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WIREs Dev Biol
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Wiley Interdisciplinary Reviews:
WIREs Developmental Biology
Volume 9 Issue 3 (May 2020)
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Advanced Reviews

Developmental dynamics of neurogenesis and gliogenesis in the postnatal mammalian brain in health and disease: Historical and future perspectives
Published Online: Dec 11 2019
DOI: 10.1002/wdev.369
Continuous production of new neurons and glia in embryos and adults.
Abstract Full article on Wiley Online Library:   HTML | PDF
Hippo‐Yap/Taz signaling: Complex network interactions and impact in epithelial cell behavior
Published Online: Dec 11 2019
DOI: 10.1002/wdev.371
Hippo‐Yap/Taz integrate signals from multiple sources to modulate cell behavior. Cell–cell junctions, apical‐basal polarity, and nutrient sensing pathways induce Yap/Taz cytoplasmic sequestration for cell quiescence or differentiation. Growth factor signaling, integrin signaling, and metabolic pathways induce nuclear Yap/Taz and transcriptional activity to foster cell proliferation and stemness.
Abstract Full article on Wiley Online Library:   HTML | PDF
A critical look: Challenges in differentiating human pluripotent stem cells into desired cell types and organoids
Published Online: Nov 19 2019
DOI: 10.1002/wdev.368
A map of how human pluripotent stem cells differentiate into endodermal, mesodermal, and ectodermal cell‐types.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Article

Development of the brainstem respiratory circuit
Published Online: Dec 09 2019
DOI: 10.1002/wdev.366
The embryonic brainstem consists of many developmental domains defined by rostral‐caudal and dorsal‐ventral patterning genes. The two rhythmic respiratory nuclei, RTN/pF and preBötC, develop from independent domains characterized by the intersection of unique sets of genes.
Abstract Full article on Wiley Online Library:   HTML | PDF