William Garland, Torben Heick Jensen
Published Online: Nov 11 2019
DOI: 10.1002/wrna.1572
RNA Polymerase II produces a wide range of transcripts destined for multiple fates within the cell. Accurate processing and localization of RNAs are essential processes in maintaining a stable transcriptome. RNAs can be accurately processed and sorted in the nucleus through a number of pathways for either export to the cytoplasm, retention in subnuclear compartments or targeting to decay machineries.
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Michael Robert Murphy, Frida Esther Kleiman
Published Online: Oct 28 2019
DOI: 10.1002/wrna.1571
Categories of events and pathways involved at the intersection of mRNA 3′ end processing and DNA damage response.
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Charith Raj Adkar‐Purushothama, Jean‐Pierre Perreault
Published Online: Oct 22 2019
DOI: 10.1002/wrna.1570
Putative working model for the viroid derived small RNA induced production of secondary siRNA in viroid infected host plant.
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Erika Pereira Zambalde, Carolina Mathias, Ana Carolina Rodrigues, Enilze M. Souza Fonseca Ribeiro, Daniela Fiori Gradia, George A. Calin, Jaqueline Carvalho de Oliveira
Published Online: Sep 05 2019
DOI: 10.1002/wrna.1567
Transcribed ultraconserved regions (T‐UCRs) may be transcriptional regulated by specific transcription factors (TF) and DNA methylation (M), further, post‐transcriptional regulated by microRNAs (miRNAs). These expression regulations may be affected, and deregulated T‐UCRs have been associated with multifactorial diseases.
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Shama Prasada Kabekkodu, Vaibhav Shukla, Vinay Koshy Varghese, Divya Adiga, Padacherri Vethil Jishnu, Sanjiban Chakrabarty, Kapaettu Satyamoorthy
Published Online: Aug 22 2019
DOI: 10.1002/wrna.1563
Strategies for miRNA based therapy.
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Ofri Levi, Shahar Garin, Yoav Arava
Published Online: Aug 15 2019
DOI: 10.1002/wrna.1564
Aminoacyl tRNA synthetases (aaRSs) have a well‐established role in charging tRNA. Yet, aaRSs from various species have additional, non‐canonical roles in cellular functions. In this review we describe functions that affect mRNA functions post‐transcriptionally (noted in the sector with green background) and some non‐RNA functions (pink background).
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Yong Sun Lee, Nawapol Kunkeaw, Yeon‐Su Lee
Published Online: Jun 23 2019
DOI: 10.1002/wrna.1558
Apoptosis and inflammation: two opposite outcomes of PKR activation in cancer.
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