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WIREs RNA
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Wiley Interdisciplinary Reviews:
RNA
Volume 10 Issue 2 (March 2019)
Page 0 - 0

Overview

Membraneless nuclear organelles and the search for phases within phases
Published Online: Oct 25 2018
DOI: 10.1002/wrna.1514
Membraneless organelles (MLOs) are a group of self‐assembling cellular structures that catalyze many processes, including RNA biogenesis. Their formation is initiated by various seeding RNAs, which recruit MLO‐specific intrinsically‐disordered proteins, followed by demixing from the surrounding nucleoplasm, and, ultimately, maturation into a core‐shell state.
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Advanced Reviews

The DDX5/Dbp2 subfamily of DEAD‐box RNA helicases
Published Online: Dec 02 2018
DOI: 10.1002/wrna.1519
The DDX5/Dbp2 subfamily of RNA helicases act on multiple RNA substrates in a variety of cellular contexts. Some of these functions are characterized only in select organisms thus far, while others are shared across budding yeast, flies, and humans.
Abstract Full article on Wiley Online Library:   HTML | PDF
The evolution of RNA structural probing methods: From gels to next‐generation sequencing
Published Online: Nov 28 2018
DOI: 10.1002/wrna.1518
RNA structural probing
Abstract Full article on Wiley Online Library:   HTML | PDF
Noncanonical features and modifications on the 5′‐end of bacterial sRNAs and mRNAs
Published Online: Oct 01 2018
DOI: 10.1002/wrna.1509
5′ end modifications of bacterial RNAs.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Articles

Translational control during poxvirus infection
Published Online: Oct 31 2018
DOI: 10.1002/wrna.1515
Translational control during poxvirus infection.
Abstract Full article on Wiley Online Library:   HTML | PDF
Noncanonical RNA‐capping: Discovery, mechanism, and physiological role debate
Published Online: Oct 23 2018
DOI: 10.1002/wrna.1512
Noncanonical capping of RNA by RNA polymerase (RNAP). Ability to cap RNA with cellular cofactors is universal between bacterial, eukaryotic and mitochondrial RNAPs. RNA polymerase uses cellular cofactor as initiating substrate for RNA synthesis. Then RNA chain grows during elongation, while cofactor remains attached and serves as cap. Nucleases of NUDIX or DXO family act as decapping enzymes for noncanonically capped RNAs.
Abstract Full article on Wiley Online Library:   HTML | PDF

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