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WIREs Syst Biol Med
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Stem Cells: A Systems Approach

This collection brings together a series of reviews that highlight many important aspects regarding systems analyses of stem cells.

Stem cell genome‐to‐systems biology
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Apr 11 2011
DOI: 10.1002/wsbm.151
Abstract Full article on Wiley Online Library:   HTML | PDF
Stem cell bioengineering at the interface of systems‐based models and high‐throughput platforms
Overview
WIREs Systems Biology and Medicine
Published Online: Aug 23 2012
DOI: 10.1002/wsbm.1189
Abstract Full article on Wiley Online Library:   HTML | PDF
The molecular circuitry underlying pluripotency in embryonic stem cells
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Jul 03 2012
DOI: 10.1002/wsbm.1182
Abstract Full article on Wiley Online Library:   HTML | PDF
Hematopoietic stem cell: self‐renewal versus differentiation
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Apr 01 2010
DOI: 10.1002/wsbm.86
Abstract Full article on Wiley Online Library:   HTML | PDF
Maintenance and differentiation of neural stem cells
Focus Article
WIREs Systems Biology and Medicine
Published Online: Jun 21 2010
DOI: 10.1002/wsbm.100
Abstract Full article on Wiley Online Library:   HTML | PDF
Biophysics and dynamics of natural and engineered stem cell microenvironments
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Jul 23 2009
DOI: 10.1002/wsbm.46
Abstract Full article on Wiley Online Library:   HTML | PDF
Transcriptional networks that regulate muscle stem cell function
Focus Article
WIREs Systems Biology and Medicine
Published Online: May 04 2009
DOI: 10.1002/wsbm.11
Abstract Full article on Wiley Online Library:   HTML | PDF
Establishing the stem cell state: insights from regulatory network analysis of blood stem cell development
Focus Article
WIREs Systems Biology and Medicine
Published Online: Feb 14 2012
DOI: 10.1002/wsbm.1163
Abstract Full article on Wiley Online Library:   HTML | PDF
Mesenchymal stem cell differentiation and roles in regenerative medicine
Focus Article
WIREs Systems Biology and Medicine
Published Online: May 04 2009
DOI: 10.1002/wsbm.26
Abstract Full article on Wiley Online Library:   HTML | PDF
Toward a complete in silico , multi‐layered embryonic stem cell regulatory network
Focus Article
WIREs Systems Biology and Medicine
Published Online: Mar 24 2010
DOI: 10.1002/wsbm.93
Abstract Full article on Wiley Online Library:   HTML | PDF
Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Mar 15 2011
DOI: 10.1002/wsbm.145
Abstract Full article on Wiley Online Library:   HTML | PDF
Sox2 and Oct‐3/4: a versatile pair of master regulators that orchestrate the self‐renewal and pluripotency of embryonic stem cells
Focus Article
WIREs Systems Biology and Medicine
Published Online: Apr 29 2009
DOI: 10.1002/wsbm.12
Abstract Full article on Wiley Online Library:   HTML | PDF
Deciphering the complexities of human diseases and disorders by coupling induced‐pluripotent stem cells and systems genetics
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Apr 10 2012
DOI: 10.1002/wsbm.1170
Abstract Full article on Wiley Online Library:   HTML | PDF
Regulatory gene network circuits underlying T cell development from multipotent progenitors
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Oct 04 2011
DOI: 10.1002/wsbm.162
Abstract Full article on Wiley Online Library:   HTML | PDF
Human cardiomyogenesis and the need for systems biology analysis
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Dec 31 2010
DOI: 10.1002/wsbm.141
Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling the architecture and dynamics of hematopoiesis
Focus Article
WIREs Systems Biology and Medicine
Published Online: Sep 18 2009
DOI: 10.1002/wsbm.56
Abstract Full article on Wiley Online Library:   HTML | PDF
Engineered tissue grafts: opportunities and challenges in regenerative medicine
Focus Article
WIREs Systems Biology and Medicine
Published Online: Oct 19 2011
DOI: 10.1002/wsbm.164
Abstract Full article on Wiley Online Library:   HTML | PDF
Gut stem cells in tissue renewal and disease: methods, markers, and myths
Focus Article
WIREs Systems Biology and Medicine
Published Online: May 29 2012
DOI: 10.1002/wsbm.1176
Abstract Full article on Wiley Online Library:   HTML | PDF

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In the Spotlight

Philip Benfey

Philip Benfey

Is intrigued by one of the key questions in developmental biology: how cells acquire their identities. This is an important question in human development, where stem cells divide and differentiate into skin, muscle, fat etc. It is equally central to plant development, where most organs and cells are formed from stem cell populations known as meristems. The Benfey lab addresses this question using a combination of genetics, molecular biology, and genomics to identify and characterize the genes that regulate formation of the root in the plant model system, Arabidopsis thaliana. The choice of the root as a model was based on the simplicity of its organization and its stereotyped developmental program.

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