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WIREs RNA
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Wiley Interdisciplinary Reviews:
RNA
Volume 9 Issue 3 (May/June 2018)
Page 0 - 0

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Cover Image, Volume 9, Issue 3
Published Online: Apr 20 2018
DOI: 10.1002/wrna.1483
The cover image, by Chang Ho Lee et al., is based on the Advanced Review Therapeutic applications of group I intron‐based trans‐splicing ribozymes DOI: 10.1002/wrna.1466.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Cytoplasmic functions of long noncoding RNAs
Published Online: Mar 08 2018
DOI: 10.1002/wrna.1471
Different levels of regulation of gene expression by cytoplasmic lncRNAs. Cytoplasmic lncRNAs can (clockwise from top): alter the stability and translation of mRNAs, activate signaling molecules, affect organelle function, modulate the stability of specific proteins, and serve as decoys for cytosolic factors.
Abstract Full article on Wiley Online Library:   HTML | PDF
Intron retention in viruses and cellular genes: Detention, border controls and passports
Published Online: Mar 06 2018
DOI: 10.1002/wrna.1470
The fate of detained and retained introns.
Abstract Full article on Wiley Online Library:   HTML | PDF
Mutually exclusive alternative splicing of pre‐mRNAs
Published Online: Feb 09 2018
DOI: 10.1002/wrna.1468
Recent progress range from the genome‐wide identification of mutually exclusive splicing events to the elucidation of underlying mechanism and function.
Abstract Full article on Wiley Online Library:   HTML | PDF
Circadian processes in the RNA life cycle
Published Online: Feb 09 2018
DOI: 10.1002/wrna.1467
All steps of the RNA life cycle are under the circadian clock control.
Abstract Full article on Wiley Online Library:   HTML | PDF
Therapeutic applications of group I intron‐based trans ‐splicing ribozymes
Published Online: Jan 31 2018
DOI: 10.1002/wrna.1466
Group I intron‐based trans‐splicing ribozyme specifically recognizes disease‐specific or associated RNA, removes the sequence downstream of the target site, and replaces it with a 3′‐exon encoding a therapeutic/reporter RNA sequence, inducing therapeutic/reporter activity selectively in the target RNA‐expressing cells.
Abstract Full article on Wiley Online Library:   HTML | PDF
Trans ‐acting translational regulatory RNA binding proteins
Published Online: Jan 17 2018
DOI: 10.1002/wrna.1465
Trans‐acting RNA binding proteins (RBPs) regulate mRNA translation by interacting with sequence elements in the 5′ and 3′ untranslated regions. These RBPs can control recruitment of the mRNAs to the ribosome and regulate the rate of protein synthesis or alternatively, repress mRNA translation through regulating mRNA instability/degradation.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Article

Complex HuR function in pancreatic cancer cells
Published Online: Feb 16 2018
DOI: 10.1002/wrna.1469
Role of HuR in pancreatic cancer progression.
Abstract Full article on Wiley Online Library:   HTML | PDF

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