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WIREs Syst Biol Med
Impact Factor: 3.709

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Wiley Interdisciplinary Reviews:
Systems Biology and Medicine
Volume 11 Issue 3 (May 2019)
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Integrating molecular networks with genetic variant interpretation for precision medicine
Published Online: Dec 12 2018
DOI: 10.1002/wsbm.1443
Conceptual representation of genome interpretation using biological networks.
Abstract Full article on Wiley Online Library:   HTML | PDF
Systems biology of robustness and homeostatic mechanisms
Published Online: Oct 29 2018
DOI: 10.1002/wsbm.1440
Homeostatic mechanism stabilize phenotypes against genetic and environmental variation. This show stability of extracellular serotonin against genetic variation in tryptophan hydroxylase (TPH) and the serotonin reuptake transporter (SERT). Genetic polymorphisms (white circles) have a large effect at the functional level (enzyme activity) but little effect at the phenotypic level.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Article

Chromatin imaging and new technologies for imaging the nucleome
Published Online: Nov 19 2018
DOI: 10.1002/wsbm.1442
New developments in fluorescence superÔÇÉresolution microscopy and labeling strategies enable visualization of chromatin structure and dynamics on the nanoscale level and in live cells.
Abstract Full article on Wiley Online Library:   HTML | PDF

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