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WIREs RNA
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Wiley Interdisciplinary Reviews:
WIREs RNA
Volume 11 Issue 1 (January 2020)
Page 0 - 0

Cover Image

Cover Image
Published Online: Dec 05 2019
DOI: 10.1002/wrna.1580
The cover image is based on the Review Article The Potential of Engineered Eukaryotic RNA‐Binding Proteins as Molecular Tools and Therapeutics, by Carl R. Shotwell, John Cleary, Andy Berglund. https://doi.org/10.1002/wrna.1573
Abstract Full article on Wiley Online Library:   HTML | PDF

Opinion

Fusion transcripts: Unexploited vulnerabilities in cancer?
Published Online: Aug 13 2019
DOI: 10.1002/wrna.1562
About one‐fifth of cancers harbor a fusion gene associated with disease pathology. The organization of fusion oncogenes can complicate the expression or structure of the mRNAs they express. The dependency of many cancer cells on the efficient biogenesis, and the continued presence of translatable fusion mRNAs offer potential RNA‐related therapeutic vulnerabilities.
Abstract Full article on Wiley Online Library:   HTML | PDF

Overview

The role of RNA G‐quadruplexes in human diseases and therapeutic strategies
Published Online: Sep 12 2019
DOI: 10.1002/wrna.1568
RNA G‐quadruplexes regulate cellular processes and are linked to various diseases.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

What is the switch for coupling transcription and splicing? RNA Polymerase II C‐terminal domain phosphorylation, phase separation and beyond
Published Online: Nov 03 2019
DOI: 10.1002/wrna.1574
Phosphorylation of Pol II CTD determines which droplet Pol II should join and that may function as a switch for coupling transcription and splicing.
Abstract Full article on Wiley Online Library:   HTML | PDF
The potential of engineered eukaryotic RNA‐binding proteins as molecular tools and therapeutics
Published Online: Nov 03 2019
DOI: 10.1002/wrna.1573
Combining RNA‐binding domain(s) that are not found naturally together and fusing functional domains to RBDs can lead to engineered proteins with novel functions.
Abstract Full article on Wiley Online Library:   HTML | PDF
Approaches for measuring the dynamics of RNA–protein interactions
Published Online: Aug 20 2019
DOI: 10.1002/wrna.1565
The network of RNA (red structures) and protein (circles) is determined by the dynamics of each interaction (grey lines).
Abstract Full article on Wiley Online Library:   HTML | PDF
Chemo‐enzymatic treatment of RNA to facilitate analyses
Published Online: Aug 08 2019
DOI: 10.1002/wrna.1561
Understanding how RNA molecules orchestrate gene expression pathways and malfunction in disease requires investigations of localization, interactions, and dynamics of RNA in living cells. In this review article, we highlight chemo‐enzymatic methods developed to make RNA accessible to analyses. In particular,chemo‐enzymatic strategies for RNA labeling, enrichment and detection of intrinsic modifications will be presented.
Abstract Full article on Wiley Online Library:   HTML | PDF
How to get away with nonsense: Mechanisms and consequences of escape from nonsense‐mediated RNA decay
Published Online: Jul 29 2019
DOI: 10.1002/wrna.1560
Variation in RNA quality control by NMD can lead to different gene expression outcomes of nonsense‐containing transcripts.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Article

Methods for analysis of circular RNAs
Published Online: Sep 05 2019
DOI: 10.1002/wrna.1566
Approaches and tools to study circular RNAs
Abstract Full article on Wiley Online Library:   HTML | PDF

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