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WIREs Syst Biol Med
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Wiley Interdisciplinary Reviews:
WIREs Systems Biology and Medicine
Volume 12 Issue 2 (March 2020)
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Primer

Theory of cell fate
Published Online: Dec 12 2019
DOI: 10.1002/wsbm.1471
The cell as a dynamical system: combining theory and experiment to understand cell fates.
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Functional genomic approaches to elucidate the role of enhancers during development
Published Online: Dec 05 2019
DOI: 10.1002/wsbm.1467
The correct spatiotemporal regulation of genes by enhancers is critical for successful development from a single fertilized egg to a complex multicellular organism. Herein, we discuss current genome‐wide approaches to identify enhancers and to dissect enhancer function. Figure created with BioRender.
Abstract Full article on Wiley Online Library:   HTML | PDF
Structural neuroimaging of the altered brain stemming from pediatric and adolescent hearing loss—Scientific and clinical challenges
Published Online: Dec 04 2019
DOI: 10.1002/wsbm.1469
Prototype model of individualised longitudinal evaluation of progress with amplification for pediatric and adolescent hearing loss. Quantification is achieved via atlas‐based analysis of structural (top left) and functional (top middle) neuroimaging data followed by correlational and connectivity analysis (top right). Tables of metadata are derived from analyses as well as behavioral data are posted at baseline and followup(s). Also posted are z‐score plots of metadata over time indicating progress (or lack thereof). Prototype is modelled on Figure 6 of Faria et al. (https://doi.org/10.1016/j.neuroimage.2012.03.078).
Abstract Full article on Wiley Online Library:   HTML | PDF
Exploring cardiac form and function: A length‐scale computational biology approach
Published Online: Dec 02 2019
DOI: 10.1002/wsbm.1470
This review, written for an interdisciplinary audience, is an overview of how multi‐scale problems in the heart have been addressed using a systems biology approach.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Articles

Single‐cell analysis of CD8 T lymphocyte diversity during adaptive immunity
Published Online: Dec 26 2019
DOI: 10.1002/wsbm.1475
Integration of deep profiling single‐cell technologies and systems‐based analyses to better understand CD8 T cell fate diversification during adaptive immunity.
Abstract Full article on Wiley Online Library:   HTML | PDF
Network architecture and regulatory logic in neural crest development
Published Online: Nov 08 2019
DOI: 10.1002/wsbm.1468
Neural crest cell development can be represented by a gene regulatory network that drives their induction, specification, migration, and differentiation.
Abstract Full article on Wiley Online Library:   HTML | PDF

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