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WIREs RNA
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Wiley Interdisciplinary Reviews:
RNA
Volume 8 Issue 3 (May/June 2017)
Page 0 - 0

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Cover Image, Volume 8, Issue 3
Published Online: Apr 21 2017
DOI: 10.1002/wrna.1425
The cover image, by Lauren A.Woodward et al., is based on Advanced Review The exon junction complex: a lifelong guardian of mRNA fate, DOI: 10.1002/wrna.1411.
Abstract Full article on Wiley Online Library:   HTML | PDF

Overview

New evolutionary insights into the non‐enzymatic origin of RNA oligomers
Published Online: Oct 26 2016
DOI: 10.1002/wrna.1400
The formamide‐based funnel model we present in this work outlines a straightforward path from primordial molecules to catalytically active oligonucleotides.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

The exon junction complex: a lifelong guardian of mRNA fate
Published Online: Dec 23 2016
DOI: 10.1002/wrna.1411
Assembly, structure, and function of the Exon Junction Complex (EJC).
Abstract Full article on Wiley Online Library:   HTML | PDF
Long noncoding RNAs in the p53 network
Published Online: Dec 19 2016
DOI: 10.1002/wrna.1410
DNA damage is known to induce cell cycle arrest, apoptosis and senescence via protein‐coding genes that are direct targets of p53. In addition, noncoding RNAs such as miRNAs (e.g., miR‐34a) and lncRNAs (e.g., PANDA, Pint, LincRNA‐p21and LED) mediate these effects of p53 by regulating a subset of p53 targets that control cell cycle arrest, apoptosis and senescence.
Abstract Full article on Wiley Online Library:   HTML | PDF
Current progress on microRNAs ‐based therapeutics in neurodegenerative diseases
Published Online: Nov 24 2016
DOI: 10.1002/wrna.1409
Barriers to in vivo microRNAs delivery
Abstract Full article on Wiley Online Library:   HTML | PDF
Unwinding the twister ribozyme: from structure to mechanism
Published Online: Nov 14 2016
DOI: 10.1002/wrna.1402
Small self‐cleaving ribozymes perform the same internal transesterification reaction although possessing distinct folds and active sites. They can employ four strategies to catalyze phosphordiester cleavage indicated by colored arrows (left panel; for explanation see main text). Close‐up view of the env22 twister ribozyme active site (right panel; pdb: 4RGE). The to‐be‐cleaved dinucleotide unit is shown in yellow. Guanine (G48) and adenine (A6) together with Mg2+ are likely the key players for twister ribozyme catalysis.
Abstract Full article on Wiley Online Library:   HTML | PDF
How to understand atomistic molecular dynamics simulations of RNA and protein– RNA complexes?
Published Online: Nov 10 2016
DOI: 10.1002/wrna.1405
MD simulations allow to study structural dynamics, flexibility, hydration, ion‐binding, base substitutions and other properties based on available atomistic experimental structures of RNAs and protein‐RNA complexes.
Abstract Full article on Wiley Online Library:   HTML | PDF
Posttranscriptional coordination of splicing and miRNA biogenesis in plants
Published Online: Nov 09 2016
DOI: 10.1002/wrna.1403
The crosstalk between transcription, splicing, polyadenylation and miRNA biogenesis machineries in the regulation of plant miRNA level.
Abstract Full article on Wiley Online Library:   HTML | PDF

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