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WIREs RNA
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Wiley Interdisciplinary Reviews:
RNA
Volume 8 Issue 2 (March/April 2017)
Page 0 - 0

Overview

Extracellular RNA in aging
Published Online: Aug 17 2016
DOI: 10.1002/wrna.1385
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Perfect timing: splicing and transcription rates in living cells
Published Online: Nov 21 2016
DOI: 10.1002/wrna.1401
Schematic showing the progress of RNA polymerase II (Pol II) along the length of gene containing an intron (blue, top panel). The nascent RNA undergoes co‐transcriptional, capping splicing and polyadenylation cleavage. The association of spliceosomal components with the ends of the intron is represented by the presence of the red balls, and the exon‐exon junction is marked by a line. This review revisits a multitude of methods that measure in vivo splicing rates with respect to kilobasepair distance (ruler) from the 3' splice site (SS) or in units of time (clock, lower panel).
Abstract Full article on Wiley Online Library:   HTML | PDF
Developmental regulation of RNA processing by Rbfox proteins
Published Online: Oct 17 2016
DOI: 10.1002/wrna.1398
Rbfox binding sites associate with multiple RNA processing pathways. Nuclear binding sites influence pre‐mRNA processing and microRNA processing, activities that may be titrated by sequestration of Rbfox at SNORD116 binding sites. Cytoplasmic Rbfox binds 3'UTR sequences to influence mRNA stability and translation.
Abstract Full article on Wiley Online Library:   HTML | PDF
Advances in RNA molecular dynamics: a simulator's guide to RNA force fields
Published Online: Oct 04 2016
DOI: 10.1002/wrna.1396
Accurate simulation models for RNA require a delicate balancing of underlying driving forces.
Abstract Full article on Wiley Online Library:   HTML | PDF
Ligand‐dependent ribozymes
Published Online: Sep 30 2016
DOI: 10.1002/wrna.1395
Ligand‐dependent ribozymes are found in nature. They can also be generated artificially for constructing biosensors and synthetic genetic switches.
Abstract Full article on Wiley Online Library:   HTML | PDF
Neurodegeneration and RNA ‐binding proteins
Published Online: Sep 22 2016
DOI: 10.1002/wrna.1394
RNA‐binding proteins play an essential role in neuronal metabolism and when their expression is altered, this can lead to neurodegeneration and diseases.
Abstract Full article on Wiley Online Library:   HTML | PDF
AUF1 regulation of coding and noncoding RNA
Published Online: Sep 13 2016
DOI: 10.1002/wrna.1393
AUF1 enhances loading of select miRNAs into RISCs and can also regulate miRISC access to mRNA substrates.
Abstract Full article on Wiley Online Library:   HTML | PDF
Emerging roles and context of circular RNAs
Published Online: Sep 09 2016
DOI: 10.1002/wrna.1386
Abstract Full article on Wiley Online Library:   HTML | PDF
Roles of long noncoding RNAs in chromosome domains
Published Online: Aug 03 2016
DOI: 10.1002/wrna.1384
Abstract Full article on Wiley Online Library:   HTML | PDF
Modulating splicing with small molecular inhibitors of the spliceosome
Published Online: Jul 21 2016
DOI: 10.1002/wrna.1381
Small molecule inhibitors as tools to study the mechanics of the pre‐mRNA splicing by the spliceosome.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Article

Posttranscriptional regulation of intestinal epithelial integrity by noncoding RNAs
Published Online: Oct 04 2016
DOI: 10.1002/wrna.1399
Abstract Full article on Wiley Online Library:   HTML | PDF

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