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WIREs Syst Biol Med
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Cancer: A Systems Approach

A collection of articles recently published in WIREs Systems Biology and Medicine on cancer research or related topics.

Genome network medicine: innovation to overcome huge challenges in cancer therapy
Focus Article
WIREs Systems Biology and Medicine
Published Online: Dec 06 2013
DOI: 10.1002/wsbm.1254
Abstract Full article on Wiley Online Library:   HTML | PDF
Axes of differentiation in breast cancer: untangling stemness, lineage identity, and the epithelial to mesenchymal transition
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Nov 08 2013
DOI: 10.1002/wsbm.1252
Abstract Full article on Wiley Online Library:   HTML | PDF
Genomics and epigenomics of colorectal cancer
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Jan 16 2013
DOI: 10.1002/wsbm.1206
Abstract Full article on Wiley Online Library:   HTML | PDF
Accelerating cancer systems biology research through Semantic Web technology
Overview
WIREs Systems Biology and Medicine
Published Online: Nov 27 2012
DOI: 10.1002/wsbm.1200
Abstract Full article on Wiley Online Library:   HTML | PDF
Integration of proteomics into systems biology of cancer
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Mar 08 2012
DOI: 10.1002/wsbm.1169
Abstract Full article on Wiley Online Library:   HTML | PDF
Regulatory variation: an emerging vantage point for cancer biology
Overview
WIREs Systems Biology and Medicine
Published Online: Nov 19 2013
DOI: 10.1002/wsbm.1250
Abstract Full article on Wiley Online Library:   HTML | PDF
Integrative physical oncology
Opinion
WIREs Systems Biology and Medicine
Published Online: Aug 18 2011
DOI: 10.1002/wsbm.158
Abstract Full article on Wiley Online Library:   HTML | PDF
Using a systems biology approach to understand and study the mechanisms of metastasis
Focus Article
WIREs Systems Biology and Medicine
Published Online: Jul 19 2013
DOI: 10.1002/wsbm.1237
Abstract Full article on Wiley Online Library:   HTML | PDF
Intercellular adhesion: mechanisms for growth and metastasis of epithelial cancers
Focus Article
WIREs Systems Biology and Medicine
Published Online: Sep 12 2011
DOI: 10.1002/wsbm.160
Abstract Full article on Wiley Online Library:   HTML | PDF
Mechanistic modeling to investigate signaling by oncogenic Ras mutants
Focus Article
WIREs Systems Biology and Medicine
Published Online: Jul 15 2011
DOI: 10.1002/wsbm.156
Abstract Full article on Wiley Online Library:   HTML | PDF
Normal morphogenesis of epithelial tissues and progression of epithelial tumors
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Sep 02 2011
DOI: 10.1002/wsbm.159
Abstract Full article on Wiley Online Library:   HTML | PDF
Riding the crest of the wave: parallels between the neural crest and cancer in epithelial‐to‐mesenchymal transition and migration
Focus Article
WIREs Systems Biology and Medicine
Published Online: Apr 10 2013
DOI: 10.1002/wsbm.1224
Abstract Full article on Wiley Online Library:   HTML | PDF

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In the Spotlight

Blanche Capel

Blanche Capel

earned her Ph.D. at the University of Pennsylvania and has been at Duke University since 1993. She earned her endowed professorship, the James B. Duke Professor of Cell Biology, for the meaningful discoveries she has made since her postdoctoral work in genetics at the National Institute for Medical Research in London. The broad goal of the research in Dr. Capel’s laboratory is to characterize the cellular and molecular basis of morphogenesis – how the body forms. She uses gonadal (gender/sex) development in the mouse as her model system and investigates a gene she helped discover, Sry, the male sex determining gene. Gonad development is unique in that a single rudimentary tissue can be induced to form one of two different organs, an ovary or testis, and she is learning all she can about this central mystery of biology.

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