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WIREs Dev Biol
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Wiley Interdisciplinary Reviews:
Developmental Biology
Volume 8 Issue 4 (July 2019)
Page 0 - 0

Advanced Reviews

Developmental origins and oncogenic pathways in malignant brain tumors
Published Online: Apr 03 2019
DOI: 10.1002/wdev.342
Developmental origins and oncogenic pathways in brain tumors.
Abstract Full article on Wiley Online Library:   HTML | PDF
Development of the hematopoietic system: Role of inflammatory factors
Published Online: Mar 27 2019
DOI: 10.1002/wdev.341
Inflammatory factors regulate emergence and development of hematopoietic stem cells (HSCs).
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Article

Defects in intervertebral disc and spine during development, degeneration, and pain: New research directions for disc regeneration and therapy
Published Online: Apr 11 2019
DOI: 10.1002/wdev.343
Degeneration of the disc is a major cause of lower back pain. In mice, the molecular profile of the disc changes with age including decline in expression of crucial developmental markers including sonic hedgehog (SHH), WNTS, and Brachyury (BRA) along with their downstream targets like extracellular matrix (ECM). These molecular changes accompany age‐associated degenerative changes in the disc cells (indicated by black arrows in 2‐year‐old mouse lumbar disc). AF, annulus fibrosus; EP, endplate; NP, nucleus pulposus.
Abstract Full article on Wiley Online Library:   HTML | PDF