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WIREs Syst Biol Med
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Cancer: A Systems Approach

A collection of articles recently published in WIREs Systems Biology and Medicine on cancer research or related topics.

Genome network medicine: innovation to overcome huge challenges in cancer therapy
Focus Article
WIREs Systems Biology and Medicine
Published Online: Dec 06 2013
DOI: 10.1002/wsbm.1254
Abstract Full article on Wiley Online Library:   HTML | PDF
Axes of differentiation in breast cancer: untangling stemness, lineage identity, and the epithelial to mesenchymal transition
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Nov 08 2013
DOI: 10.1002/wsbm.1252
Abstract Full article on Wiley Online Library:   HTML | PDF
Genomics and epigenomics of colorectal cancer
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Jan 16 2013
DOI: 10.1002/wsbm.1206
Abstract Full article on Wiley Online Library:   HTML | PDF
Accelerating cancer systems biology research through Semantic Web technology
Overview
WIREs Systems Biology and Medicine
Published Online: Nov 27 2012
DOI: 10.1002/wsbm.1200
Abstract Full article on Wiley Online Library:   HTML | PDF
Integration of proteomics into systems biology of cancer
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Mar 08 2012
DOI: 10.1002/wsbm.1169
Abstract Full article on Wiley Online Library:   HTML | PDF
Regulatory variation: an emerging vantage point for cancer biology
Overview
WIREs Systems Biology and Medicine
Published Online: Nov 19 2013
DOI: 10.1002/wsbm.1250
Abstract Full article on Wiley Online Library:   HTML | PDF
Integrative physical oncology
Opinion
WIREs Systems Biology and Medicine
Published Online: Aug 18 2011
DOI: 10.1002/wsbm.158
Abstract Full article on Wiley Online Library:   HTML | PDF
Using a systems biology approach to understand and study the mechanisms of metastasis
Focus Article
WIREs Systems Biology and Medicine
Published Online: Jul 19 2013
DOI: 10.1002/wsbm.1237
Abstract Full article on Wiley Online Library:   HTML | PDF
Intercellular adhesion: mechanisms for growth and metastasis of epithelial cancers
Focus Article
WIREs Systems Biology and Medicine
Published Online: Sep 12 2011
DOI: 10.1002/wsbm.160
Abstract Full article on Wiley Online Library:   HTML | PDF
Mechanistic modeling to investigate signaling by oncogenic Ras mutants
Focus Article
WIREs Systems Biology and Medicine
Published Online: Jul 15 2011
DOI: 10.1002/wsbm.156
Abstract Full article on Wiley Online Library:   HTML | PDF
Normal morphogenesis of epithelial tissues and progression of epithelial tumors
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Sep 02 2011
DOI: 10.1002/wsbm.159
Abstract Full article on Wiley Online Library:   HTML | PDF
Riding the crest of the wave: parallels between the neural crest and cancer in epithelial‐to‐mesenchymal transition and migration
Focus Article
WIREs Systems Biology and Medicine
Published Online: Apr 10 2013
DOI: 10.1002/wsbm.1224
Abstract Full article on Wiley Online Library:   HTML | PDF

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In the Spotlight

William J. Pavan

William J. Pavan

is interested in using genomic tools to understand how an embryo develops into a functioning organism. His group focuses on neural crest cells, a group of stem cells that differentiate into a wide variety of tissues in the bodys. Issues with the development of the neural crest cells can cause many diseases, ranging from Waardenburg syndrome to cleft lip and palate. Using genomic research tools, Dr. Pavan seeks to identify the genes necessary for normal neural crest cell development, specifically the ones which differentiate into melanocytes. At least 15 genes have been recognized as important in the development of neural crest cells, but there are likely hundreds of genes involved in total. Dr. Pavan’s lab often uses the models of neural crest cell disorders in mice in order to identify the genes needed for normal development. They then study how these genes function, and whether there are corresponding genes in humans that can cause human diseases.

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