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WIREs RNA
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Current Issue

Wiley Interdisciplinary Reviews:
RNA
Volume 9 Issue 2 (March/April 2018)
Page 0 - 0

Cover Image

Cover Image, Volume 9, Issue 2
Published Online: Feb 16 2018
DOI: 10.1002/wrna.1472
The cover image, by Curtis A. Nutter and Muge N. Kuyumcu‐Martinez, is based on the Advanced Review Emerging roles of RNA‐binding proteins in diabetes and their therapeutic potential in diabetic complications, DOI: 10.1002/wrna.1459.
Abstract Full article on Wiley Online Library:   HTML | PDF

Overview

Molecular and genetic interactions of the RNA degradation machineries in Firmicute bacteria
Published Online: Jan 05 2018
DOI: 10.1002/wrna.1460
Schematic overview of the main interactions within the network of the RNA degradation machinery.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Natural antisense transcripts in diseases: From modes of action to targeted therapies
Published Online: Jan 17 2018
DOI: 10.1002/wrna.1461
Natural antisense transcripts (NATs) are potent regulators of gene expression and as such they are implicated in aethiology of a number of human diseases.
Abstract Full article on Wiley Online Library:   HTML | PDF
Noncoding RNAs in Alzheimer's disease
Published Online: Jan 12 2018
DOI: 10.1002/wrna.1463
Schematic of the three main domains of AD pathogenesis. Top, APP is cleaved by α, β, and γ secretases; the generation and aggregation of amyloidogenic Aβ peptides outside of the cell leads to the formation of amyloid plaques. Bottom, the hyperphosphorylation of Tau protein results in formation of intracellular neurofibrillary tangles. Right, amyloid plaques and neurofibrillary tangles create a toxic environment characterized by neuroinflammation and neurodegeneration. Key, top right
Abstract Full article on Wiley Online Library:   HTML | PDF
Emerging roles of RNA‐binding proteins in diabetes and their therapeutic potential in diabetic complications
Published Online: Dec 27 2017
DOI: 10.1002/wrna.1459
Role of RNA‐binding proteins in development of diabetes and diabetic complications.
Abstract Full article on Wiley Online Library:   HTML | PDF
Viral internal ribosomal entry sites: four classes for one goal
Published Online: Nov 29 2017
DOI: 10.1002/wrna.1458
Viral internal ribosomal entry sites.
Abstract Full article on Wiley Online Library:   HTML | PDF
The GAIT translational control system
Published Online: Nov 20 2017
DOI: 10.1002/wrna.1441
IFN‐γ‐stimulated activation of the GAIT complex in human myeloid cells. A network of phosphorylation events recruits EPRS and ribosomal protein L13a to join GAPDH and NSAP1 to form the functional, heterotetrameric GAIT complex that binds GAIT element‐bearing mRNAs for translation‐inhibition.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Articles

Cold‐inducible RNA binding protein in cancer and inflammation
Published Online: Jan 11 2018
DOI: 10.1002/wrna.1462
Summary of CIRP Roles in Inflammation and Cancer. CIRP shuttles from the nucleus to the cytoplasm to bind the 3' UTRs of target mRNA to increase their translation. It is possible that CIRP can bind tumor promoting cytokines in certain contexts. CIRP in found extracellularly in patients with sepsis (likely through lysosomal secretion) where it binds the TLR‐4 MD2 complex, functioning as a DAMP and stimulating cytokine release from APCs. Also, CIRP increases I phosphorylation through an unknown mechanism. Arrows and boxes in black represent known roles from literature and red dashed arrows and boxes represent possible mechanisms or connections.
Abstract Full article on Wiley Online Library:   HTML | PDF
New perspectives on telomerase RNA structure and function
Published Online: Nov 09 2017
DOI: 10.1002/wrna.1456
Cross‐species conservation of telomerase RNA structure and function.
Abstract Full article on Wiley Online Library:   HTML | PDF

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