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WIREs Dev Biol
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Wiley Interdisciplinary Reviews:
Developmental Biology
Volume 7 Issue 2 (March 2018)
Page 0 - 0

Cover Image

Cover Image, Volume 7, Issue 2
Published Online: Feb 15 2018
DOI: 10.1002/wdev.318
The cover image, by Gabriel Gonzalez et al., is based on the Advanced Review Limbal stem cells: identity, developmental origin, and therapeutic potential, DOI: 10.1002/wdev.303.
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Overview

Formation of adult organs through metamorphosis in ascidians
Published Online: Nov 03 2017
DOI: 10.1002/wdev.304
The extensive reconstruction of tissues and organs from larval to adult ones during metamorphosis of Ciona. The tail is lost and the trunk grows to occupy the main part of the juvenile body. Mesodermal tissues are shown in green.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Cellular reprogramming: A new way to understand aging mechanisms
Published Online: Jan 19 2018
DOI: 10.1002/wdev.308
Cellular reprogramming allows scientists to model age‐related diseases, understand aging mechanisms and prevent aging.
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Scarless wound healing: Transitioning from fetal research to regenerative healing
Published Online: Jan 09 2018
DOI: 10.1002/wdev.309
The discovery of fetal scarless skin wound healing is an important breakthrough whose investigation drives many aspects of regenerative medicine and stem cell research. Several features of fetal scarless wound healing are well studied, but the exact mechanism to recapitulate scarless wound healing in adult skin remains elusive (Reprinted with permission from Leavitt et al. (2016). Copyright 2016 Springer).
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Dermal fibroblast in cutaneous development and healing
Published Online: Dec 15 2017
DOI: 10.1002/wdev.307
Schema of skin during embryonic development and in adult (left). After wounding, the adult skin heals by forming a scar which lacks hair follicles, glands, and other structures of the skin with the exception of scar‐free healing in the African spiny mouse (right).
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Generation of diverse cortical inhibitory interneurons
Published Online: Nov 08 2017
DOI: 10.1002/wdev.306
Inhibitory interneurons in the cerebral cortex constitute ~20–30% of the neuronal population. The rich array of interneuron subtypes endows local circuits with a remarkable computational power. How do the developmental origins (i.e. time and place of birth, progenitor behavior, lineage, etc.) influence the production and diversification of cortical interneurons?
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Limbal stem cells: identity, developmental origin, and therapeutic potential
Published Online: Nov 03 2017
DOI: 10.1002/wdev.303
Contribution of limbal stem cells to corneal epithelial development and homeostasis. Immunofluorescent image of corneal epithelium from a 1 month‐old Abcb5/Cre/tdTomato mouse depicting tdTomato‐positive Abcb5‐derived progeny cells within the entire adult mouse corneal epithelium. The white square on the left indicates the location of the limbus of which a high magnification image is shown on the right.
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Focus Article

Timing of neuronal plasticity in development and aging
Published Online: Nov 15 2017
DOI: 10.1002/wdev.305
Turn back the biological clock in old neurons.
Abstract Full article on Wiley Online Library:   HTML | PDF