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WIREs Syst Biol Med
Impact Factor: 2.385

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Wiley Interdisciplinary Reviews:
Systems Biology and Medicine
Volume 9 Issue 6 (November/December 2017)
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Cover Image, Volume 9, Issue 6
Published Online: Oct 12 2017
DOI: 10.1002/wsbm.1409
The cover image, by Kelly S. Burrowes et al., is based on Advanced Review Image‐based computational fluid dynamics in the lung: virtual reality or new clinical practice?, DOI: 10.1002/wsbm.1392.
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Advanced Reviews

Genome‐scale metabolic models applied to human health and disease
Published Online: Jun 23 2017
DOI: 10.1002/wsbm.1393
Genome‐scale metabolic models are important tools for systems biology. Current research in the field involves using ‐omics data to obtain disease‐specific, patient‐specific, and organ‐specific models, using kinetomics, different objective functions, and multiple types of constraints to simulate metabolic reaction fluxes, and using model integration, increased model resolution, and individual‐based models to predict effects of drugs with patient specificity.
Abstract Full article on Wiley Online Library:   HTML | PDF
Image‐based computational fluid dynamics in the lung: virtual reality or new clinical practice?
Published Online: Jun 13 2017
DOI: 10.1002/wsbm.1392
Image‐based computational fluid dynamics predicts air flow in the respiratory system providing more sensitive biomarkers of lung function.
Abstract Full article on Wiley Online Library:   HTML | PDF
The best models of metabolism
Published Online: May 19 2017
DOI: 10.1002/wsbm.1391
The review discusses the challenge of selecting the most appropriate mathematical representation for a metabolic process.
Abstract Full article on Wiley Online Library:   HTML | PDF

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Jens Nielsen

Jens Nielsen
is a Professor in the Department of Biology and Biological Engineering at Chalmers University of Technology in Göteborg, Sweden. His research focus is on systems biology of metabolism. The yeast Saccharomyces cerevisiae is the lab’s key organism for experimental research, but they also work with Aspergilli oryzae.

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