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WIREs Syst Biol Med
Impact Factor: 3.709

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Wiley Interdisciplinary Reviews:
Systems Biology and Medicine
Volume 11 Issue 2 (March 2019)
Page 0 - 0

Focus Articles

Mathematical modeling of circadian rhythms
Published Online: Oct 17 2018
DOI: 10.1002/wsbm.1439
Physiological levels of modeling (e.g., organism, cellular, molecular). Mathematical structures of modeling (e.g., dynamical, statistical).
Abstract Full article on Wiley Online Library:   HTML | PDF
Context‐dependent regulation of receptor tyrosine kinases: Insights from systems biology approaches
Published Online: Sep 26 2018
DOI: 10.1002/wsbm.1437
The cellular and microenvironmental context controls the complex receptor tyrosine kinase networks. This context includes: extracellular ligands and other stimuli; receptors and coreceptors; intracellular trafficking; and downstream signaling. Systems biology approaches, including computational models and experimental “omics” techniques, are essential to understanding the regulation of this complex contextual network.
Abstract Full article on Wiley Online Library:   HTML | PDF
Quantitative systems models illuminate arrhythmia mechanisms in heart failure: Role of the Na+‐Ca2+‐Ca2+/calmodulin‐dependent protein kinase II‐reactive oxygen species feedback
Published Online: Jul 17 2018
DOI: 10.1002/wsbm.1434
Structural and functional data integration via multiscale quantitative cardiac modeling illuminates arrhythmia mechanisms in HF by investigating how disease‐induced remodeling alters the coupling of electrophysiology, Ca2+ and Na+ handling, contractile function, and energetics.
Abstract Full article on Wiley Online Library:   HTML | PDF

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