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WIREs Syst Biol Med
Impact Factor: 3.709

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Wiley Interdisciplinary Reviews:
Systems Biology and Medicine
Volume 11 Issue 1 (January/February 2019)
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The mammalian mycobiome: A complex system in a dynamic relationship with the host
Published Online: Sep 25 2018
DOI: 10.1002/wsbm.1438
The consortium of symbiont fungi on mammalian mucosal surfaces, collectively known as the mycobiota, exerts substantial effects on human health. Perturbations to the mycobiota due to host or environmental factors can disrupt these complex and dynamic interactions and potentially contribute to disease.
Abstract Full article on Wiley Online Library:   HTML | PDF
Committing the primordial germ cell: An updated molecular perspective
Published Online: Sep 18 2018
DOI: 10.1002/wsbm.1436
Mammalian primordial germ cells are induced by common signaling pathways. Downstream transcriptional events governing specification, however, diverge between species.
Abstract Full article on Wiley Online Library:   HTML | PDF
The mechanistic basis for chromatin regulation by pioneer transcription factors
Published Online: Jun 27 2018
DOI: 10.1002/wsbm.1427
Steps of chromatin regulation by pioneer factors: binding, opening, and beyond.
Abstract Full article on Wiley Online Library:   HTML | PDF
Kinetic models of hematopoietic differentiation
Published Online: Apr 16 2018
DOI: 10.1002/wsbm.1424
An example of computational modeling workflow for hematopoietic cell specification where new regulations and perturbation reactions are predicted from chip‐seq data and from comparing the predictive model simulations to expression levels time series experimental data.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Article

Computational methods for analyzing and modeling genome structure and organization
Published Online: Jul 18 2018
DOI: 10.1002/wsbm.1435
The iterative process of experimentation, hypothesis generation, and confirmation of three‐dimensional genomic features, exemplified by the development of the loop‐extrusion model.
Abstract Full article on Wiley Online Library:   HTML | PDF

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