1002/wrna.60
Abstract Full article on Wiley Online Library:   HTML | PDF
RNA decay: a novel therapeutic target in bacteria
Focus Article
WIREs RNA
Tess M. Eidem,Christelle M. Roux,Paul M. Dunman
Published Online: Feb 28 2012
DOI: 10.1002/wrna.1110
Abstract Full article on Wiley Online Library:   HTML | PDF
The RNA capping machinery as an anti‐infective target
Focus Article
WIREs RNA
Moheshwarnath Issur,Frédéric Picard‐Jean,Martin Bisaillon
Published Online: Oct 25 2010
DOI: 10.1002/wrna.43
Abstract Full article on Wiley Online Library:   HTML | PDF
Recent advances in stealth coating of nanoparticle drug delivery systems
Focus Article
WIREs Nanomedicine and Nanobiotechnology
Zohreh Amoozgar,Yoon Yeo
Published Online: Jan 09 2012
DOI: 10.1002/wnan.1157
Abstract Full article on Wiley Online Library:   HTML | PDF
Nanotechnology in interventional cardiology
Focus Article
WIREs Nanomedicine and Nanobiotechnology
Tillmann Cyrus,Samuel A. Wickline,Gregory M. Lanza
Published Online: Jul 11 2011
DOI: 10.1002/wnan.154
Abstract Full article on Wiley Online Library:   HTML | PDF
Drug Discovery in Infectious Diseases Series

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