Home
This Title All WIREs
WIREs RSS Feed
How to cite this WIREs title:
WIREs RNA
Impact Factor: 4.838

Current Issue

Wiley Interdisciplinary Reviews:
RNA
Volume 9 Issue 4 (July/August 2018)
Page 0 - 0

Cover Image

Cover Image, Volume 9, Issue 4
Published Online: Jun 14 2018
DOI: 10.1002/wrna.1490
The cover image, by Nikolay E. Shirokikh and Thomas Preiss, is based on the Overview Translation initiation by capdependent ribosome recruitment: Recent insights and open questions, DOI: 10.1002/wrna.1473. Image Credit: Dr. Cheryl Li, The Babraham Institute.
Abstract Full article on Wiley Online Library:   HTML | PDF

Overviews

Translation initiation by cap‐dependent ribosome recruitment: Recent insights and open questions
Published Online: Apr 06 2018
DOI: 10.1002/wrna.1473
Eukaryotic translation initiation involves small ribosomal subunit cap attachment, mRNA scanning, and start codon recognition, followed by large ribosomal subunit joining, and involves a remarkably extended set of initiation factors providing complex control of gene expression.
Abstract Full article on Wiley Online Library:   HTML | PDF
Genetic variants in mRNA untranslated regions
Published Online: Mar 26 2018
DOI: 10.1002/wrna.1474
Representation of human mature mRNA with indicated the main regulatory regions in the UTRs and the corresponding trans‐acting factors.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Targeting RNA in mammalian systems with small molecules
Published Online: May 03 2018
DOI: 10.1002/wrna.1477
Small molecules have been successfully used to study several mammalian RNA elements in disease. These advances encourage exploration of newly discovered RNA interactions with therapeutic potential.
Abstract Full article on Wiley Online Library:   HTML | PDF
Alternative‐splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics
Published Online: Apr 25 2018
DOI: 10.1002/wrna.1476
Splicing‐factor alterations in cancer
Abstract Full article on Wiley Online Library:   HTML | PDF
A 360° view of circular RNAs: From biogenesis to functions
Published Online: Apr 14 2018
DOI: 10.1002/wrna.1478
Besides generating a linear mRNA, many protein‐coding genes produce circular RNAs that are tightly regulated and have biological functions.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Article

Hfq chaperone brings speed dating to bacterial sRNA
Published Online: Apr 06 2018
DOI: 10.1002/wrna.1475
The chaperone Hfq accelerates match‐making between small regulatory RNA and mRNA in bacteria. The Hfq core (cyan) binds U and A rich RNA motifs, recruiting complementary strands to arginine patches (blue). Disordered C‐terminal domains (violet) sweep RNA from the core, quickly cycling prospective sRNA–mRNA pairs.
Abstract Full article on Wiley Online Library:   HTML | PDF

Access to this WIREs title is by subscription only.

Recommend to Your
Librarian Now!

The latest WIREs articles in your inbox

Sign Up for Article Alerts