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WIREs RNA
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Wiley Interdisciplinary Reviews:
WIREs RNA
Volume 10 Issue 3 (May 2019)
Page 0 - 0

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Computational approaches for circular RNA analysis
Published Online: Feb 20 2019
DOI: 10.1002/wrna.1528
Circular RNAs (circRNAs) are a recent addition to the expanding universe of RNA species and originate through back‐splicing events from linear primary transcripts. Detection of circRNAs from sequencing data is a complex bioinformatics process that requires specialized software tools. Novel tools allow a broad range of in silico analyses, such as initial prediction, first functional insights, reconstruction of internal sequences or aid in validation experiments.
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On the edge of degradation: Autophagy regulation by RNA decay
Published Online: Dec 17 2018
DOI: 10.1002/wrna.1522
During nutrient‐rich conditions in yeast, Rim15 is inhibited by the major cellular nutrient sensors protein kinase A (PKA) and TORC1. TORC1 phosphorylates the decapping factor Dcp2. Dcp2, Dhh1 and Xrn1 negatively regulate autophagy.
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Stress‐induced mRNP granules: Form and function of processing bodies and stress granules
Published Online: Feb 21 2019
DOI: 10.1002/wrna.1524
Diverse macromolecular interactions lead to the phase separation of protein and RNA during stress. While the identities of many proteins and RNAs contained in these granules (tan spheres) have been elucidated recently, the function of this conserved compartmentalization of the cytoplasm during stress response is still an open question.
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Splicing and cancer: Challenges and opportunities
Published Online: Feb 17 2019
DOI: 10.1002/wrna.1527
Cancer cells have specific splicing patterns defined by spliceosomal proteins, cis‐regulatory elements, and availability of regulatory proteins. Cellular phenotype will be defined by this pattern, affecting cellular proliferation, growth, migration and death, ultimately leading or not to malignant transformation.
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Mimicry, deception and competition: The life of competing endogenous RNAs
Published Online: Feb 13 2019
DOI: 10.1002/wrna.1525
The different regulatory functions of ceRNAs.
Abstract Full article on Wiley Online Library:   HTML | PDF
RNAs in the spliceosome: Insight from cryoEM structures
Published Online: Feb 06 2019
DOI: 10.1002/wrna.1523
Recent cryoEM structures offer new insight into the structure and function of spliceosomal RNAs.
Abstract Full article on Wiley Online Library:   HTML | PDF
Structure and function of Rnt1p: An alternative to RNAi for targeted RNA degradation
Published Online: Dec 11 2018
DOI: 10.1002/wrna.1521
The functional cycle of Rnt1p consists of five consecutive steps for RNAi‐independent cleavage of stem‐loop RNAs with NGNN capping loops.
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Diverse roles of RNA‐binding proteins in cancer traits and their implications in gastrointestinal cancers
Published Online: Nov 26 2018
DOI: 10.1002/wrna.1520
Schematic representation of the functions of RNA‐binding proteins (RBPs) in gastrointestinal cancer cells. Deregulated expression and/or localization of RBPs affect the posttranscriptional events in cancer cells and impact cell physiology through activation of cancer‐stimulated pathways.
Abstract Full article on Wiley Online Library:   HTML | PDF

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