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WIREs Dev Biol
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Wiley Interdisciplinary Reviews:
Developmental Biology
Volume 7 Issue 1 (January/February 2018)
Page 0 - 0

Cover Image

Cover Image, Volume 7, Issue 1
Published Online: Dec 28 2017
DOI: 10.1002/wdev.311
The cover image, by Asako Shindo, is based on the Advanced Review Models of convergent extension during morphogenesis, DOI: 10.1002/wdev.311.
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Overview

Serotonin neuron development: shaping molecular and structural identities
Published Online: Oct 26 2017
DOI: 10.1002/wdev.301
Understanding the development of 5‐HT brainstem neurons implies the dissection of developmental mechanisms that operate to specify 5‐HT molecular identity via gene regulatory networks and mechanisms that specify its structural organization, namely its organization in different cell groups with specific anatomical and functional properties. Gene regulatory networks activate and maintain expression of 5‐HT pathway genes for life long function of 5‐HT neurotransmission. Some of the transcription factors in these networks also diversify 5‐HT neuron identities by activating expression of different categories of genes in subsets of 5‐HT neurons. For each 5‐HT neuron in the human brain there are roughly 200,000 non‐5‐HT neurons. 5‐HT neurons elaborate long distance highly arborized axonal architectures that allow the small number of 5‐HT neurons to modulate nearly all CNS circuitry.
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Advanced Reviews

Mimicry in butterflies: co‐option and a bag of magnificent developmental genetic tricks
Published Online: Sep 14 2017
DOI: 10.1002/wdev.291
Key developmental mechanisms such as co‐option, heterochrony, and genetic cascades govern the evolution of adaptive butterfly wing patterns.
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Models of convergent extension during morphogenesis
Published Online: Sep 14 2017
DOI: 10.1002/wdev.293
This review discusses two modes of convergent extension (CE), the crawling and the contraction modes, and summarizes cell movements elicited by cytoskeleton dynamics, the participation of cell adhesion molecules, and the involvement of upstream regulatory molecules for each mode. Notochord formation in Xenopus laevis embryos has been one of the pioneering model systems of CE, thus the findings from the studies of X. laevis are mainly focused to approach the biological question of collective cell movement.
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RNA on the brain: emerging layers of post‐transcriptional regulation in cerebral cortex development
Published Online: Aug 24 2017
DOI: 10.1002/wdev.290
Post‐transcriptional regulation controls progenitor proliferation, neuronal differentiation, and migration, impacting all stages of corticogenesis.
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Charting the genotype–phenotype map: lessons from the Drosophila melanogaster Genetic Reference Panel
Published Online: Aug 22 2017
DOI: 10.1002/wdev.289
The Drosophila Genetic Reference Panel enables genome‐wide analyses to identify molecular novel variants, genes and pathways affecting quantitative traits.
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Focus Articles

Hearing crosstalk: the molecular conversation orchestrating inner ear dorsoventral patterning
Published Online: Oct 11 2017
DOI: 10.1002/wdev.302
Summary of the known otocyst transcription factors regulated by crosstalk among three families of secreted proteins during dorsoventral (DV) patterning. DV patterning of the otocyst is orchestrated by crosstalk among three families of secreted proteins that regulate the expression of transcription factors in a temporospatial manner. BMP signaling, which is required for the development of the dorsal (vestibular) component of the inner ear, upregulates the expression of two transcription factors, Dlx5 and Hmx3, both of which are essential for vestibular development. WNT and BMP signaling partner to induce Dlx5 expression in the dorsolateral wall of the otocyst, whereas WNT signaling acts alone in the dorsomedial wall to regulate the expression of Gbx2, which in turn seems to be required for Dlx5 expression. SHH signaling, which is required for the development of the ventral (cochlear) component of the inner ear, upregulates the expression of two transcription factors, Pax2 and Otx2, both of which are essential for cochlear development. The expression of transcription factors in the dorsal and ventral otocyst also is inhibited by secreted factors, with BMP signaling downregulating Otx2 expression and SHH signaling downregulating Hmx3 expression and arguably downregulating Dlx5 expression.
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Regulation of germ cell development by intercellular signaling in the mammalian ovarian follicle
Published Online: Sep 11 2017
DOI: 10.1002/wdev.294
All stages of postnatal oocyte development depend on communication with the neighboring somatic granulosa cells of the ovarian follicle. Signals sent by the oocyte also regulate differentiation of the granulosa cells and ensure that they provide a healthy environment for the germ cell.
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