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WIREs RNA
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Wiley Interdisciplinary Reviews:
RNA
Volume 8 Issue 4 (July/August 2017)
Page 0 - 0

Overview

Structures of RNA repeats associated with neurological diseases
Published Online: Jan 28 2017
DOI: 10.1002/wrna.1412
Crystallographic structures of RNA repeats associated with neurological disorders.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Box C/D small nucleolar RNA genes and the Prader‐Willi syndrome: a complex interplay
Published Online: Mar 13 2017
DOI: 10.1002/wrna.1417
The imprinted gene cluster at 15q11q13.
Abstract Full article on Wiley Online Library:   HTML | PDF
Microexons: discovery, regulation, and function
Published Online: Feb 11 2017
DOI: 10.1002/wrna.1418
A snapshot of microexon regulation and their ability to modulate protein properties, including mechanistic links to disease.
Abstract Full article on Wiley Online Library:   HTML | PDF
RNA in extracellular vesicles
Published Online: Jan 28 2017
DOI: 10.1002/wrna.1413
Extracellular vesicles (EVs) contain different RNA species, including messenger RNAs (mRNAs), microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and Circular RNAs (cirRNAs). These cargo RNAs may affect gene expression patterns in recipient cells and/or serve as diagnostic and prognostic markers.
Abstract Full article on Wiley Online Library:   HTML | PDF
mRNA localization as a rheostat to regulate subcellular gene expression
Published Online: Jan 24 2017
DOI: 10.1002/wrna.1416
Each localized mRNAs receives input from its subcellular locale and responds as a rheostat to output new proteins to meet local demands.
Abstract Full article on Wiley Online Library:   HTML | PDF
Regulation of mRNA following brain ischemia and reperfusion
Published Online: Jan 17 2017
DOI: 10.1002/wrna.1415
Dramatic image of CA3 neuron after 10‐min brain ischemia and 1‐h reperfusion shows redistribution of HuR (red) and polyadenylated mRNAs (green).
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Articles

Bioinformatic tools for analysis of CLIP ribonucleoprotein data
Published Online: Dec 23 2016
DOI: 10.1002/wrna.1404
Overview of CLIP‐Seq analysis, from the isolation of cellular RNPs to the identification and analysis of RBP‐bound RNA segments using the bioinformatic tools described in this review.
Abstract Full article on Wiley Online Library:   HTML | PDF
Regulation of mRNA turnover in cystic fibrosis lung disease
Published Online: Nov 13 2016
DOI: 10.1002/wrna.1408
Various trans‐factors (RNA‐binding proteins and/or miRNAs) interact with cis‐elements on the mRNA 3′‐UTR sequences and regulate the expression of F508del‐CFTR and proinflammatory chemokine and cytokine genes (like IL‐8 and IL‐6) in the cystic fibrosis airway. The concerted effect of these factors and the resulting complex regulatory network regulate the CF disease phenotype.
Abstract Full article on Wiley Online Library:   HTML | PDF

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