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Wiley Interdisciplinary Reviews:
RNA
Volume 9 Issue 6 (November/December 2018)
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Cover Image, Volume 9, Issue 6
Published Online: Oct 12 2018
DOI: 10.1002/wrna.1517
The cover image is based on the Advanced Review Dynamic RNA holo‐editosomes with subcomplex variants: Insights into the control of trypanosome editing by Jorge Cruz‐Reyes et al., DOI: 10.1002/wrna.1502.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Glycogen synthase kinase‐3 and alternative splicing
Published Online: Aug 17 2018
DOI: 10.1002/wrna.1501
Signaling pathways that regulate glycogen synthase kinase‐3 (GSK‐3) and splicing factor phosphorylation.
Abstract Full article on Wiley Online Library:   HTML | PDF
Regulation of cytoplasmic RNA stability: Lessons from Drosophila
Published Online: Aug 15 2018
DOI: 10.1002/wrna.1499
RNA degradation in Drosophila is regulated by a variety of RNA‐binding proteins which direct transcripts to the progressive degradation enzymes. The sensitivity of particular transcripts to degradation affects critical cellular processes such as proliferation and apoptosis.
Abstract Full article on Wiley Online Library:   HTML | PDF
Dynamic RNA holo‐editosomes with subcomplex variants: Insights into the control of trypanosome editing
Published Online: Aug 12 2018
DOI: 10.1002/wrna.1502
RNA Holo‐Editosome in Trypanosomes.
Abstract Full article on Wiley Online Library:   HTML | PDF
Unconventional RNA‐binding proteins step into the virus–host battlefront
Published Online: Aug 09 2018
DOI: 10.1002/wrna.1498
The compendium of RNA‐binding proteins related to virus infection reveals an unexplored world of unconventional virus–host interactions.
Abstract Full article on Wiley Online Library:   HTML | PDF
Antisense and yet sensitive: Copy number control of rolling circle‐replicating plasmids by small RNAs
Published Online: Aug 03 2018
DOI: 10.1002/wrna.1500
Three‐dimensional structural models of pMV158 copG‐repB mRNA intergenic region (cyan), RNAII (red), and their early and final complex.
Abstract Full article on Wiley Online Library:   HTML | PDF
Regulation of translation initiation factor eIF2B at the hub of the integrated stress response
Published Online: Jul 10 2018
DOI: 10.1002/wrna.1491
At the central hub of the integrated stress response, a regulatory mechanism inhibits the translation initiation factor eIF2B (a large decameric protein) by phosphorylating eIF2α at serine 51 to downregulate global protein synthesis and activate specific genes that act to restore homeostasis.
Abstract Full article on Wiley Online Library:   HTML | PDF
RNA methylation in nuclear pre‐mRNA processing
Published Online: Jun 19 2018
DOI: 10.1002/wrna.1489
Messenger RNA (mRNA) undergoes a number of processing steps in the nucleus before it is exported to the cytoplasm, where it serves as a template for protein synthesis. The N6‐methyladenosine (m6A) mark, and factors that write, read, and erase it, have been implicated in the regulation of mRNA processing.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Article

Ataxin‐2: A versatile posttranscriptional regulator and its implication in neural function
Published Online: Jun 05 2018
DOI: 10.1002/wrna.1488
Ataxin‐2 (ATXN2) is an evolutionarily conserved, RNA‐binding protein that has been implicated in neural physiology and neurodegenerative diseases. Emerging mechanisms that are key to the neural functions of ATXN2 include posttranscriptional control of gene expression, sequestration of cellular factors into cytoplasmic granules, and suppression of mTORC1 signaling.
Abstract Full article on Wiley Online Library:   HTML | PDF

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