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WIREs RNA
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Wiley Interdisciplinary Reviews:
WIREs RNA
Volume 11 Issue 3 (May 2020)
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From parts lists to functional significance—RNA–protein interactions in gene regulation
Cornelia Kilchert, Katja Sträßer, Vladislav Kunetsky, Minna‐Liisa Änkö
Published Online: Dec 28 2019
DOI: 10.1002/wrna.1582
RNA binding proteins facilitate each step of RNA biogenesis of both coding and non‐coding RNAs in cells. They also play roles beyond these processes by forming different types of sub‐cellular organelles through their interactions with RNA.
Abstract Full article on Wiley Online Library:   HTML | PDF
tRNA introns: Presence, processing, and purpose
Casey A. Schmidt, A. Gregory Matera
Published Online: Dec 28 2019
DOI: 10.1002/wrna.1583
Processing pathway for eukaryotic intron‐containing tRNA transcripts.
Abstract Full article on Wiley Online Library:   HTML | PDF
On the role of mRNA secondary structure in bacterial translation
Claude Chiaruttini, Maude Guillier
Published Online: Nov 24 2019
DOI: 10.1002/wrna.1579
Messenger RNA secondary structure influences translation in bacteria and plays a key role in the rapid adaptation of these organisms to their surroundings.
Abstract Full article on Wiley Online Library:   HTML | PDF
The cell stress response: extreme times call for post‐transcriptional measures
Mariavittoria Pizzinga, Robert F. Harvey, Gavin D. Garland, Ryan Mordue, Veronica Dezi, Manasa Ramakrishna, Aristeidis Sfakianos, Mie Monti, Thomas E. Mulroney, Tuija Poyry, Anne E. Willis
Published Online: Nov 21 2019
DOI: 10.1002/wrna.1578
During the stress response, a combination of post‐transcriptional regulation strategies promotes substantial gene expression reprogramming, which leads to either adaptation or cell death.
Abstract Full article on Wiley Online Library:   HTML | PDF
Epitranscriptomic marks: Emerging modulators of RNA virus gene expression
Rachel Netzband, Cara T. Pager
Published Online: Nov 06 2019
DOI: 10.1002/wrna.1576
RNA modifications and RNA viruses.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Articles

Understanding and targeting the disease‐related RNA binding protein human antigen R (HuR)
Christopher W. Schultz, Ranjan Preet, Teena Dhir, Dan A. Dixon, Jonathan R. Brody
Published Online: Jan 23 2020
DOI: 10.1002/wrna.1581
HuR, an RNA binding protein, is critical for many disease states and is particularly important for cancer survival and resistance to therapeutics. As shown, we highlight three current strategies being utilized to target HuR.
Abstract Full article on Wiley Online Library:   HTML | PDF
Computational methods for ribosome profiling data analysis
Stephen J. Kiniry, Audrey M. Michel, Pavel V. Baranov
Published Online: Nov 24 2019
DOI: 10.1002/wrna.1577
Ribosome profiling provides key insights into various aspects of the translatome, allowing for discovery of novel coding regions, pause sites and identification of differentially translated genes.
Abstract Full article on Wiley Online Library:   HTML | PDF
mRNA 3′ end formation in plants: Novel connections to growth, development and environmental responses
Arthur G. Hunt
Published Online: Nov 07 2019
DOI: 10.1002/wrna.1575
Illustration depicting hypothetical pathways through which signaling cues converge upon the plant polyadenylation complex. This illustration summarizes points discussed in the review, including different phenotypes associated with poly(A) factor mutants, specific poly(A) complex subunits that are discussed, poly(A)‐related consequences of mutations affecting various of these subunits, and possible connections with signaling‐related biochemical activities.
Abstract Full article on Wiley Online Library:   HTML | PDF

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