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WIREs RNA
Impact Factor: 4.928
Wiley Interdisciplinary Reviews:
RNA
Volume 9 Issue 5 (September 2018)
Page 0 - 0

Cover Image

Cover Image, Volume 9, Issue 5
Published Online: Aug 17 2018
DOI: 10.1002/wrna.1505
The cover image, by Daan C. Swarts and Martin Jinek, is based on the Advanced Review Cas9 versus Cas12a/Cpf1: Structure–function comparisons and implications for genome editing, DOI: 10.1002/wrna.1481. Design Credit: Daan C. Swarts.
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Advanced Reviews

High throughput sequencing revolution reveals conserved fundamentals of U‐indel editing
Published Online: Jun 11 2018
DOI: 10.1002/wrna.1487
The functions and mechanisms of U‐indel editing of mRNA in kinetoplastid mitochondria exhibit similarities and differences across species. High throughput sequencing efforts are the key to new inquiry, including exploration of the origins and evolution of this process.
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PolyA tracks, polybasic peptides, poly‐translational hurdles
Published Online: Jun 05 2018
DOI: 10.1002/wrna.1486
Complexity of cellular outcomes during translation of mRNAs with polyA track motifs.
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The evolution of posttranscriptional regulation
Published Online: May 31 2018
DOI: 10.1002/wrna.1485
"DNA makes RNA makes protein." After transcription, mRNAs undergo a series of “posttranscriptional” regulatory processes to be finally translated into functional proteins. Changes in these regulatory processes are important driving forces underlying the evolution of phenotypic differences across different species.Source: Chlamydomonas by DBCLS 統合TV, CC BY 4.0; Volvox by Frank Fox—http://www.mikro-foto.de, CC BY‐SA 3.0 de; Solitary bee (Osmia cornifrons) by Beatriz Moisset—CC BY‐SA 3.0; Honeybee by Waugsberg—CC BY‐SA 3.0.
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Cas9 versus Cas12a/Cpf1: Structure–function comparisons and implications for genome editing
Published Online: May 22 2018
DOI: 10.1002/wrna.1481
Swarts and Jinek describe how distinct structural features can determine the choice for Cas9 or Cas12a/Cpf1 for genome editing applications.
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Suppressor of clathrin deficiency (Scd6)—An emerging RGG‐motif translation repressor
Published Online: May 22 2018
DOI: 10.1002/wrna.1479
Scd6 is an evolutionarily conserved protein with three domains Lsm, FDF, and, RGG. Scd6 family proteins have been implicated in three main functions, translation repression of mRNAs, decapping, and ER organization/intracellular protein trafficking. Here, we list existing facets about this protein family and processes. It is involved in highlighting its significance in the cellular milieu.
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LARP1 on TOP of ribosome production
Published Online: May 02 2018
DOI: 10.1002/wrna.1480
Ribosome production is a considerable energy investment for the cell—rRNAs and ribosomal proteins (RPs) are among the most abundant classes of RNAs and proteins—and their production must, therefore, be synchronized temporally and stoichiometrically to ensure efficient ribosome assembly. Multicellular eukaryotes control RP production at the level of mRNA translation. La‐related protein 1 (LARP1) is a novel target of mammalian target of rapamycin complex 1 (mTORC1) and key repressor of RP mRNA translation. LARP1 binds the 7‐methylguanosine triphosphate (m7Gppp) cap and adjacent 5′terminal oligopyrimidine (5′TOP) motif of mRNAs encoding RPs, some translation factors and some RNA‐binding proteins. In doing so, LARP1 prevents binding of the eukaryotic initiation factor 4E (eIF4E) to the m7Gppp cap and blocks the assembly of the eIF4F complex and the subsequent recruitment of the 40S ribosomal subunit to RP mRNAs. mTORC1 controls TOP mRNA translation by regulating the phosphorylation and association of LARP1 with the m7Gppp cap and the characteristic adjacent 5′TOP motif of TOP mRNAs.
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Guanidine‐sensing riboswitches: How do they work and what do they regulate?
Published Online: Apr 26 2018
DOI: 10.1002/wrna.1482
The Guanidine Riboswitch Family. Regulatory modes, secondary structure, and tertiary structure models for guanidine‐I, II, and III.
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Focus Article

Tales around the clock: Poly(A) tails in circadian gene expression
Published Online: Jun 17 2018
DOI: 10.1002/wrna.1484
External cues affect co‐ and post‐transcriptional regulation reflecting on diurnal poly(A) status that regulate RNA stability.
Abstract Full article on Wiley Online Library:   HTML | PDF

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