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WIREs Dev Biol
Impact Factor: 4.185

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Wiley Interdisciplinary Reviews:
Developmental Biology
Volume 6 Issue 4 (July/August 2017)
Page 0 - 0

Cover Image

Cover Image, Volume 6, Issue 4
Published Online: Jun 23 2017
DOI: 10.1002/wdev.285
The cover image, by Hirotaka Tao et al., is based on the Advanced Review The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies, DOI: 10.1002/wdev.270.
Abstract Full article on Wiley Online Library:   HTML | PDF

Primers

Quantification of epithelial cell proliferation, cell dynamics, and cell kinetics in vivo
Published Online: May 05 2017
DOI: 10.1002/wdev.274
Two mitotic figures in the basal layer of the sheep rumen. The tissue was stained by the Feulgen reaction and the densely staining figures show the condensed chromosomes in an equatorial and an axial plane.
Abstract Full article on Wiley Online Library:   HTML | PDF
Potential mechanisms of Zika‐linked microcephaly
Published Online: Apr 06 2017
DOI: 10.1002/wdev.273
Zika virions likely bind phosphatidylserine receptors to enter fetal neural progenitor cells and impede normal brain growth.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Morphogen interpretation: concentration, time, competence, and signaling dynamics
Published Online: Mar 20 2017
DOI: 10.1002/wdev.271
During tissue patterning, the transcriptional response of cells to inductive signals relies on tissue‐intrinsic competence to induce specific target genes and the ability of cells to interpret dynamics in morphogen exposure and signaling through transcriptional networks.
Abstract Full article on Wiley Online Library:   HTML | PDF
The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies
Published Online: Mar 20 2017
DOI: 10.1002/wdev.270
Two early limb bud regulatory domains generate two halves of the limb skeleton.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Article

Proximity‐dependent labeling methods for proteomic profiling in living cells
Published Online: Apr 07 2017
DOI: 10.1002/wdev.272
Proximity labeling for proteomic profiling To achieve regional protein labeling, the enzymes are usually fused with a targeting signal peptide or a spatially‐restricted protein (SP). The enzymes can also be fused with any protein of interest for protein interactome studies. After performing proximity labeling in living cells, the cells are lysed and the biotinylated endogenous proteins are isolated using steptavidin beads. Small peptides of enriched proteins are generated by trypsin digestion and subsequently ionized for MS analysis. The mass‐to‐charge (m/z) ratio of each peptide is then used to identify peptide sequence usually through computational comparison against established databases.
Abstract Full article on Wiley Online Library:   HTML | PDF

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