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WIREs Dev Biol
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Wiley Interdisciplinary Reviews:
Developmental Biology
Volume 6 Issue 5 (September/October 2017)
Page 0 - 0

Cover Image

Cover Image, Volume 6, Issue 5
Published Online: Aug 17 2017
DOI: 10.1002/wdev.292
The cover image, by Ryan J. Smith et al., is based on the Advanced Review Signaling and epigenetic mechanisms of intestinal stem cells and progenitors: insight into crypt homeostasis, plasticity, and niches, DOI: 10.1002/wdev.281. Image Credit: Wasi Rizvi and Abilasha Rao‐Bhatia.
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Overview

Extrinsic regulation of hematopoietic stem cells in development, homeostasis and diseases
Published Online: May 31 2017
DOI: 10.1002/wdev.279
The interaction between hematopoietic stem cells (HSCs) and their environment is critical for the hematopoietic system in development, homeostasis, and diseases.
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Advanced Reviews

Signaling and epigenetic mechanisms of intestinal stem cells and progenitors: insight into crypt homeostasis, plasticity, and niches
Published Online: Jun 23 2017
DOI: 10.1002/wdev.281
Epigenetic, signaling, and niche factors influence intestinal cell homeostasis and plasticity.
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Mouth development
Published Online: May 17 2017
DOI: 10.1002/wdev.275
The mouth is essential for eating and has ancient origins. Comprising ectodermal and endodermal lineages, the mouth forms by a multistep process, whose disruption contributes to facial anomalies.
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Focus Articles

Emerging roles of transit‐amplifying cells in tissue regeneration and cancer
Published Online: Jul 03 2017
DOI: 10.1002/wdev.282
Transit‐amplifying cells (TACs) account for the bulk of tissue production while stem cells are mostly dormant. Recent discoveries uncover unexpected roles of TACs in regulating stem cells and the niches, sustaining homeostasis, and oncogenesis. Therefore, TACs are centrally important for homeostasis and disease, not just a passive intermediate population.
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Methods for studying the metabolic basis of Drosophila development
Published Online: May 26 2017
DOI: 10.1002/wdev.280
Drosophila development progresses through four easily recognized life stages. Metabolism adapts to the energetic and biosynthetic demands of each developmental stage. Several methods are available for studying developmental metabolism in Drosophila.
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Phenotypic plasticity and remodeling in the stress‐induced Caenorhabditis elegans dauer
Published Online: May 24 2017
DOI: 10.1002/wdev.278
The dauer stage of C. elegans undergoes large‐scale remodeling in several tissue types and is a model of phenotypic plasticity.
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Electrophysiological analysis of synaptic transmission in Drosophila
Published Online: May 24 2017
DOI: 10.1002/wdev.277
Electrical recordings of synaptic responses from Drosophila neuromuscular and central nervous systems.
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