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WIREs Dev Biol
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Wiley Interdisciplinary Reviews:
Developmental Biology
Volume 7 Issue 4 (July/August 2018)
Page 0 - 0

Cover Image

Cover Image, Volume 7, Issue 4
Published Online: Jun 14 2018
DOI: 10.1002/wdev.326
The cover image, by Claire S. Simon et al., is based on the Advanced Review Making lineage decisions with biological noise: Lessons from the early mouse embryo, DOI: 10.1002/wdev.319.
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Advanced Reviews

Making lineage decisions with biological noise: Lessons from the early mouse embryo
Published Online: Apr 30 2018
DOI: 10.1002/wdev.319
Abstract Full article on Wiley Online Library:   HTML | PDF
Blueprint for an intestinal villus: Species‐specific assembly required
Published Online: Mar 07 2018
DOI: 10.1002/wdev.317
Prior to villus morphogenesis, the chick and mouse intestines both begin as a flat epithelial tube (blue) composed of thick pseudostratified endodermally derived cells surrounded by loose mesenchyme (light pink). By E6 in the chick, these thick epithelial cells shorten, taking on a more columnar shape and, with the confinement by organization of the outer circumferential muscle layer (red) at E8, they begin bending to create ridges that run length‐wise. With the addition of longitudinal muscle at E13, the ridges are transformed into zigzags, and finally by E16, a third layer of longitudinal muscle in direct apposition to the epithelium provides a final compressive force driving emergence of villi from the zigzags. In the mouse, villus emergence is not coordinate with sequential muscle layer development. Instead, villus emergence is initiated when aggregations of mesenchymal cells (clusters, dark pink) form adjacent to the thick pseudostratified epithelium under the direction of epithelial signals (purple). These clusters are highly patterned and together with forces within the epithelium between the clusters driven by cell division at the luminal side that extend the apical surface (T‐invaginations), villi are separated. Signals from the cluster instruct abutting epithelium to withdraw from the cell cycle and shorten, taking on a columnar shape. Epithelial cells between the clusters remain pseudostratified and highly proliferative, thus creating the intervillus domains.
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Embryonic neurogenesis in echinoderms
Published Online: Feb 22 2018
DOI: 10.1002/wdev.316
Nervous systems of the larvae of sea stars (left) and sea urchins (right) are proving to be useful models of embryonic neurogenesis that reveal fundamental similarities of deuterostome nervous systems.
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Focus Article

Uncovering cell type‐specific complexities of gene expression and RNA metabolism by TU‐tagging and EC‐tagging
Published Online: Jan 25 2018
DOI: 10.1002/wdev.315
TU‐tagging and EC‐tagging allow cell type‐specific RNA purification via targeted incorporation of modified nucleotides (orange circles) into nascent RNAs. Tagged RNAs are subsequently purified from a mixture of all RNAs..
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