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Wiley Interdisciplinary Reviews:
RNA
Volume 10 Issue 4 (July 2019)
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Cover Image, Volume 10, Issue 4
Published Online: Jun 14 2019
DOI: 10.1002/wrna.1559
The cover image is based on the Advanced Review Writing a Wrong: Coupled RNA Polymerase II Transcription and RNA Quality Control by Amber Mosley, Jose Victorino, Sarah Peck, and Katlyn Burriss. https://doi.org/10.1002/wrna.1529
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Extracellular RNA in viral–host interactions: Thinking outside the cell
Published Online: Apr 08 2019
DOI: 10.1002/wrna.1535
In normal physiology, host microRNAs (miRNAs) exported in extracellular vesicles (EVs) are involved in cell‐to‐cell communication and in maintaining homeostasis. Upon viral infection, the miRNA cargo of the EVs can be altered and enriched for specific (viral or host) miRNAs which influence immune responses in the recipient cell and alter the microenvironment.
Abstract Full article on Wiley Online Library:   HTML | PDF
miR‐146a‐5p: Expression, regulation, and functions in cancer
Published Online: Mar 20 2019
DOI: 10.1002/wrna.1533
miR‐146a acts as a tumor suppressor microRNA (miRNA) in some cancers and as an oncogenic miRNA in others. Studies suggest that this miRNA is tumor suppressive in non‐small cell lung cancer cells. Pictured here are the genetic and epigenetic events responsible for miR‐146a repression in this disease, along with the cellular consequences of decreased miR‐146a expression. Direct miR‐146a target genes become overexpressed, leading to increased cell proliferation, invasion, metastasis, and cell survival.
Abstract Full article on Wiley Online Library:   HTML | PDF
Splicing and neurodegeneration: Insights and mechanisms
Published Online: Mar 20 2019
DOI: 10.1002/wrna.1532
Splicing dysfunction contributes to neurodegeneration and is a viable therapeutic target.
Abstract Full article on Wiley Online Library:   HTML | PDF
The tandem zinc finger RNA binding domain of members of the tristetraprolin protein family
Published Online: Mar 12 2019
DOI: 10.1002/wrna.1531
Solution structure model showing a surface representation of the tandem zinc finger domain of human TTP. Zinc atoms are represented by green spheres, and the numbered RNA oligonucleotide by colored sticks. Shown underneath are the aligned domains from human (Hs) TTP, Drosophila (Dm) TIS11, and S. pombe (Sp) Zfs1.
Abstract Full article on Wiley Online Library:   HTML | PDF
Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control
Published Online: Mar 07 2019
DOI: 10.1002/wrna.1529
Dynamic coupling of RNAPII transcription complex and RNA processing machinery is the first‐line of defense for nuclear RNA quality control.
Abstract Full article on Wiley Online Library:   HTML | PDF
The cellular landscape of mid‐size noncoding RNA
Published Online: Mar 06 2019
DOI: 10.1002/wrna.1530
Mid‐size noncoding RNA structure and function.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Article

RNA regulation of the antiviral protein 2′‐5′‐oligoadenylate synthetase
Published Online: Apr 15 2019
DOI: 10.1002/wrna.1534
The 2′‐5′‐oligoadenylate synthetase/ribonuclease L (OAS/RNase L) pathway is a critical component of human innate immunity: double‐stranded RNA (dsRNA) binding to OAS drives activation of 2′‐5′‐oligoadenylate (2‐5A) synthesis to trigger the antiviral properties of RNase L.
Abstract Full article on Wiley Online Library:   HTML | PDF

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