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WIREs RNA
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Wiley Interdisciplinary Reviews:
RNA
Volume 8 Issue 6 (November/December 2017)
Page 0 - 0

Cover Image

Cover Image, Volume 8, Issue 6
Published Online: Oct 13 2017
DOI: 10.1002/wrna.1457
The cover image, by Rajat Roy et al., is based on Advanced Review Emerging roles of hnRNPA1 in modulating malignant transformation, DOI: 10.1002/wrna.1431.
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Opinion

Single cell transcriptomics of noncoding RNAs and their cell‐specificity
Published Online: Aug 01 2017
DOI: 10.1002/wrna.1433
Single cell transcriptome analysis reveals cell‐to‐cell variability in noncoding RNA expression
Abstract Full article on Wiley Online Library:   HTML | PDF

Overview

Chromatin‐associated noncoding RNAs in development and inheritance
Published Online: Aug 25 2017
DOI: 10.1002/wrna.1435
Different types of chromatin associated non‐coding RNAs are crucial for many organismal and cellular processes.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

A jack of all trades: the RNA ‐binding protein vigilin
Published Online: Oct 04 2017
DOI: 10.1002/wrna.1448
The vigilin family of proteins is involved in a variety of cellular processes via interaction with a multitude of protein partners and promiscuous binding of nucleic acids. Here we discuss 30 years of vigilin research.
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Regulation and function of CMTR1‐dependent mRNA cap methylation
Published Online: Oct 02 2017
DOI: 10.1002/wrna.1450
CMTR1 functional domains. NLS, nuclear localization signal; G‐patch, glycine rich domain; RFM, Rossman‐fold methyltransferase domain; GT‐like, guanylyltransferase‐like domain; WW, protein interaction domain; phos, amino acid 28–66 multiple phosphorylation sites (sites with more than five references in phosphosite plus).37,38
Abstract Full article on Wiley Online Library:   HTML | PDF
Urinary microRNAs for prostate cancer diagnosis, prognosis, and treatment response: are we there yet?
Published Online: Aug 16 2017
DOI: 10.1002/wrna.1438
Urinary miRNAs and their role in diagnosis, prognosis, and treatment response of prostate cancer.
Abstract Full article on Wiley Online Library:   HTML | PDF
Organization of the Flavivirus RNA replicase complex
Published Online: Aug 16 2017
DOI: 10.1002/wrna.1437
Association of Flavivirus NS3 helicase (blue) and NS5 polymerase (red) is essential for viral RNA genome replication.
Abstract Full article on Wiley Online Library:   HTML | PDF
RNA‐mediated signal perception in pathogenic bacteria
Published Online: Aug 09 2017
DOI: 10.1002/wrna.1429
RNA sensing in pathogenic bacteria.
Abstract Full article on Wiley Online Library:   HTML | PDF
Emerging roles of hnRNPA1 in modulating malignant transformation
Published Online: Aug 08 2017
DOI: 10.1002/wrna.1431
hnRNPA1 is involved in multiple biological processes within the cell nucleus and cytoplasm. Counter‐clockwise: hnRNPA1 regulates mRNA stability, the transcription of G‐quadruplex containing genes, the nuclear export and translational de‐repression of IRES‐containing mRNAs, mRNA splicing and telomere length maintenance.
Abstract Full article on Wiley Online Library:   HTML | PDF
The La and related RNA ‐binding proteins (LARPs): structures, functions, and evolving perspectives
Published Online: Aug 07 2017
DOI: 10.1002/wrna.1430
La and La‐related proteins (LARPs) share a La module RNA‐binding platform and serve a variety of fundamental functions. La and its homologs LARP7, p65, and p43 associate with RNA polymerase‐III‐derived small RNAs in the nucleus, whereas LARPs 1, 4, and 6 function with cytoplasmic mRNAs.
Abstract Full article on Wiley Online Library:   HTML | PDF
An emerging model organism Caenorhabditis elegans for alternative pre‐ mRNA processing in vivo
Published Online: Jul 13 2017
DOI: 10.1002/wrna.1428
Recent progress in fluorescence reporter system and deep sequencing technologies turn C. elegans an excellent multicellular model organism for elucidating pre‐mRNA processing regulation in vivo
Abstract Full article on Wiley Online Library:   HTML | PDF
Chimeric RNAs in cancer and normal physiology
Published Online: Jun 07 2017
DOI: 10.1002/wrna.1427
Chimeric RNAs can be generated not only by chromosomal rearrangements at DNA level, but also by intergenic splicing at RNA level. Nowadays, they are often identified through RNA‐Seq. Chimeric RNAs are demonstrated not only to be the elusive features of cancer cells but also present in normal physiology. They can have diverse functions. This review summarized the generating mechanisms of chimeric RNAs, discussed different models, described approaches to identify chimeric RNAs, highlighted their relevance in cancer and normal cells, and offered our insights on the topic and directions for the future research.
Abstract Full article on Wiley Online Library:   HTML | PDF

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