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WIREs RNA
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Wiley Interdisciplinary Reviews:
RNA
Volume 10 Issue 6 (November 2019)
Page 0 - 0

Cover Image

Cover Image
Published Online: Oct 11 2019
DOI: 10.1002/wrna.1569
The cover image is based on the Advanced Review MicroRNAs Meet with QTLs: Small Powerful Players in Regulating Quantitative Yield Traits in Rice, by Guiliang Tang, Quanzhi Zhao, Sachin Teotia, Ting Peng. https://doi.org/10.1002/wrna.1556
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Overview

RNA control in pain: Blame it on the messenger
Published Online: May 14 2019
DOI: 10.1002/wrna.1546
A key function of the peripheral nervous system is detection and amplification of pain promoting cues. Here we summarize multiple lines of evidence in support of the notion that mRNA localization, stability, and translation serve integral functions in pain signals originating from sensory neurons.
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Advanced Reviews

Pat1 RNA‐binding proteins: Multitasking shuttling proteins
Published Online: Jun 24 2019
DOI: 10.1002/wrna.1557
The conserved family of Pat1 nucleocytoplasmic shuttling RNA‐binding proteins mediate a wide range of RNA processing steps, including AU‐rich mRNA decay, translational repression and alternative splicing, depending on its associated heptameric Lsm complexes, and are found enriched in membrane‐less RNP granules including cytoplasmic P‐bodies and nuclear Cajal bodies.
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MicroRNAs meet with quantitative trait loci: Small powerful players in regulating quantitative yield traits in rice
Published Online: Jun 17 2019
DOI: 10.1002/wrna.1556
A summary of the miRNAs (highlighted in light blue) and their target genes (highlighted in purple) controlling rice yield‐related agronomic traits, including grain number, grain weight, tiller number, fertility, and leaf inclination. The miRNAs marked in red color are those controlling just one of the above mentioned five traits, based on the recent publications. The arrow and nail shape indicate positive and negative regulation, respectively.
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PIWI pathway against viruses in insects
Published Online: Jun 10 2019
DOI: 10.1002/wrna.1555
A detailed comparison between three insect models (Drosophila melanogaster, Bombyx mori, Aedes aegypti) is made in this review with regard to the response of PIWI pathway against viral infections.
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Nonsense‐mediated mRNA decay: The challenge of telling right from wrong in a complex transcriptome
Published Online: May 26 2019
DOI: 10.1002/wrna.1548
The nonsense‐mediated mRNA decay pathway, using the RNA helicase UPF1 as a focal point, collects many types of information about RNA‐protein complexes to select its targets.
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Recent methodology progress of deep learning for RNA–protein interaction prediction
Published Online: May 08 2019
DOI: 10.1002/wrna.1544
The history of machine learning‐based methods for predicting RNA‐protein interactions. Since the first deep learning‐based method DeepBind was developed, many deep models have been proposed for RNA‐protein interaction prediction.
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Focus Articles

mRNA methylation in cell senescence
Published Online: May 29 2019
DOI: 10.1002/wrna.1547
Main regulatory modifications reported in mRNAs encoding senescence‐associated proteins, m6A and m5C. Each modification can promote (green) or repress (purple) protein expression from the respective mRNAs.
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Molecular anatomy of the architectural NEAT1 noncoding RNA: The domains, interactors, and biogenesis pathway required to build phase‐separated nuclear paraspeckles
Published Online: May 01 2019
DOI: 10.1002/wrna.1545
The NEAT1 architectural RNA is a structural scaffold of membraneless paraspeckle nuclear bodies. NEAT1 possesses functional RNA domains that locally concentrate prion‐like proteins to induce liquid–liquid phase separation and form paraspeckles as gigantic RNP complexes.
Abstract Full article on Wiley Online Library:   HTML | PDF

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