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WIREs Syst Biol Med
Impact Factor: 3.676

Stem Cells: A Systems Approach

This collection brings together a series of recent reviews that highlight many important aspects regarding systems analyses of stem cells.

Stem cell genome‐to‐systems biology
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Apr 11 2011
DOI: 10.1002/wsbm.151
Abstract Full article on Wiley Online Library:   HTML | PDF
Stem cell bioengineering at the interface of systems‐based models and high‐throughput platforms
Overview
WIREs Systems Biology and Medicine
Published Online: Aug 23 2012
DOI: 10.1002/wsbm.1189
Abstract Full article on Wiley Online Library:   HTML | PDF
The molecular circuitry underlying pluripotency in embryonic stem cells
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Jul 03 2012
DOI: 10.1002/wsbm.1182
Abstract Full article on Wiley Online Library:   HTML | PDF
Neural stem and progenitor cells in health and disease
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Sep 20 2013
DOI: 10.1002/wsbm.1239
Abstract Full article on Wiley Online Library:   HTML | PDF
Axes of differentiation in breast cancer: untangling stemness, lineage identity, and the epithelial to mesenchymal transition
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Nov 08 2013
DOI: 10.1002/wsbm.1252
Abstract Full article on Wiley Online Library:   HTML | PDF
Vascular tissue engineering: from in vitro to in situ
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Oct 22 2013
DOI: 10.1002/wsbm.1246
Abstract Full article on Wiley Online Library:   HTML | PDF
Establishing the stem cell state: insights from regulatory network analysis of blood stem cell development
Focus Article
WIREs Systems Biology and Medicine
Published Online: Feb 14 2012
DOI: 10.1002/wsbm.1163
Abstract Full article on Wiley Online Library:   HTML | PDF
Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Mar 15 2011
DOI: 10.1002/wsbm.145
Abstract Full article on Wiley Online Library:   HTML | PDF
Deciphering the complexities of human diseases and disorders by coupling induced‐pluripotent stem cells and systems genetics
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Apr 10 2012
DOI: 10.1002/wsbm.1170
Abstract Full article on Wiley Online Library:   HTML | PDF
Regulatory gene network circuits underlying T cell development from multipotent progenitors
Advanced Review
WIREs Systems Biology and Medicine
Published Online: Oct 04 2011
DOI: 10.1002/wsbm.162
Abstract Full article on Wiley Online Library:   HTML | PDF
Engineered tissue grafts: opportunities and challenges in regenerative medicine
Focus Article
WIREs Systems Biology and Medicine
Published Online: Oct 19 2011
DOI: 10.1002/wsbm.164
Abstract Full article on Wiley Online Library:   HTML | PDF
Gut stem cells in tissue renewal and disease: methods, markers, and myths
Focus Article
WIREs Systems Biology and Medicine
Published Online: May 29 2012
DOI: 10.1002/wsbm.1176
Abstract Full article on Wiley Online Library:   HTML | PDF

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In the Spotlight

William J. Pavan

William J. Pavan

is interested in using genomic tools to understand how an embryo develops into a functioning organism. His group focuses on neural crest cells, a group of stem cells that differentiate into a wide variety of tissues in the bodys. Issues with the development of the neural crest cells can cause many diseases, ranging from Waardenburg syndrome to cleft lip and palate. Using genomic research tools, Dr. Pavan seeks to identify the genes necessary for normal neural crest cell development, specifically the ones which differentiate into melanocytes. At least 15 genes have been recognized as important in the development of neural crest cells, but there are likely hundreds of genes involved in total. Dr. Pavan’s lab often uses the models of neural crest cell disorders in mice in order to identify the genes needed for normal development. They then study how these genes function, and whether there are corresponding genes in humans that can cause human diseases.

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