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WIREs Syst Biol Med
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Wiley Interdisciplinary Reviews:
WIREs Systems Biology and Medicine
Volume 12 Issue 4 (July 2020)
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Cover Image, Volume 12, Issue 4
Published Online: Jun 11 2020
DOI: 10.1002/wsbm.1498
The cover image is based on the Advanced Review Glucose transporter 1 in rheumatoid arthritis and autoimmunity by Ekaterina Zezina et al., https://doi.org/10.1002/wsbm.1483.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Multiscale modeling of vertebrate limb development
Published Online: Mar 24 2020
DOI: 10.1002/wsbm.1485
Drawings (left) and simulations (right) of experimentally manipulated (ZPA graft; chicken) (top), and mutant (Shh‐/‐Gli3‐/‐; mouse) (bottom) embryonic limbs.
Abstract Full article on Wiley Online Library:   HTML | PDF
Modeling immune cell behavior across scales in cancer
Published Online: Mar 04 2020
DOI: 10.1002/wsbm.1484
A better understanding of immune cell response in tumors requires multiscale modeling of intracellular signaling, multicellular interactions, and spatial and whole‐body dynamics.
Abstract Full article on Wiley Online Library:   HTML | PDF
Calibration of ionic and cellular cardiac electrophysiology models
Published Online: Feb 21 2020
DOI: 10.1002/wsbm.1482
A schematic of a cardiac electrophysiology model, highlighting the components described by equations that need to be calibrated using experimental data.
Abstract Full article on Wiley Online Library:   HTML | PDF
Glucose transporter 1 in rheumatoid arthritis and autoimmunity
Published Online: Feb 21 2020
DOI: 10.1002/wsbm.1483
Increased glucose uptake via the glucose transporter 1 (GLUT1) is essential for immune cell activation and is upregulated in different autoimmune diseases, like rheumatoid arthritis. Interference with GLUT1 using either genetic deletion or small molecules seems promising in different autoimmune mouse models and highlights the therapeutic potential of immunometabolism.
Abstract Full article on Wiley Online Library:   HTML | PDF
Cholesterol interaction motifs in G protein‐coupled receptors: Slippery hot spots?
Published Online: Feb 07 2020
DOI: 10.1002/wsbm.1481
Cholesterol binding/interaction motifs in GPCRs.
Abstract Full article on Wiley Online Library:   HTML | PDF

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